{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:46:02Z","timestamp":1782812762827,"version":"3.54.5"},"reference-count":7,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective.<\/jats:bold>\n                    The aim of the study was to evaluate the influence of GHRL (rs696217) and LEPR (rs1137101) gene polymorphisms on weight loss dynamics and endocrine marker changes following various bariatric procedures.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and Methods.<\/jats:bold>\n                    A total of 76 patients undergoing laparoscopic sleeve gastrectomy (LSG), gastric plication (LGCP), and gastric artery embolization (GAE) were genotyped for GHRL (rs696217) and LEPR (rs1137101). Body mass index (BMI), total weight loss (TWL), excess weight loss (EWL), and hormonal markers (ghrelin, leptin, adiponectin, resistin, HbA1c) were assessed preoperatively and at 3, 6, and 12 months postoperatively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    Carriers of the T allele of GHRL (rs696217) experienced significantly greater reductions in BMI, TWL, and EWL, particularly following LSG and GAE (p&lt;0.05). A notable reduction in total ghrelin levels was observed in T allele carriers (up to \u201346.75%, p&lt;0.001) 6 months after surgery. Improvements in resistin (p=0.0002) and HbA1c (p=0.014) levels were also more pronounced in this group. LEPR (rs1137101) polymorphism showed limited impact on outcomes after LGCP, but it was associated with improved TWL and EWL in A allele carriers after LSG (p=0.006 and p=0.016, respectively).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion.<\/jats:bold>\n                    The T allele of GHRL (rs696217) appears to be a promising predictive marker for greater metabolic and hormonal improvement following bariatric procedures targeting the ghrelin-producing stomach zones. LEPR (rs1137101) may also influence postoperative outcomes in a procedure-specific manner. These findings support the potential role of genetic screening in optimizing patient selection and predicting surgical success.\n                  <\/jats:p>","DOI":"10.2478\/enr-2025-0019","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:00:14Z","timestamp":1762866014000},"page":"167-170","source":"Crossref","is-referenced-by-count":0,"title":["Impact of GHRL (RS696217) and LEPR (RS1137101) gene polymorphisms on hormonal and anthropometric outcomes after bariatric surgery"],"prefix":"10.2478","volume":"59","author":[{"given":"Andrii","family":"Prodan","sequence":"first","affiliation":[{"name":"Department of Surgery, Postgraduate Faculty , I. Horbachevsky Ternopil National Medical University , Ternopil , Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"2026063009134715698_j_enr-2025-0019_ref_001","doi-asserted-by":"crossref","unstructured":"Genchi VA, D\u2019Oria R, Palma G, Caccioppoli C, Cignarelli A, Natalicchio A, Laviola L, Giorgino F, Perrini S. Impaired leptin signalling in obesity: is leptin a new thermolipokine? Int J Mol Sci 22, 6445, 2021.","DOI":"10.3390\/ijms22126445"},{"key":"2026063009134715698_j_enr-2025-0019_ref_002","doi-asserted-by":"crossref","unstructured":"Hanna C, Comstock F, Chatrath S, Posner A, Butsch J, Blum K, Gold MS, Georger S, Mastrandrea LD, Quattrin T, Thanos PK. Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review. Front Public Health 13, 1516122, 2025.","DOI":"10.3389\/fpubh.2025.1516122"},{"key":"2026063009134715698_j_enr-2025-0019_ref_003","doi-asserted-by":"crossref","unstructured":"Sahin-Efe A, Polyzos SA, Dincer F, Zaichenko L, McGovern R, Schneider B, Mantzoros CS. Intracellular leptin signaling following effective weight loss. Metabolism 64, 888\u2013895, 2015.","DOI":"10.1016\/j.metabol.2015.04.006"},{"key":"2026063009134715698_j_enr-2025-0019_ref_004","doi-asserted-by":"crossref","unstructured":"Sarkar R. Patient selection in bariatric surgery. In obesity, bariatric and metabolic surgery: a comprehensive guide (pp. 121\u2013140). Cham: Springer International Publishing 2023.","DOI":"10.1007\/978-3-030-60596-4_8"},{"key":"2026063009134715698_j_enr-2025-0019_ref_005","doi-asserted-by":"crossref","unstructured":"Tabaeian SP, Mahmoudi T, Sabzikarian M, Rezamand G, Dabiri R, Nobakht H, Asadi A, Farahani H, Mansour- Ghanaei F, Zali MR. The Leu72Met (rs696217 G> T) polymorphism of the ghrelin gene might be a protective factor for nonalcoholic fatty liver disease. J Gastrointestin Liver Dis 30, 233\u2013239, 2021.","DOI":"10.15403\/jgld-2703"},{"key":"2026063009134715698_j_enr-2025-0019_ref_006","doi-asserted-by":"crossref","unstructured":"Thanos PK, Hanna C, Mihalkovic A, Hoffman AB, Posner AR, Busch J, Smith C, Badgaiyan RD, Blum K, Baron D, Mastrandrea LD, Quattrin T. The first exploratory personalized medicine approach to improve bariatric surgery outcomes utilizing psychosocial and genetic risk assessments: encouraging clinical research. J Pers Med 13, 1164, 2023.","DOI":"10.3390\/jpm13071164"},{"key":"2026063009134715698_j_enr-2025-0019_ref_007","doi-asserted-by":"crossref","unstructured":"Vitolo E, Santini E, Seghieri M, Giannini L, Coppede F, Rossi C, Dardano A, Solini A. Heterozygosity for the rs696217 SNP in the preproghrelin gene predicts weight loss after bariatric surgery in severely obese individuals. Obes Surg 27, 961\u2013967, 2017.","DOI":"10.1007\/s11695-016-2387-6"}],"container-title":["Endocrine Regulations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/enr-2025-0019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T09:21:45Z","timestamp":1782811305000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/enr-2025-0019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,1,1]]}},"alternative-id":["10.2478\/enr-2025-0019"],"URL":"https:\/\/doi.org\/10.2478\/enr-2025-0019","relation":{},"ISSN":["1336-0329"],"issn-type":[{"value":"1336-0329","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]}}}