{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:19:36Z","timestamp":1783354776123,"version":"3.54.6"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective.<\/jats:bold>\n                    Thyroid dysfunction is associated with metabolic disturbances and an increased risk of atherosclerosis. This cross-sectional study investigated the relationships between the triglyceride-glucose index (TyG index), complement C5, lipoprotein(a) (Lp(a)), and carotid intima-media thickness (cIMT).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods.<\/jats:bold>\n                    Clinical data were collected, blood samples analyzed, and cIMT measured using high-resolution ultrasound in 54 participants with thyroid dysfunction (27 with hypothyroidism and 27 with hyperthyroidism).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results.<\/jats:bold>\n                    The study found a significant positive correlation between the TyG index and cIMT in both hypothyroid and hyperthyroid patients. Complement C5 levels were also positively correlated with cIMT. No significant association was found between Lp(a) and cIMT.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion.<\/jats:bold>\n                    These findings highlight the complex interplay between thyroid dysfunction, metabolic dysregulation, and vascular health emphasizing the need for comprehensive cardiovascular risk assessment and management in patients with thyroid disorders.\n                  <\/jats:p>","DOI":"10.2478\/enr-2026-0001","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:06:10Z","timestamp":1774940770000},"page":"1-11","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of triglyceride-glucose index, complement C5, and lipoprotein(a) with carotid intima-media thickness in thyroid dysfunction: A cross-sectional study"],"prefix":"10.2478","volume":"60","author":[{"family":"Heri-Nugroho","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrine, and Metabolism, Department of Internal Medicine, Faculty of Medicine , Diponegoro University , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdopo","family":"Baskoro","sequence":"additional","affiliation":[{"name":"Department of Radiology , Dr. Kariadi Hospital , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Limantoro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Faculty of Medicine , Diponegoro University , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Arie","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Faculty of Medicine , Diponegoro University , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anugrah","family":"Riansari","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrine, and Metabolism, Department of Internal Medicine, Faculty of Medicine , Diponegoro University , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risa","family":"Ardiani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine , Diponegoro University , Semarang , Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"2026070615580888153_j_enr-2026-0001_ref_001","doi-asserted-by":"crossref","unstructured":"Becerra A, Bellido D, Luengo A, Piedrola G, De Luis DA. Lipoprotein(a) and other lipoproteins in hypothyroid patients before and after thyroid replacement therapy. Clin Nutr 18, 319\u2013322, 1999.","DOI":"10.1016\/S0261-5614(98)80031-9"},{"key":"2026070615580888153_j_enr-2026-0001_ref_002","doi-asserted-by":"crossref","unstructured":"Cheng H, Hu Y, Zhao H, Zhou G, Wang G, Ma C, Xu J. Exploring the association between triglyceride-glucose index and thyroid function. Eur J Med Res 28, 508, 2023.","DOI":"10.1186\/s40001-023-01501-z"},{"key":"2026070615580888153_j_enr-2026-0001_ref_003","doi-asserted-by":"crossref","unstructured":"Delitala AP, Fanciulli G, Maioli M, Delitala G. Subclinical hypothyroidism, lipid metabolism and cardiovascular disease. Eur J Intern Med 38, 17\u201324, 2017.","DOI":"10.1016\/j.ejim.2016.12.015"},{"key":"2026070615580888153_j_enr-2026-0001_ref_004","doi-asserted-by":"crossref","unstructured":"Ichiki T. Thyroid hormone and atherosclerosis. 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