{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:57:00Z","timestamp":1785902220431,"version":"3.56.0"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_jtim-2022-0044_s_010\">\n                  <jats:title>Background and Objectives<\/jats:title>\n                  <jats:p>Transcutaneous point-of-care ultrasound (POCUS) is a good tool to monitor the trachea in many clinical practices. The aim of our study is to verify the feasibility of POCUS-guided submucosal injection as a potential drug delivery method for the treatment of tracheal stenosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2022-0044_s_011\">\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>The inner wall of the trachea was monitored <jats:italic>via<\/jats:italic> a bronchoscope during the POCUS-guided submucosal injection of methylene blue in fresh <jats:italic>ex vivo<\/jats:italic> porcine trachea to evaluate the distribution of methylene blue. The feasibility and eficacy of POCUS-guided submucosal injection were evaluated in a tracheal stenosis rabbit model. Animals were divided into sham group, tracheal stenosis group, and treatment group. Ten days after the scraping of the tracheal mucosa or sham operation, POCUS-guided submucosal injection of paclitaxel or saline was performed. Seven days after the submucosal injection, the trachea was assessed by cervical computed tomography (CT) scan and ultrasound.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2022-0044_s_012\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The distribution of methylene blue in trachea proved the technical feasibility of POCUS-guided submucosal injection. CT evaluation revealed that the tracheal stenosis index and the degree of tracheal stenosis increased significantly in the stenosis group, while POCUS-guided submucosal injection of paclitaxel partially reversed the tracheal stenosis. POCUS-guided submucosal injection of paclitaxel also decreased the lamina propria thickness and collagen deposition in the stenosed trachea.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_jtim-2022-0044_s_013\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>POCUS-guided submucosal paclitaxel injection alleviated tracheal stenosis induced by scraping of the tracheal mucosa. POCUS-guided submucosal injection might be a potential method for the treatment of tracheal stenosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/jtim-2022-0044","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T13:21:59Z","timestamp":1683379319000},"page":"70-80","source":"Crossref","is-referenced-by-count":9,"title":["Point-of-care ultrasound-guided submucosal paclitaxel injection in tracheal stenosis model"],"prefix":"10.2478","volume":"11","author":[{"given":"Mingming","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengchan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Hospital of China Medical University , Shenyang , Liaoning Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, First Hospital of China Medical University , Shenyang , Liaoning Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, First Hospital of China Medical University , Shenyang , Liaoning Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Fourth Hospital of China Medical University , Shenyang , Liaoning Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,5,7]]},"reference":[{"key":"2024070515523111570_j_jtim-2022-0044_ref_001","doi-asserted-by":"crossref","unstructured":"Ulusan A, Sanli M, Isik A, Celik \u0130, Tuncozgur B, Elbeyli L. 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