{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:14:41Z","timestamp":1790694881186,"version":"4.1.0"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thrombolysis is not currently recommended in cirrhotic patients with acute portal vein thrombosis (PVT) in most guidelines, because of the exceedingly limited data and the perceived high risk of bleeding adverse events. However, in the few studies including patients with cirrhosis, the rate of success was high and that of adverse events was similar in patients with or without cirrhosis. Hence, thrombolysis might be a rescue therapeutic option in patients with cirrhosis and acute, symptomatic thrombosis of the portal venous system, unresponsive to anticoagulation, provided a suitable timing is kept, less than 30 days and, if possible, less than 14 days from the acute onset of portal vein thrombosis. In this review perspective article, I discuss the several potential approaches of thrombolysis, either local or systemic, alone or combined with mechanical procedures for thrombus removal, or as a complement to Transjugular Intrahepatic Portosystemic Shunt placement, with a focus on the more suitable timing of thrombolysis. However, the very limited available data preclude from performing firm recommendations, and decision to carry out thrombolysis must take into account both the occurrence of major contraindications and the current critical clinical setting. In the next future, large high-quality multicentre studies will hopefully be able to settle more firm indications and preferable techniques.<\/jats:p>","DOI":"10.2478\/jtim-2023-0113","type":"journal-article","created":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T15:52:02Z","timestamp":1693669922000},"page":"198-202","source":"Crossref","is-referenced-by-count":8,"title":["Approach to different thrombolysis techniques and timing of thrombolysis in the management of portal vein thrombosis in cirrhotic patients"],"prefix":"10.2478","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1588-2643","authenticated-orcid":false,"given":"Massimo","family":"Primignani","sequence":"first","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Tosetti","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Ierardi","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano , Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,2]]},"reference":[{"key":"2023090412302544595_j_jtim-2023-0113_ref_001","doi-asserted-by":"crossref","unstructured":"Violi F, Corazza GR, Caldwell SH, Perticone F, Gatta A, Angelico M, et al. PRO-LIVER Collaborators. Portal vein thrombosis relevance on liver cirrhosis: Italian Venous Thrombotic Events Registry. Intern Emerg Med 2016;11:1059\u201366.","DOI":"10.1007\/s11739-016-1416-8"},{"key":"2023090412302544595_j_jtim-2023-0113_ref_002","doi-asserted-by":"crossref","unstructured":"Maruyama H, Okugawa H, Takahashi M, Yokosuka O. De novo portal vein thrombosis in virus-related cirrhosis: predictive factors and longterm outcomes. Am J Gastroenterol 2013;108:568\u201374.","DOI":"10.1038\/ajg.2012.452"},{"key":"2023090412302544595_j_jtim-2023-0113_ref_003","doi-asserted-by":"crossref","unstructured":"Nery F, Chevret S, Condat B, de Raucourt E, Boudaoud L, Rautou PE, et al. Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study. 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