{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:39:42Z","timestamp":1783431582918,"version":"3.54.6"},"reference-count":116,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"0","license":[{"start":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T00:00:00Z","timestamp":1562976000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,13]]},"abstract":"Summary<\/jats:title>\n\nBackground<\/jats:title>\nInsulin and its receptor (INSR<\/jats:italic>) have been implicated in the etiology of the polycystic ovarian syndrome (PCOS). Here, we investigate the association between INSR<\/jats:italic> rs1799817 polymorphism and PCOS in Saudi Arabian women.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nstudy group included 126 PCOS women and 118 normo-ovulatory matched controls. The demographic data was recorded, and the plasma levels of glucose, lipids, leptin, E2, LH, FSH, T, SHBG, and insulin were determined. The genotypic and allele frequencies of rs1799817 were evaluated in both PCOS and control group. Polymerase chain reaction (PCR) was used to amplify Exon 17 of the INSR<\/jats:italic> gene, and the amplified products were analyzed by direct sequencing. A single-nucleotide polymorphism (C to T) was found at locus 10923 (His1058) of rs1799817.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nIn the PCOS group, the mutant allele T occurs at a significantly higher frequency (0.306) compared to the control group (0.174) (p<0.001). It shows a dominant effect and elevates the relative risk of PCOS even in the heterozygotes (RR=2.82). After stratification of the participants by body mass index, the frequency of T allele was significantly higher in the lean patients with PCOS compared to the lean control. The obese PCOS also had a higher frequency than the obese control, but the difference was not statistically significant. Several parameter values were affected by the INSR<\/jats:italic> genotype, particularly W\/H ratio, lipid, insulin and glucose levels and insulin resistance in PCOS patients.<\/jats:p><\/jats:sec>\n\nConclusion<\/jats:title>\nThe INSR<\/jats:italic> gene polymorphism rs1799817 is a susceptibility locus associated with PCOS in Saudis and associated metabolic and hormonal changes, particularly, in the lean PCOS females.<\/jats:p>\n<\/jats:sec>","DOI":"10.2478\/jomb-2019-0023","type":"journal-article","created":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T09:31:41Z","timestamp":1563615101000},"source":"Crossref","is-referenced-by-count":5,"title":["Rs1799817 in INSR associates with susceptibility to polycystic ovary syndrome"],"prefix":"10.5937","volume":"0","author":[{"given":"Maha H.","family":"Daghestani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref321","first-page":"1","article-title":"Anthropometric and biochemical characteristics of polycystic ovarian syndrome in South Indian women using AES-2006 criteria","volume":"12","year":"2014","journal-title":"International Journal of Endocrinology and Metabolism"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Polycystic ovary syndrome","volume":"375","year":"2016","journal-title":"New England Journal of Medicine"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/obe.2007.0019","article-title":"Obesity and polycystic ovary syndrome","volume":"3","year":"2007","journal-title":"Obesity Management"},{"key":"ref781","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF02267063","article-title":"SSCP analysis of the tyrosine kinase 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Reproduction"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10815-009-9308-8","article-title":"Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome","volume":"26","year":"2009","journal-title":"Journal of Assisted Reproduction and Genetics"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","article-title":"Genomewide association study identifies eight new risk loci for polycystic ovary syndrome","volume":"44","year":"2012","journal-title":"Nature Genetics"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/132908","article-title":"Serum leptin levels in polycystic ovary syndrome and its relationship with metabolic and hormonal profile in Pakistani females","volume":"2014","year":"2014","journal-title":"International Journal of Endocrinology"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1477-7827-9-76","article-title":"Family association study between INSR gene polymorphisms and PCOS in Han Chinese","volume":"9","year":"2011","journal-title":"Reproductive Biology and Endocrinology"},{"key":"ref1061","first-page":"95","article-title":"The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS)","volume":"57","year":"2011","journal-title":"Clinical Laboratory"},{"key":"ref1091","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/MED.0b013e3282f1cfdc","article-title":"Leptin in reproduction","volume":"14","year":"2007","journal-title":"Current Opinion in Endocrinology, Diabetes and Obesity"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","article-title":"Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16. 3, 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gicum"},{"key":"ref851","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","year":"2010","journal-title":"BMC Medicine"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/humrep\/dew329","article-title":"Overweight and obese but not normal weight women with PCOS are at increased risk of Type 2 diabetes mellitus\u201a \u00c4\u00eea prospective, population-based cohort study","volume":"32","year":"2017","journal-title":"Human Reproduction"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"263","DOI":"10.29252\/ijrm.14.4.263","article-title":"Insulin resistance and endocrine-metabolic abnormalities in polycystic ovarian syndrome: Comparison between obese and non-obese PCOS patients","volume":"14","year":"2016","journal-title":"International Journal of Reproductive Bio-Medicine"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nrg2707","article-title":"Kinase mutations in human disease: interpreting genotype\u201a \u00c4\u00ecphenotype relationships","volume":"11","year":"2010","journal-title":"Nature Reviews Gene tics"},{"key":"ref561","first-page":"491","article-title":"Polycystic ovary syndrome: association of a C\/T single nucleotide polymorphism at tyrosine kinase domain of insulin receptor gene with pathogenesis among lean Japanese women","volume":"58","year":"2013","journal-title":"The Journal of Reproductive Medicine"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women\u201a health aspects of polycystic ovary syndrome (PCOS): the Amster dam ESHRE\/ASRM-Sponsored 3rd PCOS Con sensus Work shop Group","volume":"97","year":"2012","journal-title":"Fertility and 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