{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:07:43Z","timestamp":1766362063706},"reference-count":74,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"3","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec id=\"j_jomb-2018-0042_s_005\"><jats:title>Background<\/jats:title><jats:p>The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11\/Eotaxin-1 in postmenopausal osteoporosis.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2018-0042_s_006\"><jats:title>Objective<\/jats:title><jats:p>The scope of this study was to explore the relationship between serum CCL11\/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2018-0042_s_007\"><jats:title>Methods<\/jats:title><jats:p>A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85 healthy controls inner child-bearing age were enrolled as control. The Dual-energy X-ray absorptiometry was used to examine the BMDs at the femoral neck, lumbar spine 1-4 and total hip of all participants. Serum CCL11\/Eotaxin-1 levels were examined by enzyme-linked immunosorbent assay. We also included inflammation marker interleukin-6 (IL-6) as well as a serum marker of bone resorption C-telopeptide cross-linked collagen type 1 (CTX-1). The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were recorded to evaluate the clinical severity in POMP females.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2018-0042_s_008\"><jats:title>Results<\/jats:title><jats:p>Serum CCL11\/Eotaxin-1 levels were significantly elevated in postmenopausal osteoporotic patients PMOP patients compared with PMNOP and healthy controls. We observed a significant negative correlation of serum CCL11\/Eotaxin-1 levels with lumbar spine, femoral neck and total hip BMD. Furthermore, serum CCL11\/ Eotaxin-1 concentrations were also positively related to the VAS and ODI scores. Last, serum CCL11\/ Eotaxin-1 concentrations were positively associated with IL-6 and CTX-1 levels. These correlations remain significant after adjusting for age and BMI. Multivariate linear regression analysis demonstrated that CCL11\/Eotaxin-1 could serve as an independent marker.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2018-0042_s_009\"><jats:title>Conclusions<\/jats:title><jats:p>Serum CCL 11\/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Therapeutics targeting CCL11\/Eotaxin-1 and its related signalling way to prevent and slow progression of PMOP deserve further study.<\/jats:p><\/jats:sec>","DOI":"10.2478\/jomb-2018-0042","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T09:30:43Z","timestamp":1547112643000},"page":"353-360","source":"Crossref","is-referenced-by-count":8,"title":["Serum C-C motif ligand 11\/eotaxin-1 may serve as a candidate biomarker for postmenopausal 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