{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:08Z","timestamp":1787025248644,"version":"build-2736575974"},"reference-count":21,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sheehan\u2019s syndrome is a life-threatening endocrine emergency seen in postpartum females secondary to ischemic pituitary necrosis. It is a frequent cause of hypopituitarism in developing countries that occurs secondary to postpartum haemorrhage (PPH). Patients with Sheehan\u2019s syndrome often present with organ dysfunctions in critical care settings, secondary to stressors precipitating the underlying hormonal deficiencies. The initial clinical picture of Sheehan\u2019s syndrome may mimic some other disease, leading to misdiagnosis and diagnostic delay. Strict vigilance, timely diagnosis, and appropriate management are essential to avoid diagnostic delay and to improve the patient outcome. In this case series, we describe 5 cases of previously undiagnosed Sheehan\u2019s syndrome (including young, middle aged and postmenopausal females) that presented to critical care and emergency settings with organ failures.<\/jats:p>","DOI":"10.2478\/jccm-2022-0018","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T01:14:14Z","timestamp":1661130854000},"page":"214-222","source":"Crossref","is-referenced-by-count":9,"title":["A Challenging Diagnosis of Sheehan\u2019s Syndrome in Non-obstetric Critical Care and Emergency Settings: A Case Series of Five Patients with Varied Presentations"],"prefix":"10.2478","volume":"8","author":[{"given":"Suhail Sarwar","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, King George Medical University , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nibu","family":"Dominic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aster Medcity , Kochi , Kerala , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukriti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, King George Medical University , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauser","family":"Usman","sequence":"additional","affiliation":[{"name":"Endocrinology Division, King George Medical University , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Saran","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, King George Medical University , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, King George Medical University , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Gurjar","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Nabeel","family":"Muzaffar","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, King George Medical University , Lucknow , Uttar Pradesh , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"2024042805511552329_j_jccm-2022-0018_ref_001","doi-asserted-by":"crossref","unstructured":"Cooke RT. Simmonds\u2019s Disease due to Post-partum Necrosis of Anterior Pituitary. Br Med J. 1945;2(4423):493-494.","DOI":"10.1136\/bmj.2.4423.493"},{"key":"2024042805511552329_j_jccm-2022-0018_ref_002","unstructured":"Laway BA, Baba MS. Sheehan syndrome. J Pak Med Assoc. 2021;71(4):1282-12568."},{"key":"2024042805511552329_j_jccm-2022-0018_ref_003","doi-asserted-by":"crossref","unstructured":"Jose M, Amir S, Desai R. Chronic Sheehan\u2019s Syndrome - A Differential to be Considered in Clinical Practice in Women with a History of Postpartum Hemorrhage. Cureus. 2019;11(12):e6290.","DOI":"10.7759\/cureus.6290"},{"key":"2024042805511552329_j_jccm-2022-0018_ref_004","doi-asserted-by":"crossref","unstructured":"Kele\u015ftimur F. Sheehan\u2019s syndrome. Pituitary. 2003;6(4):181-188.","DOI":"10.1023\/B:PITU.0000023425.20854.8e"},{"key":"2024042805511552329_j_jccm-2022-0018_ref_005","doi-asserted-by":"crossref","unstructured":"Karaca Z, Laway BA, Dokmetas HS, et al. Sheehan syndrome. 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Int J Endocrinol. 2018;2018:8415860.","DOI":"10.1155\/2018\/8415860"},{"key":"2024042805511552329_j_jccm-2022-0018_ref_009","doi-asserted-by":"crossref","unstructured":"Sethuram R, Guilfoil DS, Amori R, et al. Sheehan Syndrome: An Unusual Presentation Without Inciting Factors. Womens Health Rep (New Rochelle). 2020;1(1):287-292.","DOI":"10.1089\/whr.2019.0028"},{"key":"2024042805511552329_j_jccm-2022-0018_ref_010","doi-asserted-by":"crossref","unstructured":"de Silva NL, Galhenage J, Dayabandara M, Somasundaram N. Sheehan Syndrome Presenting with Psychotic Manifestations Mimicking Schizophrenia in a Young Female: A Case Report and Review of the Literature. Case Rep Endocrinol. 2020 ;2020:8840938.","DOI":"10.1155\/2020\/8840938"},{"key":"2024042805511552329_j_jccm-2022-0018_ref_011","doi-asserted-by":"crossref","unstructured":"Diri H, Tanriverdi F, Karaca Z, et al. Extensive investigation of 114 patients with Sheehan\u2019s syndrome: a continuing disorder. 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Journal of Chitwan Medical College. 2013;3(2):49-50.","DOI":"10.3126\/jcmc.v3i2.8444"}],"container-title":["The Journal of Critical Care Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciendo.com\/pdf\/10.2478\/jccm-2022-0018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T01:51:47Z","timestamp":1714269107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.2478\/jccm-2022-0018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,8,12]]},"published-print":{"date-parts":[[2022,8,12]]}},"alternative-id":["10.2478\/jccm-2022-0018"],"URL":"https:\/\/doi.org\/10.2478\/jccm-2022-0018","relation":{},"ISSN":["2393-1817"],"issn-type":[{"value":"2393-1817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]}}}