{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:19:10Z","timestamp":1790079550521,"version":"4.0.1"},"reference-count":30,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"4","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,22]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec id=\"j_jomb-2018-0052_s_006\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of this study is to investigate whether or not reticulocyte hemoglobin equivalent (RET-He) is a superior indicator of blood count and other iron parameters in terms of diagnosing iron deficiency (ID) and iron deficiency anemia (IDA), and thus evaluating a patient\u2019s response to oral iron treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jomb-2018-0052_s_007\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The research population consisted of 217 participants in total: 54 control, 53 ID, 58 non-ID anemia, and 52 IDA patients. A hemoglobin (Hb) value of &lt; 130.0 g\/L was defined as indicating anemia for men, while an Hb value of &lt; 120.0 g\/L was defined as indicating anemia for women. All patients were administered 270 mg oral elemental iron sulphate daily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jomb-2018-0052_s_008\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The RET-He was significantly lower in the IDA group, compared to other groups (IDA: 21.0 \u00b1 4.1, ID: 26.0 \u00b1 4.9, non-ID anemia: 32.1 \u00b1 6.8, control: 36.6 \u00b1 7.0; &lt; 0.001). The ID group had a lower RET-He compared to the non-ID anemia group and the control group. On the 5th day of treatment, the ID and IDA group showed no significant differences in terms of Hb while the RET-He level demonstrated a significant increase. The increase in the RET-He level observed in the IDA group on the 5th day was significantly higher compared to the increase observed in the ID group. A RET-He value of 25.4 pg and below predicted ID diagnosis with 90.4% sensitivity and 49.1% specificity in IDA patients, compared to the ID group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jomb-2018-0052_s_009\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of our study, therefore, suggest that RET-He may be a clinically useful marker in the diagnosis of ID and IDA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/jomb-2018-0052","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T06:30:51Z","timestamp":1548743451000},"page":"496-502","source":"Crossref","is-referenced-by-count":35,"title":["The importance of RET-He in the diagnosis of iron deficiency and iron deficiency anemia and the evaluation of response to oral iron therapy"],"prefix":"10.5937","volume":"38","author":[{"given":"Mehmet Ali","family":"U\u00e7ar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesude","family":"Falay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simten","family":"Da\u011fdas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Funda","family":"Ceran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin Merih","family":"Urlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcls\u00fcm","family":"\u00d6zet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref251","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1001\/jama.281.23.2225","article-title":"Reticulocyte hemoglobin content to diagnose iron deficiency in 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