{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:28:18Z","timestamp":1771270098067,"version":"3.50.1"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Warburg effect is a rare but often fatal condition in patients with malignancies. This phenomenon, known as type B lactic acidosis, is defined by lactatemia without tissue hypoxia or hypoperfusion, in contrast to type A lactic acidosis, which usually results from either or both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A male patient in his seventies with a newly diagnosed diffuse large B-cell lymphoma is admitted to the intensive care unit due to severe metabolic derangements with hypoglycemia and lactatemia. Extensive investigations ruled out alternative etiologies, strongly suggesting the Warburg effects as the underlying mechanism. Despite hemodynamic instability, chemotherapy was initiated and resulted in initial clinical improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We propose a stepwise approach to improve the management of patients with suspected type B lactic acidosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/jccm-2025-0045","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:03:29Z","timestamp":1771265009000},"page":"135-140","source":"Crossref","is-referenced-by-count":0,"title":["Warburg effect in B-cell lymphoma: A case report and proposed management plan"],"prefix":"10.2478","volume":"12","author":[{"given":"Stefan","family":"Gligor","sequence":"first","affiliation":[{"name":"Baden Cantonal Hospital , Baden , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"Baden Cantonal Hospital , Baden , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Ballova","sequence":"additional","affiliation":[{"name":"Baden Cantonal Hospital , Baden , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Kopp","family":"Lugli","sequence":"additional","affiliation":[{"name":"Baden Cantonal Hospital , Baden , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"2026021618184943370_j_jccm-2025-0045_ref_001","doi-asserted-by":"crossref","unstructured":"Pascale RM, Calvisi DF, Simile MM, Feo CF, Feo F. The Warburg Effect 97 Years after Its Discovery. Cancers (Basel). 2020;12(10).","DOI":"10.3390\/cancers12102819"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_002","doi-asserted-by":"crossref","unstructured":"Warburg O. The metabolism of carcinoma cells. The Journal of Cancer Research. 1925;9(1):148\u201363.","DOI":"10.1158\/jcr.1925.148"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_003","doi-asserted-by":"crossref","unstructured":"Warburg O, Minami S. Versuche an \u00fcberlebendem carcinom-gewebe. Klinische Wochenschrift. 1923;2(17):776\u20137.","DOI":"10.1007\/BF01712130"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_004","doi-asserted-by":"crossref","unstructured":"Vaupel P, Multhoff G. Revisiting the Warburg effect: historical dogma versus current understanding. J Physiol. 2021;599(6):1745\u201357.","DOI":"10.1113\/JP278810"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_005","doi-asserted-by":"crossref","unstructured":"Koppenol WH, Bounds PL, Dang CV. Otto Warburg\u2019s contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11(5):325\u201337.","DOI":"10.1038\/nrc3038"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_006","doi-asserted-by":"crossref","unstructured":"Bar-Or D, Carrick M, Tanner A, 2nd, Lieser MJ, Rael LT, Brody E. Overcoming the Warburg Effect: Is it the key to survival in sepsis? J Crit Care. 2018;43:197\u2013201.","DOI":"10.1016\/j.jcrc.2017.09.012"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_007","doi-asserted-by":"crossref","unstructured":"Chaba A, Fodil S, Lemiale V, et al. Clinical Warburg effect in lymphoma patients admitted to intensive care unit. Ann Intensive Care. 2023;13(1):97.","DOI":"10.1186\/s13613-023-01192-z"},{"key":"2026021618184943370_j_jccm-2025-0045_ref_008","doi-asserted-by":"crossref","unstructured":"Zhou Z, Sehn LH, Rademaker AW, et al. 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