{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:57:30Z","timestamp":1793998650982,"version":"4.8.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Traumatic brain injury (TBI) has become a significant cause of death and morbidity in childhood since the elucidation of infectious causes within the last century. Mortality rates in this population decreased over time due to developments in technology and effective treatment modalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim of the study<\/jats:title>\n                  <jats:p>This retrospective cohort study aimed to describe the volume, severity and mechanism of all hospital-admitted pediatric TBI patients at a university hospital over a 5-year period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and Methods<\/jats:title>\n                  <jats:p>This was a single-center, retrospective cohort study including 90 pediatric patients with TBI admitted to a tertiary care PICU. The patients\u2019 demographic data, injury mechanisms, disease and trauma severity scores, initiation of enteral nutrition and outcome measures such as hospital stay, PICU stay, duration of mechanical ventilation, mortality, and Glasgow Outcome Scale (GOS) were also recorded. Late enteral nutrition was defined as initiation of enteral feeding after 48 hours of hospitalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 90 patients included in the cohort, 60% had mild TBI, 21.1% had moderate TBI and 18.9% had severe TBI. Their mean age was 69 months (3\u2013210 months). TBI was isolated in 34 (37.8%) patients and observed as a part of multisystemic trauma in 56 (62.2%). The most commonly involved site in multisystemic injury was the thorax (33.3%). The length of hospitalization in the late enteral nutrition group was significantly higher than that in the early nutrition group, while the PICU stay was not significantly different between the two groups. The multiple logistic regression analysis found a significant relationship between GOS-3rd month and PIM3 score, the presence of diffuse axonal injury and the need for CPR in the first 24 h of hospitalization.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although our study showed that delayed enteral nutrition did not affect neurologic outcome, it may lead to prolonged hospitalization and increased hospital costs. High PIM3 scores and diffuse axonal injury are both associated with worse neurologic outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jccm-2023-0027","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:14:28Z","timestamp":1699956868000},"page":"252-261","source":"Crossref","is-referenced-by-count":5,"title":["A Retrospective Cohort Study of Traumatic Brain Injury in Children: A Single-Institution Experience and Determinants of Neurologic Outcome"],"prefix":"10.2478","volume":"9","author":[{"given":"Merve","family":"Misirlioglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care , Mersin University Faculty of Medicine , Mersin , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dincer","family":"Yildizdas","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozden Ozgur","family":"Horoz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayri Levent","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Incecik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazhar","family":"Ozsoy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Yontem","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevcan","family":"Bilen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Emergency , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Silay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , Cukurova University Faculty of Medicine , Adana , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"2024042707544554299_j_jccm-2023-0027_ref_001","doi-asserted-by":"crossref","unstructured":"Hon KL, Huang S, Poon WS, Cheung HM, Ip P, Zee B. 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