{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:53Z","timestamp":1787025293102,"version":"build-2736575974"},"reference-count":42,"publisher":"Centre for Evaluation in Education and Science (CEON\/CEES)","issue":"0","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,25]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Albuminuria is the standard biomarker for the diagnosis of diabetic nephropathy (DN). However, some patients with persistent microalbuminuria still progress to chronic kidney disease, raising the question of finding a better biomarker. This study aimed to evaluate the correlation of urinary liver-type fatty acid-binding protein (L-FABP) levels with renal function and to compare the role of urinary albumin-to-creatinine ratio (ACR) with urinary L-FABP in early detection of DN in type 2 diabetic patients.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The cross-sectional study was done on 106 type 2 diabetic patients and 30 non-diabetic people. L-FABP was measured with the Latex enhanced immunoturbidimetric technique.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There was a strong and negative correlation between the urine L-FABP levels and eGFR (r = -0.606, p<0.001). The urinary L-FABP levels were significantly higher (p<0.001) in the normoalbuminuria diabetic group than the non-diabetic control group. The ROC-curve analyses in the diabetic patients and the normoalbuminuria diabetic patients showed that the AUCL-FABP was remarkably higher (p<0.001) than the AUCACR. An optimal cutoff value of 5 mg L-FABP\/g Cr (with the sensitivity of 98.1% and specificity of 90%) and of 4.3 mg L-FABP\/g Cr (with the sensitivity of 100% and specificity of 86.67%) was set to detect DN in the diabetic patients and the normoalbuminuria diabetic patients, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The change in urinary L-FABP levels happened earlier than in urinary albumin during renal function impairment. Urinary L-FABP can be used as a better indicator than ACR for early detection of DN in type 2 diabetes.<\/jats:p>\n <\/jats:sec>","DOI":"10.2478\/jomb-2019-0037","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T05:30:43Z","timestamp":1566711043000},"source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of urinary L-FABP as an early marker for diabetic nephropathy in type 2 diabetic patients"],"prefix":"10.5937","volume":"0","author":[{"given":"Duong Thi Thuy","family":"Ngan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Gia","family":"Binh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Thi Huong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuc Thi Thu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phung Thanh","family":"Huong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3964","reference":[{"key":"ref271","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3346\/jkms.2013.28.1.100","article-title":"The role of urinary liver-type fatty acid-binding protein in critically ill patients","volume":"28","year":"2013","journal-title":"Journal of Korean Medical Science"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0002-9440(10)63384-6","article-title":"Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules","volume":"165","year":"2004","journal-title":"The American Journal of Pathology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2362.2011.02620.x","article-title":"Urinary liver-type fatty acid-binding protein level as a predictive biomarker of contrast-induced acute kidney injury","volume":"42","year":"2012","journal-title":"European Journal of Clinical Investigation"},{"key":"ref91","article-title":"Assessment of Urinary Liver-Type Fatty Acid Binding Protein (LFABP) Levels in Type 2 Diabetes Mellitus Patients with Nephropathy","volume":"13","year":"2019","journal-title":"Journal of Clinical & Diagnostic Research"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.2337\/dc12-1868","article-title":"Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"R1009","DOI":"10.1152\/ajpregu.00809.2010","article-title":"The proximal tubule in the pathophysiology of the diabetic kidney. American journal of physiology. Regulatory","volume":"300","year":"2011","journal-title":"Integrative and Comparative Physiology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ejim.2008.12.012","article-title":"The role of tubular injury in diabetic nephropathy","volume":"20","year":"2009","journal-title":"European Journal of Internal Medicine"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.2337\/diacare.28.8.2038","article-title":"Clinical Significance of Urinary Liver-Type Fatty Acid\u2013Binding Protein in Patients With Diabetic Nephropathy","volume":"28","year":"2005","journal-title":"Diabetes