{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:59:21Z","timestamp":1785794361016,"version":"3.56.0"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_jtim-2020-0005_s_005_w2aab3b7c12b1b6b1aab1c15b1Aa\">\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Nonalcoholic steatohepatitis (NASH) is strongly associated with obesity. A weight loss of \u226510% is necessary to improve NASH severity, but this goal has rarely been achieved in published studies using different diet protocols. The effect of a ketogenic, hypocaloric, commercial diet (\u201cIdeal Protein,\u201d IP) on body weight, metabolic markers, and liver tests in a group of NASH patients is evaluated in this study. Daily calorie intake was tailored to achieve a weight loss of \u226510%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jtim-2020-0005_s_006_w2aab3b7c12b1b6b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 38 patients with NASH who were placed on the IP diet between 2014 and 2018 and compared their outcomes with 6 control patients who declined the diet. All patients were evaluated by a trained health coach in weekly intervals throughout the study period. Clinical and laboratory data obtained before and at 6.5 months after intervention were compared using paired t-testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jtim-2020-0005_s_007_w2aab3b7c12b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patients on the IP diet experienced a significant weight reduction (217 \u00b1 8 lb\n                      <jats:italic>vs<\/jats:italic>\n                      . 194 \u00b1 7 lb; mean \u00b1 S.E.M.), corresponding to an average weight loss of 9.7% \u00b1 1.6%. Significant changes in systolic blood pressure (133 \u00b1 3 mmHg\n                      <jats:italic>vs<\/jats:italic>\n                      . 123 \u00b1 3 mmHg), triglycerides (200 \u00b1 21 mmol\/L\n                      <jats:italic>vs<\/jats:italic>\n                      . 132 \u00b1 11 mmol\/L), hemoglobin A1c (6.71% \u00b1 0.29%\n                      <jats:italic>vs<\/jats:italic>\n                      . 5.74% \u00b1 0.19%), SGPT (97.3 \u00b1 11.1 IU\/L\n                      <jats:italic>vs<\/jats:italic>\n                      . 44.2 \u00b1 5.9 IU\/L), SGOT (82.4 \u00b1 10.5 IU\/L\n                      <jats:italic>vs<\/jats:italic>\n                      . 32.8 \u00b1 5.2 IU\/L), and Fib-4 scores (2.25 \u00b1 0.23\n                      <jats:italic>vs<\/jats:italic>\n                      . 1.40 \u00b1 0.13) were also observed (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05 in all cases). In the IP group, 50.5% of patients lost \u226510% body weight. In contrast, no significant changes were observed in the control group. The IP diet was well tolerated, and no safety signals were noticed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_jtim-2020-0005_s_008_w2aab3b7c12b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A ketogenic, hypocaloric resulted in striking weight loss and significant improvements in metabolic parameters and liver tests, suggesting that this approach carries promise for the dietary management of patients with NASH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/jtim-2020-0005","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T11:51:56Z","timestamp":1590493916000},"page":"26-31","source":"Crossref","is-referenced-by-count":20,"title":["Ketogenic, hypocaloric diet improves nonalcoholic steatohepatitis"],"prefix":"10.2478","volume":"8","author":[{"given":"Yuliya","family":"Belopolsky","sequence":"first","affiliation":[{"name":"Division of Internal Medicine, NorthShore University HealthSystem , Evanston, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Q.","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, NorthShore University HealthSystem , Evanston, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Portland VA Medical Center and Oregon Health & Science University , Portland, Oregon , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NorthShore University HealthSystem , Evanston, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus J.","family":"Fimmel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, NorthShore University HealthSystem , Evanston, Illinois , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"2026011619062596479_j_jtim-2020-0005_ref_001_w2aab3b7c12b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Neuschwander-Tetri BA. 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