{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:29:15Z","timestamp":1786613355986,"version":"build-2736575974"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Kisspeptin (KiSS), neurokinin B (NKB) and dynorphin A (Dyn A) participate in the neuroendocrine regulation of reproductive system development and functioning; however, their roles in the onset of sexual maturity and pathomechanism of delayed puberty have not yet been fully elucidated. The aim of the study was to determine changes in the kisspeptin-10 (KiSS-10), NKB and Dyn A concentration in blood plasma collected from ewe lambs during puberty in relation to the first ovulation time, and to examine the relationship between these neuropeptides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Twenty-four ewe lambs were divided into two groups: from single (S) pregnancies and from twin (T) pregnancies. To determine the KiSS-10, NKB and Dyn A concentration with ELISA, blood was collected from all sheep at 4, 5, 6, 7, 8, 9 and 10 months of age. Singletons and twins had their first ovulations at 8 and 10 months of age, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Changes in the KiSS-10 and NKB concentrations were positively correlated with age in both S (r = 0.86) and T ewes (r = 0.89). A negative correlation was found between KiSS-10 and Dyn A (r = \u20130.55 and \u20130.98, for S and T, respectively) and between NKB and Dyn A (r = \u20130.89 and \u20130.94, for S and T, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The initiation of ovarian activity is associated with concurrent increases in plasma KiSS-10 and NKB concentrations with age and reduced Dyn A concentrations in both groups. Our results show that these neuropeptides may regulate the timing of reproductive activity onset in sheep.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/jvetres-2026-0010","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T12:20:48Z","timestamp":1772454048000},"page":"139-147","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes"],"prefix":"10.2478","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-2500","authenticated-orcid":false,"given":"Natalia","family":"Szysiak","sequence":"first","affiliation":[{"name":"Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin , Lublin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-5103","authenticated-orcid":false,"given":"Urszula","family":"Kosior-Korzecka","sequence":"additional","affiliation":[{"name":"Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin , Lublin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-3815","authenticated-orcid":false,"given":"Monika","family":"Gregu\u0142a-Kania","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Agricultural Consulting, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin , Lublin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-8981","authenticated-orcid":false,"given":"Krzysztof","family":"Patkowski","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Agricultural Consulting, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin , Lublin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-2365","authenticated-orcid":false,"given":"Mateusz","family":"Fila","sequence":"additional","affiliation":[{"name":"Sub-Department of Pathophysiology, Department of Preclinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Life Sciences in Lublin , Lublin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2679-9597","authenticated-orcid":false,"given":"Andrzej","family":"Junkuszew","sequence":"additional","affiliation":[{"name":"Department of Animal Breeding and Agricultural Consulting, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin , Lublin , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2026081309003735093_j_jvetres-2026-0010_ref_001","doi-asserted-by":"crossref","unstructured":"Abadjieva D., Shumkov K., Kistanova E., Kacheva D., Georgiev B.: Opportunities for the improvement of the reproductive performances in female animals. 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