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After defining how to evaluate emotions, we have reviewed the literature and summarized data of the PAG contribution to the feeling of emotions focusing on the behavioral and neurochemical considerations. In humans, emotions can be characterized by three main domains: the physiological changes, the communicative expressions, and the subjective experiences. In animals, the physiological changes can mainly be studied. Indeed, early studies have considered the PAG as an important center of the emotions-related autonomic and motoric processes. However, in vivo imaging have changed our view by highlighting the PAG as a significant player in emotions-related cognitive processes. The PAG lies on the crossroad of networks important in the regulation of emotions and therefore it should not be neglected. In vivo imaging represents a good tool for studying this structure in living organism and may reveal new information about its role beyond its importance in the neurovegetative regulation.<\/jats:p>","DOI":"10.2478\/enr-2018-0027","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T04:32:25Z","timestamp":1542861145000},"page":"222-238","source":"Crossref","is-referenced-by-count":16,"title":["Periaqueductal gray and emotions: the complexity of the problem and the light at the end of the tunnel, the magnetic resonance imaging"],"prefix":"10.2478","volume":"52","author":[{"given":"Dora","family":"Zelena","sequence":"first","affiliation":[{"name":"Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest , Hungary"},{"name":"Centre for Neuroscience, Szentagothai Research Centre, Institute of Physiology, Medical School, University of Pecs, Pecs , Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ophelie","family":"Menant","sequence":"additional","affiliation":[{"name":"INRA-CNRS-Universite de Tours-IFCE, UMR85, Physiologie de la Reproduction et des Comportements, Nouzilly , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Andersson","sequence":"additional","affiliation":[{"name":"Universite Fran\u00e7ois-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Chaillou","sequence":"additional","affiliation":[{"name":"INRA-CNRS-Universite de Tours-IFCE, UMR85, Physiologie de la Reproduction et des Comportements, Nouzilly , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,11,22]]},"reference":[{"key":"2026072604584824903_j_enr-2018-0027_ref_001_w2aab3b7b6b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"Abbadie C, Pan YX, Pasternak GW. 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