{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:21:52Z","timestamp":1792106512419,"version":"4.4.0"},"reference-count":72,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"0","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,25]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec id=\"j_jomb-2019-0036_s_005\"><jats:title>Background<\/jats:title><jats:p>In this study, we aimed at determining the dynamic thiol\/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2019-0036_s_006\"><jats:title>Methods<\/jats:title><jats:p>55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol\/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2019-0036_s_007\"><jats:title>Results<\/jats:title><jats:p>In our study, it was found that the disulfide, disulfide\/native thiol, disulfide\/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide\/native thiol and disulfide\/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated.<\/jats:p><\/jats:sec><jats:sec id=\"j_jomb-2019-0036_s_008\"><jats:title>Conclusions<\/jats:title><jats:p>Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study.<\/jats:p><\/jats:sec>","DOI":"10.2478\/jomb-2019-0036","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T09:30:37Z","timestamp":1566725437000},"source":"Crossref","is-referenced-by-count":4,"title":["Dynamic thiol\/disulfide homeostasis and oxidant status in patients with hypoparathyroidism"],"prefix":"10.5937","volume":"0","author":[{"given":"Arzu 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