Care"},{"key":"ref261","first-page":"95","article-title":"Urinary L-FABP and its combination with urinary NGAL in early diagnosis of acute kidney injury after cardiac surgery in adult patients","volume":"18","year":"2013","journal-title":"Bio-markers: biochemical indicators of exposure, response, and susceptibility to chemicals"},{"key":"ref361","first-page":"164","article-title":"Relationship between hematological parameters and glycemic control in type 2 diabetes mellitus patients","volume":"28","year":"2019","journal-title":"J Med Biochem"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2362.2011.02620.x","article-title":"Urinary liver-type fatty acid-binding protein level as a predictive biomarker of contrast-induced acute kidney injury","volume":"42","year":"2012","journal-title":"European Journal of Clinical Investigation"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2478\/jomb-2018-0023","article-title":"Association of FTO gene variant (rs8050136) with type 2 diabetes and markers of obesity, glycaemic control and inflammation","volume":"38","year":"2019","journal-title":"J Med Biochem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/ki.2014.98","article-title":"\u2018 Progressive diabetic nephropathy. How useful is microalbuminuria?: contra\u2019","volume":"86","year":"2014","journal-title":"Kidney International"},{"key":"ref51","first-page":"95","article-title":"Urinary L-FABP and its combination with urinary NGAL in early diagnosis of acute kidney injury after cardiac surgery in adult patients","volume":"18","year":"2013","journal-title":"Bio-markers: biochemical indicators of exposure, response, and susceptibility to chemicals"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0002-9440(10)63384-6","article-title":"Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules","volume":"165","year":"2004","journal-title":"The American Journal of Pathology"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.legalmed.2012.11.001","article-title":"Diagnostic implications of urinary liver-type fatty acid-binding protein and 8-hydroxy-2\u2019-deoxyguanosine in forensic autopsy cases","volume":"15","year":"2013","journal-title":"Legal Medicine (Tokyo, Japan)"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-physiol-020911-153333","article-title":"Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney","volume":"74","year":"2012","journal-title":"Annual Review of Physiology"},{"key":"ref151","first-page":"164","article-title":"Relationship between hematological parameters and glycemic control in type 2 diabetes mellitus patients","volume":"28","year":"2019","journal-title":"J Med Biochem"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4236\/jbise.2013.65A005","article-title":"Absence of albuminuria in type 2 diabetics with classical diabetic nephropathy: clinical pathological study","volume":"6","year":"2013","journal-title":"Journal of Biomedical Science and Engineering"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11010-005-9047-9","article-title":"Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease","volume":"284","year":"2006","journal-title":"Molecular and Cellular Biochemistry"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.ackd.2017.10.011","article-title":"The Global Epidemiology of Diabetes and Kidney Disease","volume":"25","year":"2018","journal-title":"Advances in Chronic Kidney Disease"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.2337\/dc12-1868","article-title":"Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes","volume":"36","year":"2013","journal-title":"Diabetes Care"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cca.2013.05.020","article-title":"Urinary liver type fatty acid binding protein in diabetic nephropathy","volume":"424","year":"2013","journal-title":"Clinica chimica acta; international Journal of Clinical Chemistry"},{"key":"ref11","first-page":"49","article-title":"Diabetic kidney disease: world wide difference of prevalence and risk factors","volume":"5","year":"2015","journal-title":"Journal of Nephropharmacology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3390\/jcm4061207","article-title":"The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years","volume":"4","year":"2015","journal-title":"Journal of Clinical Medicine"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2478\/jomb-2018-0023","article-title":"Association of FTO gene variant (rs8050136) with type 2 diabetes and markers of obesity, glycaemic control and inflammation","volume":"38","year":"2019","journal-title":"J Med Biochem"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.2337\/diacare.28.8.2038","article-title":"Clinical Significance of Urinary Liver-Type Fatty