{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:01:20Z","timestamp":1785020480921,"version":"3.55.0"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To investigate the role of 3-hydroxybutyrate dehydrogenase 2 (BDH2) in regulating ferroptosis and its impact on the metastasis of lung adenocarcinoma (LUAD). Expression levels of BDH2 were modulated in LUAD cell lines (A549, PC9) using pcDNA-BDH2 plasmid transfection. Cell motility was assessed by Transwell assays, while ferroptosis-associated markers, including Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , malondialdehyde (MDA), lipid reactive oxygen species (ROS), ACSL4, and GPX4, were evaluated by biochemical assays, flow cytometry, and Western blotting. The involvement of the Nrf2\/HO-1 signaling axis was analyzed by Western blotting and RT-qPCR. Furthermore, a xenograft mouse model was established to confirm the effect of BDH2 on tumor progression and metastasis\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Overexpression of BDH2 significantly inhibited LUAD cell migration and invasion. BDH2 upregulation enhanced ferroptosis, effects that were reversed by the ferroptosis inhibitor Fer-1. Mechanistically, BDH2 suppressed the activation of the Nrf2\/HO-1 pathway, thereby enhancing sensitivity to ferroptosis.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , BDH2 overexpression markedly reduced tumor growth and metastasis in nude mice, while inhibition of ferroptosis attenuated these effects. BDH2 suppresses metastasis in LAUD by promoting ferroptosis via suppression of the Nrf2\/HO-1 pathway, highlighting BDH2 as a potential therapeutic target for LUAD.\n                  <\/jats:p>","DOI":"10.2478\/aite-2026-0012","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:17:14Z","timestamp":1775870234000},"source":"Crossref","is-referenced-by-count":0,"title":["BDH2 Inhibits Lung Adenocarcinoma Metastasis by Promoting Ferroptosis"],"prefix":"10.2478","volume":"74","author":[{"given":"Qiao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Oncology, Sinopharm Han Jiang Hospital , Shiyan City , Hubei Province , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Wuhan Wuchang Hospital , Wuhan , Hubei Province , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sinopharm Han Jiang Hospital , Shiyan City , Hubei Province , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sinopharm Han Jiang Hospital , Shiyan City , Hubei Province , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sinopharm Han Jiang Hospital , Shiyan City , Hubei Province , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Experimental Center, Sinopharm Dongfeng General Hospital , Hubei University of Medicine , Shiyan City , Hubei Province , , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"2026072522431173955_j_aite-2026-0012_ref_001","doi-asserted-by":"crossref","unstructured":"Cao JY, Dixon SJ (2016) Mechanisms of ferroptosis. 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