{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:44:17Z","timestamp":1777329857549,"version":"3.51.4"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of the study was to examine the genotype-allele determination of\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    rs2069514 and rs762551 polymorphisms in patients with mild and severe COVID-19 and to determine their effectiveness as prognostic criteria in COVID-19. The study consists of 60 patients who were hospitalized in intensive care or outpatient treatment due to COVID-19 in Istanbul NP Brain Hospital between 2020\u20132021. Genotyping was conducted by Real-Time PCR. Age (p&lt;0.001); chronic disease (p=0.002); cardiovascular disease (p=0.004); respiratory distress (p&lt;0.001); neurological disease (p=0.004); fatigue (p=0.048); loss of taste and smell (p=0.003); nausea\/vomiting (p=0.026); intubated (p&lt;0.001); ground glass image (p&lt;0.001) and\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    genotypes (p&lt;0.001) showed a statistically significant difference between patients with and without intensive care admission. According to multivariate logistic regression analysis,\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    *1A\/*1C + *1C\/*1C genotypes (OR:5.23 95% CI: 1.22\u201322.36; p=0.025), chronic disease (OR:4.68 95% CI:1.14\u201319.15; p=0.032) or patients at 65 years or older (OR:5.17, 95%CI:1.26\u201321.14; p=0.022) increased the risk of admission to the intensive care unit. According to our results, we strongly suggest considering the\n                    <jats:italic>CYP1A2<\/jats:italic>\n                    rs2069514 and rs762551 polymorphisms as important predictors of Intensive Care Unit admission in patients with COVID-19, and we also suggest that genotype results will guide clinicians for the benefit and the efficiency of the treatment.\n                  <\/jats:p>","DOI":"10.2478\/bjmg-2023-0005","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T05:54:22Z","timestamp":1691646862000},"page":"35-42","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Value of\n                    <i>CYP1A2<\/i>\n                    (rs2069514 and rs762551) Polymorphisms in COVID-19 Patients"],"prefix":"10.2478","volume":"26","author":[{"given":"I","family":"Bozkurt","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine , \u00dcsk\u00fcdar University , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"G\u00f6zler","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine , \u00dcsk\u00fcdar University , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Y\u00fcksel","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine , \u00dcsk\u00fcdar University , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ulucan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Molecular Diagnostic Laboratory, Faculty of Medicine , \u00dcsk\u00fcdar University , Istanbul , Turkey"},{"name":"Department of Medical Biology and Genetics, Faculty of Dentistry , Marmara University , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KN","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Uskudar University NP Hospital , Istanbul , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"2026042718400456139_j_bjmg-2023-0005_ref_001","doi-asserted-by":"crossref","unstructured":"Guan, W. 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