{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:03:42Z","timestamp":1794258222487,"version":"4.9.0"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alport syndrome is a hereditary disorder caused by a mutation in type IV collagen, leading to progressive kidney disease and eventual end- stage renal failure. Kidney transplantation represents the optimal therapeutic option, typically associated with excellent graft survival. We report a long-term outcome in two brothers with genetically confirmed Alport syndrome (\n                    <jats:italic>COL4A5<\/jats:italic>\n                    mutation inherited from their mother, also on hemodialysis). Receiving kidneys from the same deceased donor with only one HLA mismatch. A standard immunosuppression therapy was administered, including Anti-Thymocyte Globulin (ATG) as an induction, followed by maintenance therapy (steroids, a calcineurin inhibitor, and mycophenolic acid). Graft function in both recipients was established immediately, with diuresis up to 8 L and normalized serum creatinine within the first 24 hours after transplantation. During 12 years of follow-up, graft function remained stable, with normal serum creatinine levels, no occurrence of proteinuria, and no development of anti-HLA antibodies. The younger brother developed gingival hyperplasia and steroid-induced diabetes as complications of the therapy. Both patients remain employed and have families.\n                  <\/jats:p>","DOI":"10.2478\/bjmg-2026-0002","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:57:30Z","timestamp":1792004250000},"page":"77-80","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Kidney and Patient Survival after Deceased Donor Transplantation in Two Brothers with Alport Syndrome from the Same Donor"],"prefix":"10.2478","volume":"29","author":[{"given":"G","family":"Severova","sequence":"first","affiliation":[{"name":"University Clinic of Nephrology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Hamamdzieva","sequence":"additional","affiliation":[{"name":"University Clinic of Nephrology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Dzekova-Vidimliski","sequence":"additional","affiliation":[{"name":"University Clinic of Nephrology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Trajceska","sequence":"additional","affiliation":[{"name":"University Clinic of Nephrology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Rambabova-Bushljetik","sequence":"additional","affiliation":[{"name":"University Clinic of Nephrology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Gjorgjievski","sequence":"additional","affiliation":[{"name":"University Clinic of Nephrology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Trifunovski","sequence":"additional","affiliation":[{"name":"University Clinic of Urology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Ivanovski","sequence":"additional","affiliation":[{"name":"University Clinic of Urology , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Tasic","sequence":"additional","affiliation":[{"name":"University Pediatric Clinic , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"2026101418572477366_j_bjmg-2026-0002_ref_001","doi-asserted-by":"crossref","unstructured":"Torra R, Lipska-Zietkiewicz B, Acke F, et al. Diagnosis, management and treatment of the Alport syndrome \u2013 2024 guideline on behalf of ERKNet, ERA and ESPN. Nephrol Dial Transplant. 2025; 0:1\u201316. doi:10.1093\/ndt\/gfae265","DOI":"10.1093\/ndt\/gfae265"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_002","unstructured":"Kashtan CE. Alport Syndrome. In: GeneReviews\u00ae. Seattle (WA): University of Washington; updated 2024."},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_003","doi-asserted-by":"crossref","unstructured":"Kelly YP, Patil A, Wallis L, et al. Outcomes of kidney transplantation in Alport syndrome compared with other forms of renal disease. Ren Fail. 2017;39(1):290\u2013293.","DOI":"10.1080\/0886022X.2016.1262266"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_004","doi-asserted-by":"crossref","unstructured":"Soyeon K, Soon Huo Kwon. Renal Transplantation in Alport Syndrome. Kidney research and clinical practice.2025;44:583\u2013587","DOI":"10.23876\/j.krcp.24.143"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_005","doi-asserted-by":"crossref","unstructured":"Harshit P, Vivek K, Himianshu P, Engineer D. Outcome of renal transplantation in Alport Syndrome: a single center experience. Transplantation 2020; 194: S411","DOI":"10.1097\/01.tp.0000700692.33508.84"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_006","doi-asserted-by":"crossref","unstructured":"Andrew Mallett, Tang W, Clayton PA, et al. End-stage kidney disease due to Alport syndrome: outcomes in 296 consecutive ANZDATA registry cases. Nephrol Dial Transplant. 2014;29(12):2277\u20132286.","DOI":"10.1093\/ndt\/gfu254"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_007","doi-asserted-by":"crossref","unstructured":"Gillion V, Dahan K, Cosyns JP, et al. Genotype and outcome after kidney transplantation in Alport syndrome. Kidney Int Rep. 2018;3(3):652\u2013660.","DOI":"10.1016\/j.ekir.2018.01.008"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_008","doi-asserted-by":"crossref","unstructured":"Katharina Lange, Frederick Peters, Gerhard-Anton M\u00fcller et al. Outcomes of Male Patients with Alport Syndrome Undergoing Renal Replacement Therapy. Clin J Am Soc Nephrol 2012; 7: 1969\u20131976.","DOI":"10.2215\/CJN.02190312"},{"key":"2026101418572477366_j_bjmg-2026-0002_ref_009","doi-asserted-by":"crossref","unstructured":"Kaimori J, Ichimary N, Isaka Y, et al. Renal transplantation from parents to siblings with autosomal recessive Alport syndrome caused by a rearrangement in an intrinsic antisense Alu Element in the COL4A3 gene led to different outcomes. CEN Case Rep 9 2013); 2: 98\u2013101.","DOI":"10.1007\/s13730-012-0049-7"}],"container-title":["Balkan Journal of Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/bjmg-2026-0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:57:32Z","timestamp":1792004252000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/bjmg-2026-0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,10,14]]},"published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.2478\/bjmg-2026-0002"],"URL":"https:\/\/doi.org\/10.2478\/bjmg-2026-0002","relation":{},"ISSN":["2199-5761"],"issn-type":[{"value":"2199-5761","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]}}}