{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:25Z","timestamp":1790957665875,"version":"4.1.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jtim-2019-0004_s_006_w2aab3b7b4b1b6b1aab1c17b1Aa\">\n                  <jats:title id=\"d13481648e7400_w2aab3b7b4b1b6b1aab1c17b1aAa\">Background and Objective<\/jats:title>\n                  <jats:p>Hepcidin is the key regulator of iron metabolism and is a significant biomarker for systemic inflammatory states. Vitamin D is a powerful immunomodulator and plays a significant role in the inflammatory responses and fibrosis occurring due to hepatitis C virus (HCV) infection. This study assessed the level of vitamin D and serum hepcidin and its expression in peripheral blood of children with chronic hepatitis C (CHC) and correlated them with other serum markers to reflect iron metabolism and liver disease severity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2019-0004_s_007_w2aab3b7b4b1b6b1aab1c17b2Aa\">\n                  <jats:title id=\"d13481648e7408_w2aab3b7b4b1b6b1aab1c17b2aAa\">Methods<\/jats:title>\n                  <jats:p>A total of 100 children were included in this study: 50 with HCV infection and 50 healthy controls. Biochemical parameters together with vitamin D, hepcidin, and its expression were all measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2019-0004_s_008_w2aab3b7b4b1b6b1aab1c17b3Aa\">\n                  <jats:title id=\"d13481648e7416_w2aab3b7b4b1b6b1aab1c17b3aAa\">Results<\/jats:title>\n                  <jats:p>The level of hepcidin and its expression together with vitamin D and hepcidin-to-ferritin (H\/F) ratios were significantly reduced in patients, but the iron and ferritin levels were higher (<jats:italic>P<\/jats:italic>&lt;0.001). Serum hepcidin level showed significant positive correlation with hepcidin expression, HCV titer, iron, ferritin, and H\/F ratio (<jats:italic>r<\/jats:italic> = 0.43, 0.31, 0.34, 0.28, and 0.91, respectively) but significant negative correlation with vitamin D (<jats:italic>r<\/jats:italic> = \u22120.37). Both hepcidin and ferritin were higher in patients with Child Pugh scores B and C than those with score A (<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2019-0004_s_009_w2aab3b7b4b1b6b1aab1c17b4Aa\">\n                  <jats:title id=\"d13481648e7436_w2aab3b7b4b1b6b1aab1c17b4aAa\">Conclusion<\/jats:title>\n                  <jats:p>Measuring serum hepcidin and its expression together with vitamin D levels in patients may have a prognostic value and is promising in the follow-up of the severity of liver disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jtim-2019-0004","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T09:30:11Z","timestamp":1555147811000},"page":"15-21","source":"Crossref","is-referenced-by-count":11,"title":["Importance of studying the levels of hepcidin and vitamin D in Egyptian children with chronic hepatitis C"],"prefix":"10.2478","volume":"7","author":[{"given":"Amal Ahmed","family":"Mohamed","sequence":"first","affiliation":[{"name":"Biochemistry and Molecular Biology, Biochemistry Department, National Hepatology and Tropical Centre , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman R.","family":"Abd Almonaem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Benha University , Benha , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira I.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University , Benha , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HebatAllah Fadel","family":"Algebaly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric and Pediatric Intensive Care, Cairo University School of Medicine , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Abdelmonem","family":"Khattab","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine S.","family":"El Abd","sequence":"additional","affiliation":[{"name":"Department of Microbial Biotechnology, Genetic Engineering and Biotechnology Division, National Research Centre , Cairo , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"2023042508120023903_j_jtim-2019-0004_ref_001_w2aab3b7b4b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Anderson G, Frazer D. 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