{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:11:18Z","timestamp":1783001478918,"version":"3.54.5"},"reference-count":46,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jccm-2020-0018_s_006_w2aab3b7c30b1b6b1aab1c15b1Aa\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Peptic mucosal damage induced by acute stress is a serious cause of morbidity and mortality in critically ill patients. The study aimed to investigate the protective, antioxidant and anti-inflammatory effects of pretreatment with Chios mastic gum (CMG), a traditionally consumed herbal resin naturally deriving from the trunk of Pistacia Lentiscus var. Chia compared to Omeprazole, a standard medication used in the prevention and treatment of gastritis, against the effects of cold restraint stress (CRS) in rat gastric and colonic mucosa.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2020-0018_s_007_w2aab3b7c30b1b6b1aab1c15b2Aa\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-one male Wistar rats were randomly assigned to three groups: Control (C), Omeprazole (O), and CMG (M), according to the pre-treatment regime, and were subjected to CRS at 4<jats:sup>0<\/jats:sup>C for 3 hours. The gastric and colonic mucosal lesions were histologically assessed. ELISA measured blood concentrations of TNF-\u03b1, IL-1\u03b2, peroxidase, superoxide dismutase (SOD) and total antioxidant capacity (TEAC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2020-0018_s_008_w2aab3b7c30b1b6b1aab1c15b3Aa\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In both groups, O and M, gastric mucosal hyperemia, haemorrhagic infiltration and mucosal oedema, as well as colonic mucosal hyperaemia and haemorrhagic infiltration were significantly reduced compared to the controls (p&lt;0.05). No significant differences were observed between Groups O and M. TNF-\u03b1 levels were significantly lower in group M compared to Group O (p=0.013). IL-1\u03b2 levels were significantly depressed in groups M and O compared to control (p\u2264 0.001). The activity of both peroxidase and SOD enzymes decreased in group M compared to group O (p= 0.043 and p=0.047 respectively) and the control (p=0.018 and p&lt; 0.001 respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2020-0018_s_009_w2aab3b7c30b1b6b1aab1c15b4Aa\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The natural Chios mastic gum is a promising nutritional supplement with protective properties to the peptic mucosa against CRS, exerting anti-inflammatory and antioxidant effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jccm-2020-0018","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T14:22:09Z","timestamp":1590502929000},"page":"100-110","source":"Crossref","is-referenced-by-count":7,"title":["The Use of Pistacia Lentiscus Chia Resin versus Omeprazole in Protecting Male Rats Peptic Mucosa against Cold Restraint Stress"],"prefix":"10.2478","volume":"6","author":[{"given":"Despoina","family":"Kakagia","sequence":"first","affiliation":[{"name":"Democritus University of Thrace Faculty of Medicine Alexandroupolis , Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Papalois","sequence":"additional","affiliation":[{"name":"Elpen Research Centre , Elpen Pharmaceuticals , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lambropoulou","sequence":"additional","affiliation":[{"name":"Department of Histology- Embryology, Democritus University of Thrace, Faculty of Medicine , Alexandroupolis , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotini","family":"Papachristou","sequence":"additional","affiliation":[{"name":"Democritus University of Thrace Faculty of Medicine Alexandroupolis , Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Trypsiannis","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Democritus University of Thrace, Faculty of Medicine , Alexandropoulis , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Anagnostopoulos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Democritus University of Thrace, Faculty of Medicine , Alexandroupolis , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Pitiakoudis","sequence":"additional","affiliation":[{"name":"Democritus University of Thrace Faculty of Medicine Alexandroupolis , Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Tsaroucha","sequence":"additional","affiliation":[{"name":"Democritus University of Thrace Faculty of Medicine Alexandroupolis , Alexandroupolis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,5,6]]},"reference":[{"key":"2024080917293492696_j_jccm-2020-0018_ref_001_w2aab3b7c30b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Guth PH. 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