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The administration of pentoxifyl-line to diabetic animals led to an increase in the transcriptional activity of GLP-1R on the 4\n                    <jats:sup>th<\/jats:sup>\n                    week and decrease in transcriptional activity of DPP-4 on the 2\n                    <jats:sup>nd<\/jats:sup>\n                    and 4\n                    <jats:sup>th<\/jats:sup>\n                    weeks of the experiment. An increase in the normalized expression of SGLT-1 on the 4th week of the experimental diabetes was also noted, while the administration of pentoxifylline to diabetic animals did not lead to significant changes in this index. The transcriptional activity of the INSR and IGF-1R genes was reduced in diabetic rats and the administration of the non-specific TNF-\u03b1 blocker \u2013 pentoxifylline led to a significant increase only for INSR gene in animals on the 4\n                    <jats:sup>th<\/jats:sup>\n                    week of the experimental diabetes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions.<\/jats:bold>\n                    The expression of incretins, glucose transporters, and pro-inflammatory cytokines (e.g. TNF-\u03b1) in immune cells may be used as markers of several autoimmune pathologies progression such as type 1 diabetes due to their effect on the balance of pro- and anti-inflammatory factors.\n                  <\/jats:p>","DOI":"10.2478\/enr-2020-0019","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T10:46:18Z","timestamp":1598611578000},"page":"160-171","source":"Crossref","is-referenced-by-count":24,"title":["Changes in the transcriptional activity of the entero-insular axis genes in streptozotocin-induced diabetes and after the administration of TNF-\u03b1 non-selective blockers"],"prefix":"10.2478","volume":"54","author":[{"given":"Anna S.","family":"Degen","sequence":"first","affiliation":[{"name":"Zaporizhzhia State Medical University , Zaporizhzhia , Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna Y.","family":"Krynytska","sequence":"additional","affiliation":[{"name":"I. 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