{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:49:05Z","timestamp":1782524945732,"version":"3.54.5"},"reference-count":100,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"0","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,31]]},"abstract":"<jats:title>Summary<\/jats:title>\n<jats:sec id=\"j_jomb-2019-0025_s_006\">\n<jats:title>Background<\/jats:title>\n<jats:p>This study aimed to investigate the association between <jats:italic>NLRP3<\/jats:italic> rs35829419 and <jats:italic>CARD8<\/jats:italic> rs2043211 polymorphisms and the risk of developing pleural plaques, asbestosis, and malignant mesothelioma (MM), and to study the influence of the interactions between polymorphisms and asbestos exposure on the risk of developing these diseases.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"j_jomb-2019-0025_s_007\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The case-control study included 416 subjects with pleural plaques, 160 patients with asbestosis, 154 subjects with MM and 149 subjects with no asbestos disease. The <jats:italic>NLRP3<\/jats:italic> rs35829419 and <jats:italic>CARD8<\/jats:italic> rs2043211 polymorphisms were determined using real-time PCR-based methods. In the statistical analysis, standard descriptive statistics was followed by univariate and multivariate logistic regression modelling.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"j_jomb-2019-0025_s_008\">\n<jats:title>Results<\/jats:title>\n<jats:p>Asbestos exposure (medium and high vs low) was associated with the risk for each studied asbestos-related disease. An increased risk of pleural plaques was found for <jats:italic>CARD8<\/jats:italic> rs2043211 AT + TT genotypes (OR = 1.48, 95% CI 1.01\u20132.16, p = 0.042). When the analysis was performed for MM patients as cases, and pleural plaques patients as controls, a decreased MM risk was observed for carriers of <jats:italic>CARD8<\/jats:italic> rs2043211 TT genotype (OR = 0.52, 95% CI 0.27\u20131.00, p = 0.049). The interactions between <jats:italic>NLRP3<\/jats:italic> rs35829419 and <jats:italic>CARD8<\/jats:italic> rs2043211 genotypes did not influence the risk of any asbestos-related disease. However, when testing interactions with asbestos exposure, a decreased risk of asbestosis was found for <jats:italic>NLRP3<\/jats:italic> CA+AA genotypes (OR = 0.09, 95% CI 0.01\u20130.60, p = 0.014).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"j_jomb-2019-0025_s_009\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The results of our study suggest that <jats:italic>NLRP3<\/jats:italic> and <jats:italic>CARD8<\/jats:italic> polymorphisms could affect the risk of asbestos-related diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2478\/jomb-2019-0025","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T09:30:32Z","timestamp":1559640632000},"source":"Crossref","is-referenced-by-count":5,"title":["NLRP3 and CARD8 polymorphisms influence risk for asbestos-related 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