{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:38:11Z","timestamp":1785580691146,"version":"3.56.0"},"reference-count":8,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jccm-2022-0004_s_005\">\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Diffuse alveolar haemorrhage (DAH) is a potentially life-threatening disease, characterized by diffuse accumulation of red blood cells within the alveoli. It can be caused by a variety of disorders. In case DAH results in severe respiratory failure, veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be required. Since VV-ECMO coincides with the need for anticoagulation therapy, this results in a major clinical challenge in DAH patients with hemoptysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2022-0004_s_006\">\n                  <jats:title>Case presentation<\/jats:title>\n                  <jats:p>We report a patient case with severe DAH-induced acute respiratory failure and hemoptysis in need for VV-ECMO complicated by life-threatening membrane oxygenator thrombosis. The DAH-induced hemoptysis was successfully treated with local bronchoscopic recombinant factor VIIa (rFVIIa), allowing systemic anticoagulation to prevent further membrane oxygenator thrombosis. Neither systemic clinical side effects nor differences in the serum coagulation markers occurred after applying recombinant factor VIIa (rFVIIa) treatment endobronchially.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jccm-2022-0004_s_007\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This is, to our knowledge, the first case that reports the use of rFVIIa in a patient with DAH due to vasculitis and in need for VV-ECMO complicated by membrane oxygenator thrombosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jccm-2022-0004","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T20:31:45Z","timestamp":1652301105000},"page":"123-125","source":"Crossref","is-referenced-by-count":2,"title":["Bronchoscopic Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage-induced Acute Respiratory Failure in MPO-ANCA Vasculitis: A Case Report"],"prefix":"10.2478","volume":"8","author":[{"given":"Illaa","family":"Smesseim","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam and Free University Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titia","family":"Schaepman-Ruys","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam and Free University Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Duitman","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam and Free University Amsterdam , Amsterdam The Netherlands"},{"name":"Department of Experimental Immunology (EXIM), Amsterdam University Medical Center, University of Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosta","family":"Vegting","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Nephrology, Location Meibergdreef Amsterdam UMC, University of Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorinde","family":"Raasveld","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Amsterdam University Medical Centers, University of Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hilhorst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Nephrology, Location Meibergdreef Amsterdam UMC, University of Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Amsterdam University Medical Centers, University of Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josien","family":"van Es","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam and Free University Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bonta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam and Free University Amsterdam , Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"2023122812402473025_j_jccm-2022-0004_ref_001","doi-asserted-by":"crossref","unstructured":"Mart\u00ednez-Mart\u00ednez MU, Oostdam DAH, Abud-Mendoza C. Diffuse Alveolar Hemorrhage in Autoimmune Diseases. Curr Rheumatol Rep. 2017;19(5):27.","DOI":"10.1007\/s11926-017-0651-y"},{"key":"2023122812402473025_j_jccm-2022-0004_ref_002","doi-asserted-by":"crossref","unstructured":"Lara AR, Schwarz MI. Diffuse alveolar hemorrhage. Chest. 2010;137(5):1164-1171.","DOI":"10.1378\/chest.08-2084"},{"key":"2023122812402473025_j_jccm-2022-0004_ref_003","doi-asserted-by":"crossref","unstructured":"Gallagher H, Kwan JT, Jayne DR. Pulmonary renal syndrome: a 4-year, single-center experience. Am J Kidney Dis. 2002;39(1):42-47.","DOI":"10.1053\/ajkd.2002.29876"},{"key":"2023122812402473025_j_jccm-2022-0004_ref_004","unstructured":"Alexandre AT, Vale A, Gomes T. Diffuse alveolar hemorrhage: how relevant is etiology?. Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(1):47-52."},{"key":"2023122812402473025_j_jccm-2022-0004_ref_005","doi-asserted-by":"crossref","unstructured":"Levi M, van Der POLL T, ten CATE H, et al. Differential effects of anti-cytokine treatment on bronchoalveolar hemostasis in endotoxemic chimpanzees. Am J Respir Crit Care Med. 1998;158(1):92-98.","DOI":"10.1164\/ajrccm.158.1.9709007"},{"key":"2023122812402473025_j_jccm-2022-0004_ref_006","doi-asserted-by":"crossref","unstructured":"Heslet L, Nielsen JD, Levi M, Sengel\u00f8v H, Johansson PI. Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage. Crit Care. 2006;10(6):177.","DOI":"10.1186\/cc5132"},{"key":"2023122812402473025_j_jccm-2022-0004_ref_007","doi-asserted-by":"crossref","unstructured":"Marti-Carvajal AJ, Salanti G, Marti-Carvajal PI. Human recombinant activated factor VII for upper gastrointestinal bleeding in patients with liver diseases. Cochrane Database Syst Rev. 2007;(1):CD004887.","DOI":"10.1002\/14651858.CD004887.pub2"},{"key":"2023122812402473025_j_jccm-2022-0004_ref_008","doi-asserted-by":"crossref","unstructured":"Hedner U. Recombinant activated factor VII: 30 years of research and innovation. Blood Rev. 2015;29 Suppl 1:S4-S8.","DOI":"10.1016\/S0268-960X(15)30002-3"}],"container-title":["The Journal of Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/jccm-2022-0004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T12:46:39Z","timestamp":1703767599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.2478\/jccm-2022-0004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,5,12]]},"published-print":{"date-parts":[[2022,5,12]]}},"alternative-id":["10.2478\/jccm-2022-0004"],"URL":"https:\/\/doi.org\/10.2478\/jccm-2022-0004","relation":{},"ISSN":["2393-1817"],"issn-type":[{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}