{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:50:35Z","timestamp":1787071835302,"version":"build-2736575974"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Cystic echinococcosis (CE), an endemic zoonotic disease in Turkiye, is caused by the helminth\n                    <jats:italic>Echinococcus granulosus<\/jats:italic>\n                    . It has threatened the livestock industry and is of major medical and socio-economic importance to humans. Surgery is still the main practice of treatment, despite the risk of relapses and several adverse effects. Due to their minimal side effects, herbal products have been widely used for thousands of years to treat various infections. The present study was designed to investigate the\n                    <jats:italic>in vitro<\/jats:italic>\n                    protoscolicidal effect of extracts from\n                    <jats:italic>Hypericum perforatum, Thymus vulgaris, Pimenta racemosa<\/jats:italic>\n                    , and\n                    <jats:italic>Mentha piperita<\/jats:italic>\n                    against hydatid cyst protoscoleces. The livers and lungs of the sheep were obtained from a private abattoir, and the protoscoleces were collected under sterile conditions. The fi nal herbal products were extracted using the aqueous extraction method. Different concentrations of herbal extracts (50, 100, and 150 mg\/ml) were tested on\n                    <jats:italic>Echinococcus granulosus<\/jats:italic>\n                    protoscoleces, following different times of incubation (5, 10, and 60 min). The viability of the protoscoleces was assessed by a 0.1 % eosin staining method. Extracts of\n                    <jats:italic>H. perforatum, T. vulgaris<\/jats:italic>\n                    , and\n                    <jats:italic>P. racemosa<\/jats:italic>\n                    exhibited a statistically signifi cant effect on protoscoleces mortality (P&lt;0.001) when compared with the negative control. The present experimental study indicated that aqueous extracts of\n                    <jats:italic>H. perforatum, T. vulgaris<\/jats:italic>\n                    , and\n                    <jats:italic>P. racemosa<\/jats:italic>\n                    could be potential candidates as valuable and useful sources of protoscolicidal agents for CE.\n                  <\/jats:p>","DOI":"10.2478\/helm-2025-0021","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:03:32Z","timestamp":1759741412000},"page":"95-101","source":"Crossref","is-referenced-by-count":0,"title":["<i>In vitro<\/i>\n                    protoscolicidal effects of\n                    <i>Hypericum perforatum, Thymus vulgaris, Pimenta racemosa<\/i>\n                    , and\n                    <i>Mentha piperita<\/i>\n                    against\n                    <i>Echinococcus granulosus<\/i>\n                    protoscoleces"],"prefix":"10.2478","volume":"62","author":[{"given":"R.","family":"Yildiz","sequence":"first","affiliation":[{"name":"Division of Veterinary, Vocational School of Gevas, Van Yuzuncu Yil University , Van , Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Unlu","sequence":"additional","affiliation":[{"name":"Division of Veterinary, Vocational School of Gevas, Van Yuzuncu Yil University , Van , Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"2026081815590401701_j_helm-2025-0021_ref_001","doi-asserted-by":"crossref","unstructured":"Adas, G., Arikan, S., Kemik, O., Oner, A., Sahip, N., Karatepe, O. (2009): Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol, 15(1): 112. DOI: 10.3748\/wjg.15.112","DOI":"10.3748\/wjg.15.112"},{"key":"2026081815590401701_j_helm-2025-0021_ref_002","doi-asserted-by":"crossref","unstructured":"Al-Khlifeh, E., Saidat, N., Khleifat, K., Al Qaisi, Y. 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