{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T20:06:08Z","timestamp":1770926768032,"version":"3.50.1"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jccm-2019-0011_s_005_w2aab2b8c11b1b7b1aab1c16b1Aa\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patient-controlled analgesia with morphine is routinely used for postoperative pain management. Due to the safety profiles of the technique, which are patient\/disease related or technique\/equipment related, severe respiratory depression requiring opioid antagonists or airway management are uncommon.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jccm-2019-0011_s_006_w2aab2b8c11b1b7b1aab1c16b2Aa\">\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>The case of a patient with right colon carcinoma who was operated on for hemicolectomy under general anaesthesia and who presented with apnoea, after postoperatively receiving an initial bolus of 1mg of morphine. A large post-traumatic porencephalic cyst of the left brain hemisphere, previously undiagnosed, was found on the computed tomography scan. We excluded human errors, technique and equipment factors, and the patient did not have any other predisposing conditions like sleep apnoea, obesity, recent head injury or concurrent use of other sedatives. Previously the patient had been entirely asymptomatic, and her increased susceptibility to respiratory depression was the only clinical manifestation of porencephaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jccm-2019-0011_s_007_w2aab2b8c11b1b7b1aab1c16b3Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adult acquired porencephaly is seldom reported in the literature, clinical manifestations depending on the location and size of the cyst. In the present reported case, increased susceptibility to low-dose opioids might be associated with the structural and functional reorganisation of the brain after head trauma with the occurrence of the porencephalic cyst of the brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/jccm-2019-0011","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T05:31:45Z","timestamp":1557811905000},"page":"66-70","source":"Crossref","is-referenced-by-count":0,"title":["Increased Susceptibility to Postoperative PCA Morphine-Induced Respiratory Depression in a Patient with an Undiagnosed Traumatic Porencephalic Cyst \u2013 A Case Report"],"prefix":"10.2478","volume":"5","author":[{"given":"Cristina","family":"Petri\u0219or","sequence":"first","affiliation":[{"name":"Anesthesia and Intensive Care II Department, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Cluj-Napoca , Romania"},{"name":"Clinical Emergency County Hospital Cluj-Napoca , Cluj-Napoca , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Tranc\u0103","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care II Department, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Cluj-Napoca , Romania"},{"name":"Clinical Emergency County Hospital Cluj-Napoca , Cluj-Napoca , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea","family":"Cordo\u0219","sequence":"additional","affiliation":[{"name":"Clinical Emergency County Hospital Cluj-Napoca , Cluj-Napoca , Romania"},{"name":"Surgery Department I, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Cluj-Napoca , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasile","family":"Bin\u021bin\u021ban","sequence":"additional","affiliation":[{"name":"Clinical Emergency County Hospital Cluj-Napoca , Cluj-Napoca , Romania"},{"name":"Surgery Department I, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Cluj-Napoca , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,5,13]]},"reference":[{"key":"2026021219120770360_j_jccm-2019-0011_ref_001_w2aab2b8c11b1b7b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Grass JA. Patient-controlled analgesia. Anesth Analg. 2005;101(5S):S44-61.","DOI":"10.1213\/01.ANE.0000177102.11682.20"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_002_w2aab2b8c11b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Stone M, Wheatley B. Patient\u2010controlled analgesia. Br J Anaesth CEPD Reviews. 2002;2(3):79-82.","DOI":"10.1093\/bjacepd\/2.3.79"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_003_w2aab2b8c11b1b7b1ab2b1b3Aa","unstructured":"Yang DN, Townsend JC, Ilsen PF, Bright DC, Welton TH. Traumatic porencephalic cyst of the brain. Journal of the American Optometric Association. 1997;68(8):519-26."},{"key":"2026021219120770360_j_jccm-2019-0011_ref_004_w2aab2b8c11b1b7b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Douzenis A, Rizos EN, Papadopoulou A, Papathanasiou M, Lykouras L. Porencephaly and psychosis: a case report and review of the literature. BMC Psychiatry. 