{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:01:17Z","timestamp":1771113677789,"version":"3.50.1"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Brain abscess is a serious condition in children, leading to rapid deterioration, and permanent neurological damage associated with significant morbidity and mortality. Current management protocols for brain abscesses focus on intravenous antibiotics and surgical excision and drainage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 12-year-old adolescent male who had headache and photophobia and was diagnosed with multiple brain abscesses and was refractory to conventional medical and neurosurgical intervention. A single dose of 10 mg vancomycin was administered through endo-ventricular drain, resulting in resolution of abscesses and alleviation of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We describe the first instance of intraventricular vancomycin use in the pediatric age group for the treatment of multiple brain abscesses. Given the variability in dosing reported in the literature, our case report warrants further studies to standardize dosage for this rare intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/jccm-2024-0046","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T10:55:12Z","timestamp":1747306512000},"page":"198-201","source":"Crossref","is-referenced-by-count":0,"title":["The use of intraventricular vancomycin in subacute brain abscess in an adolescent male: A case report"],"prefix":"10.2478","volume":"11","author":[{"given":"Tomas","family":"Leng","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim Serhat","family":"Karakus","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine , Mayo Clinic , Rochester , MN , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"2026021423053507941_j_jccm-2024-0046_ref_001","doi-asserted-by":"crossref","unstructured":"Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G. Brain abscess in pediatric age: a review. Childs Nerv Syst. 2019;35:1117\u201328.","DOI":"10.1007\/s00381-019-04182-4"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_002","doi-asserted-by":"crossref","unstructured":"Omar AT, 2nd, Khu KJO. Successful management of intraventricular rupture of pyogenic brain abscess (IVROBA): Systematic review and illustrative case. J Clin Neurosci. 2020;71:191\u20138.","DOI":"10.1016\/j.jocn.2019.08.067"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_003","doi-asserted-by":"crossref","unstructured":"Liu SP, Xiao J, Liu YL, et al. Systematic review of efficacy, safety and pharmacokinetics of intravenous and intraventricular vancomycin for central nervous system infections. Front Pharmacol. 2022;13:1056148.","DOI":"10.3389\/fphar.2022.1056148"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_004","doi-asserted-by":"crossref","unstructured":"Petti CA, Simmon KE, Bender J, et al. Culture-Negative intracerebral abscesses in children and adolescents from Streptococcus anginosus group infection: a case series. Clin Infect Dis. 2008;46:1578\u201380.","DOI":"10.1086\/587655"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_005","doi-asserted-by":"crossref","unstructured":"Watson M. Streptococcal Intermedius Brain Abscesses In An Adolescent Male With Histoplasma Infection. Pediatric Oncall. 2012;9.","DOI":"10.7199\/ped.oncall.2012.62"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_006","doi-asserted-by":"crossref","unstructured":"Bodilsen J, D\u2019Alessandris QG, Humphreys H, et al. European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults. Clin Microbiol Infect. 2024;30:66\u201389.","DOI":"10.1016\/j.cmi.2024.01.026"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_007","doi-asserted-by":"crossref","unstructured":"Bonilla FA. Interpretation of lymphocyte proliferation tests. Ann Allergy Asthma Immunol. 2008;101:101\u20134.","DOI":"10.1016\/S1081-1206(10)60842-3"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_008","doi-asserted-by":"crossref","unstructured":"Nagl M, Neher C, Hager J, Pfausler B, Schmutzhard E, Allerberger F. Bactericidal activity of vancomycin in cerebrospinal fluid. Antimicrob Agents Chemother. 1999;43:1932\u20134.","DOI":"10.1128\/AAC.43.8.1932"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_009","unstructured":"Reiter PD, Doron MW. Vancomycin cerebrospinal fluid concentrations after intravenous administration in premature infants. J Perinatol. 1996;16:331\u20135."},{"key":"2026021423053507941_j_jccm-2024-0046_ref_010","doi-asserted-by":"crossref","unstructured":"Doan N, Nguyen H, Luyuan L, Shabani S, Gelsomino M, Johnson V. Good Outcomes with the Intraventricular Vancomycin Therapy in a Patient with Ruptured Brain Abscesses. Asian J Neurosurg. 2018;13:396\u20139.","DOI":"10.4103\/1793-5482.185065"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_011","doi-asserted-by":"crossref","unstructured":"Deniz M, Tap\u0131s\u0131z A, B\u00f6rcek A, Tezer H. Intraventricular treatment of paediatric meningitis due to extensively drug-resistant Gram-negative bacteria: two case reports and review of the literature. J Chemother. 2021;33:509\u201316.","DOI":"10.1080\/1120009X.2021.1920249"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_012","doi-asserted-by":"crossref","unstructured":"Parasuraman JM, Albur M, Fellows G, Heep A. Monitoring intraventricular vancomycin for ventriculostomy access device infection in preterm infants. Childs Nerv Syst. 2018;34:473\u20139.","DOI":"10.1007\/s00381-017-3623-7"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_013","doi-asserted-by":"crossref","unstructured":"Bafeltowska JJ, Buszman E, Mandat KM, Hawranek JK. Therapeutic vancomycin monitoring in children with hydrocephalus during treatment of shunt infections. Surg Neurol. 2004;62:142\u201350; discussion 50.","DOI":"10.1016\/j.surneu.2003.11.014"},{"key":"2026021423053507941_j_jccm-2024-0046_ref_014","doi-asserted-by":"crossref","unstructured":"Ng K, Mabasa VH, Chow I, Ensom MH. Systematic review of efficacy, pharmacokinetics, and administration of intraventricular vancomycin in adults. 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