Acid\u2013Binding Protein in Patients With Diabetic Nephropathy","volume":"28","year":"2005","journal-title":"Diabetes Care"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/ki.2014.98","article-title":"\u2018 Progressive diabetic nephropathy. How useful is microalbuminuria?: contra\u2019","volume":"86","year":"2014","journal-title":"Kidney International"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"R1009","DOI":"10.1152\/ajpregu.00809.2010","article-title":"The proximal tubule in the pathophysiology of the diabetic kidney. American journal of physiology. Regulatory","volume":"300","year":"2011","journal-title":"Integrative and Comparative Physiology"},{"key":"ref301","article-title":"Assessment of Urinary Liver-Type Fatty Acid Binding Protein (LFABP) Levels in Type 2 Diabetes Mellitus Patients with Nephropathy","volume":"13","year":"2019","journal-title":"Journal of Clinical & Diagnostic Research"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.legalmed.2012.11.001","article-title":"Diagnostic implications of urinary liver-type fatty acid-binding protein and 8-hydroxy-2\u2019-deoxyguanosine in forensic autopsy cases","volume":"15","year":"2013","journal-title":"Legal Medicine (Tokyo, Japan)"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3390\/jcm4061207","article-title":"The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years","volume":"4","year":"2015","journal-title":"Journal of Clinical Medicine"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4236\/jbise.2013.65A005","article-title":"Absence of albuminuria in type 2 diabetics with classical diabetic nephropathy: clinical pathological study","volume":"6","year":"2013","journal-title":"Journal of Biomedical Science and Engineering"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1053\/j.ackd.2017.10.011","article-title":"The Global Epidemiology of Diabetes and Kidney Disease","volume":"25","year":"2018","journal-title":"Advances in Chronic Kidney Disease"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ejim.2008.12.012","article-title":"The role of tubular injury in diabetic nephropathy","volume":"20","year":"2009","journal-title":"European Journal of Internal Medicine"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2337\/dc10-1392","article-title":"Clinical significance of urinary liver-type fatty acid-binding protein in diabetic nephropathy of type 2 diabetic patients","volume":"34","year":"2011","journal-title":"Diabetes Care"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cca.2013.05.020","article-title":"Urinary liver type fatty acid binding protein in diabetic nephropathy","volume":"424","year":"2013","journal-title":"Clinica chimica acta; international Journal of Clinical Chemistry"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev-physiol-020911-153333","article-title":"Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney","volume":"74","year":"2012","journal-title":"Annual Review of Physiology"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11010-005-9047-9","article-title":"Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease","volume":"284","year":"2006","journal-title":"Molecular and Cellular Biochemistry"},{"key":"ref221","first-page":"49","article-title":"Diabetic kidney disease: world wide difference of prevalence and risk factors","volume":"5","year":"2015","journal-title":"Journal of Nephropharmacology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3346\/jkms.2013.28.1.100","article-title":"The role of urinary liver-type fatty acid-binding protein in critically ill patients","volume":"28","year":"2013","journal-title":"Journal of Korean Medical Science"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2337\/dc10-1392","article-title":"Clinical significance of urinary liver-type fatty acid-binding protein in diabetic nephropathy of type 2 diabetic patients","volume":"34","year":"2011","journal-title":"Diabetes Care"}],"container-title":["Journal of Medical Biochemistry"],"original-title":[],"link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/jomb\/ahead-of-print\/article-10.2478-jomb-2019-0037.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scindeks-clanci.ceon.rs\/data\/pdf\/1452-8258\/2020\/1452-82582002224T.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T15:22:21Z","timestamp":1588864941000},"score":1,"resource":{"primary":{"URL":"https:\/\/scindeks.ceon.rs\/article.aspx?artid=1452-82582002224T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,25]]},"references-count":42,"journal-issue":{"issue":"0"},"URL":"https:\/\/doi.org\/10.2478\/jomb-2019-0037","relation":{},"ISSN":["1452-8266"],"issn-type":[{"value":"1452-8266","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,25]]}}}