{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:08:39Z","timestamp":1774688919133,"version":"3.50.1"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Proper management of sepsis poses a challenge even today, with early diagnosis and targeted treatment being the most important steps. Easy, cost-effective bedside tools are needed in order to pinpoint towards the outcome of sepsis or septic shock.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim of study<\/jats:title>\n                  <jats:p>This study aims to find a correlation between Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) severity scores, the Neutrophil-Lymphocytes Ratio (NLR) and carboxyhaemoglobin (COHb) levels in septic or septic shock patients with the scope of establishing a bed side cost-effective prognostic tool.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>A pilot, prospective, observational, and ongoing study was conducted on 61 patients admitted with sepsis or septic shock according to the SEPSIS 3 Consensus definition. We followed clinical and paraclinical parameters on day 1 (D1) and day 5 (D5) after meeting the inclusion criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>On D1 we found a statistically significant positive correlation between each severity score (p &lt;0.0001), r = 0.7287 for SOFA vs. APACHE II with CI: 0.5841\u20130.8285, r = 0.6862 for SOFA vs. SAPS II with CI: 0.5251\u20130.7998 and r = 0.8534 for APACHE II vs. SAPS II with CI: 0.7663 to 0.9097. On D5 we observed similar results: a significant positive correlation between each severity score (p &lt;0.0001), with r = 0.7877 for SOFA vs. APACHE II with CI: 0.6283 to 0.8836, r = 0.8210 for SOFA vs. SAPS II with CI: 0.6822 to 0.9027 and r = 0.8880 for APACHE II vs. SAPS II., CI: 0.7952 to 0.9401. Nil correlation was found between the severity scores, NLR and COHb on D1 and D5.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cost-effective bedside tools to pinpoint towards the outcome of sepsis are yet to be found, however the positive correlation between the severity scores point out to a combination of such tools for prognosis prediction of septic or septic shock patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jccm-2023-0031","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T10:14:01Z","timestamp":1699956841000},"page":"239-251","source":"Crossref","is-referenced-by-count":2,"title":["Is Carboxyhaemoglobin an Effective Bedside Prognostic Tool for Sepsis and Septic Shock Patients?"],"prefix":"10.2478","volume":"9","author":[{"given":"Bianca-Liana","family":"Grigorescu","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care , George Emil Palade University of Medicine , Pharmacy, Science, and Technology of Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana","family":"Coman","sequence":"additional","affiliation":[{"name":"Department of Simulation Applied in Medicine , George Emil Palade University of Medicine , Pharmacy, Science, and Technology of Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca Meda","family":"V\u0103sie\u0219iu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases , George Emil Palade University of Medicine , Pharmacy, Science, and Technology of Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Bac\u00e2rea","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology , George Emil Palade University of Medicine , Pharmacy, Science, and Technology of Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Petri\u0219or","sequence":"additional","affiliation":[{"name":"Department of Simulation Applied in Medicine , George Emil Palade University of Medicine , Pharmacy, Science, and Technology of Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"S\u0103pl\u0103can","sequence":"additional","affiliation":[{"name":"County Emergency Clinical Hospital , Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raluca \u0218tefania","family":"Fodor","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care , George Emil Palade University of Medicine , Pharmacy, Science, and Technology of Targu Mures , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,11,14]]},"reference":[{"key":"2024042707060155933_j_jccm-2023-0031_ref_001","doi-asserted-by":"crossref","unstructured":"Singer M, Deutschman CS, Seymour CW, et al. 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