{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:54:48Z","timestamp":1764172488946},"reference-count":12,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T00:00:00Z","timestamp":1636761600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jccm-2021-0039_s_005\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The COVID-19 pandemic has put increased stress on medical systems, infrastructure, and the public in expected and unexpected ways. This case report summarises an unexpected case of methanol poisoning from hand sanitiser ingestion due to changes in industry regulations, increased demand for cleaning products and severe psychosocial stressors brought on by the pandemic. Severe methanol toxicity results in profound metabolic disturbances, damage to the retina and optic nerves, and potentially death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2021-0039_s_006\">\n                  <jats:title>Case Presentation<\/jats:title>\n                  <jats:p>The patient was a 26-year-old male with alcohol use disorder who presented with one day of nausea, vomiting, and abdominal pain after consuming hand sanitiser. Within a few hours, the patient had suffered multiple seizures, cardiac arrests and required admission to the ICU for emergent management of methanol poisoning. EEG and brain perfusion imaging were performed to confirm brain death, given concerns about the cranial nerve exam after methanol poisoning.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2021-0039_s_007\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>While rare, methanol toxicity remains a potentially fatal poisoning in the United States and worldwide. When healthcare and public resources are strained, healthcare professionals must consider particularly abnormal presentations. In patients suspected of brain death from methanol toxicity, cranial nerve examination may be unreliable. Therefore, additional testing is necessary to confirm brain death.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jccm-2021-0039","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T22:16:55Z","timestamp":1636928215000},"page":"66-70","source":"Crossref","is-referenced-by-count":3,"title":["Methanol Poisoning Leading to Brain Death: A Case Report"],"prefix":"10.2478","volume":"8","author":[{"given":"Jakub","family":"Glowala","sequence":"first","affiliation":[{"name":"McGaw Medical Center of Northwestern University , Chicago , IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy B.","family":"Richards","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center , Boston , MA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"2024042806001180807_j_jccm-2021-0039_ref_001","doi-asserted-by":"crossref","unstructured":"Narasimha VL, Shukla L, Mukherjee D, et al. Complicated Alcohol Withdrawal\u2014An Unintended Consequence of COVID-19 Lockdown. Alcohol Alcohol. 2020 Jun 25;55(4):350353.","DOI":"10.1093\/alcalc\/agaa042"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_002","unstructured":"Chiu A, Shepherd K, Shammas B, Itkowitz C. Trump claims controversial comment about injecting disinfectants was \u2018sarcastic.\u2019 Washington Post. Accessed August 3, 2020. https:\/\/www.washingtonpost.com\/nation\/2020\/04\/24\/disinfectant-injection-coronavirus-trump\/"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_003","doi-asserted-by":"crossref","unstructured":"Davis LE, Hudson D, Benson BE, Easom LAJ, Coleman JK. Methanol Poisoning Exposures in the United States: 1993\u2013 1998. . J Toxicol Clin Toxicol. 2002;40(4):499-505.","DOI":"10.1081\/CLT-120006753"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_004","doi-asserted-by":"crossref","unstructured":"Fill MM, Seger DL, Dunn JR, Schaffner W, Jones TF. Notes from the Field: Intoxication and Deaths Associated with Ingestion of a Racing Fuel and Carbonated Soft Drink Mixture - Tennessee, January 2016. MMWR Morb Mortal Wkly Rep. 2016 Jun 10;65(22):585-6.","DOI":"10.15585\/mmwr.mm6522a4"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_005","unstructured":"Methyl Alcohol (Methanol) | NIOSH | CDC. Published February 24, 2020. Accessed July 19, 2020. https:\/\/www.cdc.gov\/niosh\/topics\/methyl-alcohol\/default.html"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_006","unstructured":"FDA Says Avoid These 9 Hand Sanitisers That Contain Toxic Methanol. Healthline. Published July 29, 2020. Accessed December 29, 2020. https:\/\/www.healthline.com\/health-news\/fda-says-avoid-9-hand-sanitizers-that-contain-toxic-methanol"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_007","unstructured":"Ashurst JV, Nappe TM. Methanol Toxicity. In: StatPearls. StatPearls Publishing; 2020. Accessed July 19, 2020. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482121\/"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_008","doi-asserted-by":"crossref","unstructured":"M\u00e9garbane B. Treatment of patients with ethylene glycol or methanol poisoning: focus on fomepizole. Open Access Emerg Med. 2010;2:67-75.","DOI":"10.2147\/OAEM.S5346"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_009","doi-asserted-by":"crossref","unstructured":"Gonda A, Gault H, Churchill D, Hollomby D. Hemodialysis for methanol intoxication. Am J Med. 1978;64(5):749-758.","DOI":"10.1016\/0002-9343(78)90513-2"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_010","doi-asserted-by":"crossref","unstructured":"Theobald J, Lim C. Folate as an Adjuvant Therapy in Methanol Poisoning. Nutrition in Clinical Practice. 2019;34(4):521-527.","DOI":"10.1002\/ncp.10329"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_011","doi-asserted-by":"crossref","unstructured":"Grzybowski A, Z\u00fclsdorf M, Wilhelm H, Tonagel F. Toxic optic neuropathies: an updated review. Acta Ophthalmol. 2015;93(5):402-410.","DOI":"10.1111\/aos.12515"},{"key":"2024042806001180807_j_jccm-2021-0039_ref_012","unstructured":"Research C for DE and. FDA Updates on Hand Sanitisers with Methanol. FDA. Published online July 17, 2020. Accessed July 19, 2020. https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-updates-hand-sanitizers-methanol"}],"container-title":["The Journal of Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/jccm-2021-0039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T06:00:21Z","timestamp":1714284021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.2478\/jccm-2021-0039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,13]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,11,13]]},"published-print":{"date-parts":[[2022,2,9]]}},"alternative-id":["10.2478\/jccm-2021-0039"],"URL":"https:\/\/doi.org\/10.2478\/jccm-2021-0039","relation":{},"ISSN":["2393-1817"],"issn-type":[{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,13]]}}}