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We developed an isotope dilution gas chromatography-tandem mass spectrometry (ID-GC-MS\/MS) method for the detection of 2-nitropropane in mainstream cigarette smoke. The vapor fraction of mainstream cigarette smoke was collected in inert polyvinyl fluoride gas sampling bags and extracted with hexanes containing isotopically labeled internal standard, then purified and concentrated via solid-phase extraction using a normal phase silica adsorbent and a 100% dichloromethane eluant. This method is sensitive enough to measure vapor phase 2-nitro-propane concentrations in the nanogram range, with a 19 ng per cigarette method limit of detection. Product variability estimated from the analysis of 15 cigarette products yielded relative standard deviations ranging from 5.4% to 15.7%, and estimates of precision from two quality control products yielded relative standard deviations of 9.49% and 14.9%. Under the Health Canada Intense smoking regimen, 2-nitropropane in machine-generated mainstream smoke from 15 cigarette products ranged from 98.3 to 363 ng per cigarette.<\/jats:p>","DOI":"10.2478\/cttr-2019-0011","type":"journal-article","created":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T04:30:34Z","timestamp":1580617834000},"page":"300-309","source":"Crossref","is-referenced-by-count":1,"title":["Gas Chromatography-Tandem Mass Spectrometry Method for Selective Detection of 2-Nitropropane in Mainstream Cigarette Smoke"],"prefix":"10.2478","volume":"28","author":[{"given":"Gala M.","family":"Chapman","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention , 4770 Buford Highway NE, Atlanta , GA 30341 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Giraldo","family":"Junco","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , 4770 Buford Highway NE, Atlanta , GA 30341 , USA"},{"name":"Oak Ridge Institute for Science and Education , 1299 Bethel Valley Rd, Oak Ridge , TN 37830 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Bravo","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , 4770 Buford Highway NE, Atlanta , GA 30341 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford H.","family":"Watson","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , 4770 Buford Highway NE, Atlanta , GA 30341 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Valent\u00edn-Blasini","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention , 4770 Buford Highway NE, Atlanta , GA 30341 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,2,1]]},"reference":[{"key":"2026071213141207480_j_cttr-2019-0011_ref_001_w2aab3b7b2b1b6b1ab1ab1Aa","unstructured":"1. 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