{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:09:22Z","timestamp":1714522162749},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jccm-2021-0021_s_006\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2021-0021_s_007\">\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, T\u00eergu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2021-0021_s_008\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p&lt;0.05 for all parameters.)<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2021-0021_s_009\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jccm-2021-0021","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T03:55:53Z","timestamp":1628222153000},"page":"211-216","source":"Crossref","is-referenced-by-count":2,"title":["Impact of the Severity of Liver Injury in COVID-19 Patients Admitted to an Intensive Care Unit During the SARS-CoV2 Pandemic Outbreak"],"prefix":"10.2478","volume":"7","author":[{"given":"Adina","family":"Roman","sequence":"first","affiliation":[{"name":"Mures County Hospital , Targu Mures , Romania"},{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures , Targu Mures , Romania"},{"name":"Doctoral School, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures , Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Septimiu","family":"Moldovan","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures , Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ario","family":"Santini","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures , Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Stoian","sequence":"additional","affiliation":[{"name":"Mures County Hospital , Targu Mures , Romania"},{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures , Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Dobru","sequence":"additional","affiliation":[{"name":"Mures County Hospital , Targu Mures , Romania"},{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures , Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"2024043014491381426_j_jccm-2021-0021_ref_001","doi-asserted-by":"crossref","unstructured":"Fan Z, Chen L, Li J et al. 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