2010;10(1):19.","DOI":"10.1186\/1471-244X-10-19"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_005_w2aab2b8c11b1b7b1ab2b1b5Aa","doi-asserted-by":"crossref","unstructured":"Oommen AT, SeThy G, Minz NT, Patra J, Panda SS. Unusual presentation of porencephalic cyst in an adult. Journal of clinical and diagnostic research: J Clin Diagn Res. 2017;11(2): OD12.","DOI":"10.7860\/JCDR\/2017\/22654.9374"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_006_w2aab2b8c11b1b7b1ab2b1b6Aa","doi-asserted-by":"crossref","unstructured":"Nakao N, Oiwa Y, Moriwaki H. Unusual Posttraumatic Porencephaly. Neurol Med-Chir. 1991;31(3):169-72.","DOI":"10.2176\/nmc.31.169"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_007_w2aab2b8c11b1b7b1ab2b1b7Aa","doi-asserted-by":"crossref","unstructured":"Ryzenman JM, Rothholtz VS, Wiet RJ. Porencephalic cyst: a review of the literature and management of a rare cause of cerebrospinal fluid otorrhea. Otology and Neurotology. 2007;28(3):381-6.","DOI":"10.1097\/mao.0b013e31802ead9e"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_008_w2aab2b8c11b1b7b1ab2b1b8Aa","doi-asserted-by":"crossref","unstructured":"Resende M, Abrunhosa J, Gon\u00e7alves P, Dos Santos JG, Moreira F, Dos Santos AG. Traumatic porencephalic cyst and cholesteatoma of the ear. J Laryngol Otol. 2000;114(11):864-6.","DOI":"10.1258\/0022215001904185"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_009_w2aab2b8c11b1b7b1ab2b1b9Aa","doi-asserted-by":"crossref","unstructured":"de Oliveira-Souza R, Monteiro M, Pacheco P, et al. Right hemisphere dominance for language in a woman with schizophrenia and a porencephalic cyst of the left hemisphere. Neurocase. 2016;22(3):324-31.","DOI":"10.1080\/13554794.2016.1186199"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_010_w2aab2b8c11b1b7b1ab2b1c10Aa","doi-asserted-by":"crossref","unstructured":"Noyan OC, \u015eal\u00e7ini C, Talu BS, Eryilmaz G. Porencephalic cyst and late-onset brief psychotic disorder. Case Reports. 2016;bcr2016215098.","DOI":"10.1136\/bcr-2016-215098"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_011_w2aab2b8c11b1b7b1ab2b1c11Aa","doi-asserted-by":"crossref","unstructured":"Qureshi A, Jehangir A, York EP. Porencephalic cyst: a rare cause of new-onset seizure in an adult. J Community Hosp Intern Med Perspec. 2018;8(2):92-3.","DOI":"10.1080\/20009666.2018.1454788"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_012_w2aab2b8c11b1b7b1ab2b1c12Aa","doi-asserted-by":"crossref","unstructured":"Danckert J, Mirsattari SM, Danckert S, et al. Spared somatomotor and cognitive functions in a patient with a large porencephalic cyst revealed by fMRI. Neuropsychologia. 2004;42(3):405-18.","DOI":"10.1016\/j.neuropsychologia.2003.08.005"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_013_w2aab2b8c11b1b7b1ab2b1c13Aa","doi-asserted-by":"crossref","unstructured":"Brose WG, Cohen SE. Oxyhemoglobin saturation following cesarean section in patients receiving epidural morphine, PCA, or meperidine analgesia. Anesthesiology. 1989;70(6):948-53.","DOI":"10.1097\/00000542-198906000-00011"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_014_w2aab2b8c11b1b7b1ab2b1c14Aa","doi-asserted-by":"crossref","unstructured":"Baxter AD. Respiratory depression with patient-controlled analgesia. Can J Anaesth. 1994;41(2):87-90.","DOI":"10.1007\/BF03009796"},{"key":"2026021219120770360_j_jccm-2019-0011_ref_015_w2aab2b8c11b1b7b1ab2b1c15Aa","unstructured":"Baird MB, Schug SA. Safety aspects of postoperative pain relief. Pain Digest. 1996;6(4):219-25."},{"key":"2026021219120770360_j_jccm-2019-0011_ref_016_w2aab2b8c11b1b7b1ab2b1c16Aa","doi-asserted-by":"crossref","unstructured":"Etches RC. Respiratory depression associated with patientcontrolled analgesia: a review of eight cases. Can J Anaesth. 1994;41(2):125.","DOI":"10.1007\/BF03009805"}],"container-title":["The Journal of Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/jccm\/5\/2\/article-p66.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/jccm-2019-0011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T19:12:18Z","timestamp":1770923538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.2478\/jccm-2019-0011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,1]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,13]]},"published-print":{"date-parts":[[2019,5,13]]}},"alternative-id":["10.2478\/jccm-2019-0011"],"URL":"https:\/\/doi.org\/10.2478\/jccm-2019-0011","relation":{},"ISSN":["2393-1817"],"issn-type":[{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,1]]}}}