{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T22:27:38Z","timestamp":1649197658773},"reference-count":0,"publisher":"Pensoft Publishers","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>A 34-year-old female smoker (4 packs a year), with the following symptoms: dry cough, moderate dyspnea, fatigue, night sweats and no exposure to respiratory poisoning or contact with tuberculosis. Clinical findings at admission: normal temperature, Hippocratic fingers and cyanosis, diminished bilateral breath sounds, fine bilateral rattling respiratory sounds, rhythmic cardiac noises, oxygen saturation 95%, pulse 87, blood pressure 125\/80 mm Hg. Chest computed tomography describes infiltration images of intra-alveolar and intra-bronchial with matte glass pattern, confluent and stretched across all lung segments. Pulmonary biopsy: preserved pulmonary architecture, thick alveolar septs and terminal bronchioles, alveoli and macrophages loaded with lipoprotein material. Bronchial aspirate: negative BAAR, no tumor cells. Bronchoalveolar lavage: opalescent, abundant PAS + appearance. total cell numbers \u2013 4.3 million, macrophages \u2013 34.1%, lymphocytes \u2013 56.9%, neutrophils \u2013 10%, eosinophils \u2013 0.4%, epithelial cells \u2013 33%.The treatment option chosen for this case was total bronchoalveolar lavage for therapeutic purposes. The patient had a rapid favourable evolution and at discharge was recommended a periodic imaging and functional control.<\/jats:p>\n<jats:p>Key Messages: Bronchoalveolar lavage is the optimal diagnostic method. Moderate\/severe forms, total bronchoalveolar lavage is recommended. Systemic corticotherapy or immunosuppression is not indicated. GM-CSF administered subcutaneously or by nebulization. Rituximab\/plasmapheresis are under evaluation. Pulmonary transplantation is indicated in patients who do not respond to therapeutic bronchoalveolar lavage repeated 6-12 months.<\/jats:p>","DOI":"10.2478\/folmed-2018-0048","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T15:28:07Z","timestamp":1561476487000},"page":"148-151","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Aspects and Evolution under Current Treatments on Pulmonary Alveolar Phospholipoproteinosis Patients"],"prefix":"10.3897","volume":"61","author":[{"given":"Petru-Emil","family":"Muntean","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2258","container-title":["Folia Medica"],"original-title":[],"link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/folmed\/61\/1\/article-p148.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T18:36:53Z","timestamp":1565807813000},"score":1,"resource":{"primary":{"URL":"http:\/\/content.sciendo.com\/view\/journals\/folmed\/61\/1\/article-p148.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2478\/folmed-2018-0048","relation":{},"ISSN":["1314-2143"],"issn-type":[{"value":"1314-2143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]}}}