{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:16:09Z","timestamp":1790403369787,"version":"4.1.0"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    <jats:italic>Coxiella<\/jats:italic>\n                    (\n                    <jats:italic>C<\/jats:italic>\n                    .)\n                    <jats:italic>burnetii<\/jats:italic>\n                    , the aetiological agent of Q fever, is able to modulate the macrophage\/T-lymphocyte axis in an infected organism and impair synthesis of monokines and lymphokines.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and Methods:<\/jats:bold>\n                    The purpose of this research was to determine the levels of the cytokines that play a key role in the response to\n                    <jats:italic>C. burnetii<\/jats:italic>\n                    antigens (IL-1\u03b2, IL-2, IL-6, IL-10, IFN-\u03b3 and TNF-\u03b1) in the serum of animals originating from an infected herd prior to vaccination (day 0) and at 1, 7, and 21 days afterwards.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The vaccination of animals did not affect the production of IL-6, IL-1\u03b2, or IL-2. The serum levels of these cytokines were too low to measure in most of the samples. The initial levels of TNF\u03b1, IFN\u03b3, and IL-10 were higher in seropositive than in seronegative animals, although significant differences between seropositive shedders and seropositive nonshedders appeared only in the levels of IFN\u03b3 and IL-10. Additionally, the course of the post-vaccination response concerning these two cytokines was different among seronegative nonshedders, seropositive nonshedders, and seropositive shedders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    It seems that analysis of the IFN\u03b3 and IL-10 concentrations in animal blood serum may have some practical value in an assessment of the health status of seropositive animals and post-vaccination response.\n                  <\/jats:p>","DOI":"10.2478\/jvetres-2018-0076","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T04:32:53Z","timestamp":1547008373000},"page":"469-476","source":"Crossref","is-referenced-by-count":6,"title":["Early cytokine response after vaccination with\n                    <i>Coxiella burnetii<\/i>\n                    phase I in an infected herd of dairy cattle"],"prefix":"10.2478","volume":"62","author":[{"given":"Joanna","family":"Ma\u0142aczewska","sequence":"first","affiliation":[{"name":"Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine , University of Warmia and Mazury in Olsztyn , 10-718 Olsztyn , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta","family":"Kaczorek-\u0141ukowska","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine , University of Warmia and Mazury in Olsztyn , 10-718 Olsztyn , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Szyma\u0144ska-Czerwi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Cattle and Sheep Diseases\/Laboratory of Serological Diagnosis, National Veterinary Research Institute , 24-100 Pulawy , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"R\u0119kawek","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine , University of Warmia and Mazury in Olsztyn , 10-718 Olsztyn , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"W\u00f3jcik","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine , University of Warmia and Mazury in Olsztyn , 10-718 Olsztyn , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Niemczuk","sequence":"additional","affiliation":[{"name":"Department of Cattle and Sheep Diseases\/Laboratory of Serological Diagnosis, National Veterinary Research Institute , 24-100 Pulawy , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej Krzysztof","family":"Siwicki","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Immunology, Faculty of Veterinary Medicine , University of Warmia and Mazury in Olsztyn , 10-718 Olsztyn , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"2026042819454467271_j_jvetres-2018-0076_ref_001_w2aab3b7c20b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. 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