{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T21:05:15Z","timestamp":1770757515566,"version":"3.50.0"},"reference-count":10,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,27]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Organophosphorus poisoning is the most common poison used for suicidal attempt in Nepal. Diabetes insipidus is unusual and rare in this poisoning. This is the second case report of Diabetes insipidus developing in organophosphorus poisoning. Management of diabetes insipidus includes desmopressin and adequate fluid management.<\/jats:p>\n <\/jats:sec>\n \n Case presentation<\/jats:title>\n A 34-year-old female patient accompanied by her father presented at the Emergency department with an alleged history of ingestion of unknown amount of chlorpyrifos, cypermethrin and quinalphos. On admission, she had a Glasgow Coma Scale (GCS) of 7\/15. Her blood pressure was 110\/60 mm Hg, pulse 54\/min, respiratory rate 45\/min and saturation 35% on room air, pinpoint pupil reactive to light and bilateral crepitations. She was immediately resuscitated with two litres of normal saline and intubated with a 7 mm endotracheal tube. Atropinisation was done, and pralidoxime was started. She developed a urine output of 250-350 ml per hour with rising sodium and serum osmolality. The urine examination showed low sodium and urine specific gravity. A diagnosis of diabetes insipidus was made. There was no immediate improvement in her GCS. She was managed with 5% dextrose and subcutaneous desmopressin and was transferred out of the intensive care unit on the sixth day and was discharged from hospital on the fifteenth day.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Diabetes insipidus is a rare transient complication in organophosphorus poisoning that requires careful observation and early management with desmopressin and adequate fluid balance to improve patient outcome.<\/jats:p>\n <\/jats:sec>","DOI":"10.2478\/jccm-2019-0023","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T04:30:56Z","timestamp":1574915456000},"page":"145-148","source":"Crossref","is-referenced-by-count":1,"title":["Transient Diabetes Insipidus Following Organophosphorus Poisoning"],"prefix":"10.2478","volume":"5","author":[{"given":"Niraj Kumar","family":"Keyal","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, B & C Medical College and Teaching Hospital and Research Center , Birtamode , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amid","family":"Bhujel","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, B & C Medical College and Teaching Hospital and Research Center , Birtamode , Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2026021015593754355_j_jccm-2019-0023_ref_001_w2aab3b7b5b1b6b1ab1b5b1Aa","unstructured":"Bajracharya SR, Prasad PN, Ghimire R. Management of Organophosphorus Poisoning. J Nepal Health Res Counc. 2016;14(34):131-8."},{"key":"2026021015593754355_j_jccm-2019-0023_ref_002_w2aab3b7b5b1b6b1ab1b5b2Aa","doi-asserted-by":"crossref","unstructured":"Gyenwali D, Vaidya A, Tiwari S, Khatiwada P, Lansal DR, Giri S. Pesticide Poisoning in Chitwan, Nepal: a descriptive epidemiological study. BMC Public Health. 2017;17(1):619.","DOI":"10.1186\/s12889-017-4542-y"},{"key":"2026021015593754355_j_jccm-2019-0023_ref_003_w2aab3b7b5b1b6b1ab1b5b3Aa","unstructured":"Thapa SR, Lama P, Karki N, Khadka SB. Pattern of poisoning cases in Emergency Department of Kathmandu Medical College Teaching Hospital. Kathmandu Univ Med J. 2008;6(2):209-13."},{"key":"2026021015593754355_j_jccm-2019-0023_ref_004_w2aab3b7b5b1b6b1ab1b5b4Aa","doi-asserted-by":"crossref","unstructured":"Nazima SN, Bashir Y, Nabi S, Bashir N.Intensive care management of organophosphorus poisoning patients: an experience from tertiary care center. 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