{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T04:22:42Z","timestamp":1679545362916},"reference-count":54,"publisher":"Polish Academy of Sciences Chancellery","issue":"1","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The overall objective of this study was to examine the effect of vaginal administration of prostaglandin E<jats:sub>2<\/jats:sub>(PGE<jats:sub>2<\/jats:sub>) and\/or17\u03b2-estradiol (E<jats:sub>2<\/jats:sub>) on luteal function maintenance and histological properties of the porcine cervix. For this purpose, crossbred gilts were divided into three groups (n=5 per group) supplied on days 11-16 of the estrous cycle with suppositories containing: (1) placebo (Group I, Control); (2) 0.4 mg of E<jats:sub>2<\/jats:sub>(Group II); (3) 0.4 mg of E<jats:sub>2<\/jats:sub>and 2 mg of PGE<jats:sub>2<\/jats:sub>(Group III). Blood samples were collected on days 11-19 of the estrous cycle to determine the concentration of progesterone (P<jats:sub>4<\/jats:sub>). Additionally, to examine local effects of the hormones applied, segments from the uterine and vaginal parts of the cervix and from the ovaries were collected post-mortem. Prolonged luteal function and extended synthesis of P<jats:sub>4<\/jats:sub>were observed in 2 of 5 gilts receiving PGE2 and E2 simultaneously (Group III). Then, these gilts were subdivided into Group IIIA (n=2; presence of corpora lutea on the ovaries) and Group IIIB (n=3; lack of corpora lutea). Increased levels of plasma P<jats:sub>4<\/jats:sub>were observed in Group IIIA on days 15-19 compared to Group IIIB and on days 16-19 compared to Group I and Group II (P&lt;0.05; P&lt;0.01; P&lt;0.001, respectively). In the cervix of gilts in Groups II and III, enlarged blood vessels in the lamina propria of both parts of the cervix were observed. Furthermore, in Group II the epithelium of the uterine part of the cervix was thicker (P&lt;0.001). Our study confirmed the proposed luteotrophic\/antiluteolytic actions of E<jats:sub>2<\/jats:sub>and PGE<jats:sub>2<\/jats:sub>applied intravaginally. These results are significant considering that very low doses of E<jats:sub>2<\/jats:sub>were used when compared to previous attempts. Despite the inadequate response to treatments in some of the gilts, the local effects of these hormones on the histological properties of the porcine cervix suggest that further improvements in the vaginal administration route might help to elaborate new methods for enhancing the luteal function in the pig.<\/jats:p>","DOI":"10.2478\/pjvs-2014-0016","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T15:14:47Z","timestamp":1409757287000},"page":"123-130","source":"Crossref","is-referenced-by-count":1,"title":["Effect of vaginal administration of prostaglandin E2 and\/or 17\u03b2-estradiol on luteal function and histological characteristics of the cervix in cyclic pigs"],"prefix":"10.24425","volume":"17","author":[{"given":"E.","family":"Przygrodzka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Andronowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Janowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Zi\u0119cik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","reference":[{"key":"ref91","first-page":"125","article-title":"Hormonal control of the cervix in pregnant gilts Changes in the physical properties of the cervix correlate temporally with elevated serum levels of estrogen and relaxin","author":"Eldridge","year":"1989","journal-title":"Endocrinology"},{"key":"ref401","first-page":"11","article-title":"Uterine blood flow and uterine arterial venous and luminal concentrations of oestrogens on days after oestrus in pregnant and non - pregnant sows","author":"Ford","year":"1982","journal-title":"J Reprod Fertil"},{"key":"ref431","first-page":"131","article-title":"Maternal recognition of pregnancy signal or endocrine disruptor : the two faces of oestrogen during establishment of pregnancy in the pig Fertil","author":"Geisert","year":"2006","journal-title":"Soc"},{"key":"ref191","first-page":"261","article-title":"Normal cyclical morphology of the endometrium and ovary of swine","volume":"16","author":"Leiser","year":"1988","journal-title":"Tierarztl Prax"},{"key":"ref491","first-page":"184","article-title":"Long Characterization of effects of zearalenone in swine during early pregnancy","author":"Diekman MA","year":"1986","journal-title":"Am J Vet Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2478\/pjvs-2013-0044","article-title":"The novel effect of hCG administration on luteal function maintenance during the estrous cycle \/ pregnancy and early embryo development in the pig","volume":"16","author":"Bo\u0142zan","year":"2013","journal-title":"Pol J Vet Sci"},{"key":"ref261","first-page":"194","article-title":"Differential expression of prostaglandin synthesis enzymes in conceptus during peri - implantation period and endometrial expression of carbonyl reductase ketoreductase in the pig","author":"Waclawik","year":"2007","journal-title":"J Endocrinol"},{"key":"ref151","first-page":"293","article-title":"Embryonic steroids and the establishment of pregnancy in pigs","author":"Geisert","year":"1990","journal-title":"J Reprod Fertil"},{"key":"ref51","first-page":"287","article-title":"The effect of intravaginal application of estradiol and progesterone on porcine embryo development","volume":"11","author":"Ch\u0142opek","year":"2008","journal-title":"Pol J Vet Sci"},{"key":"ref201","first-page":"184","article-title":"Long Characterization of effects of zearalenone in swine during early pregnancy","author":"Diekman MA","year":"1986","journal-title":"Am J Vet Res"},{"key":"ref381","first-page":"125","article-title":"Hormonal control of the cervix in pregnant gilts Changes in the physical properties of the cervix correlate temporally with elevated serum levels of estrogen and relaxin","author":"Eldridge","year":"1989","journal-title":"Endocrinology"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.prostaglandins.2006.07.004","article-title":"Retrograde and local destination transfer of uterine prostaglandin in early pregnant sow and its physiological consequences Other Lipid","volume":"81","author":"Stefanczyk","year":"2006","journal-title":"Prostaglandins"},{"key":"ref551","first-page":"194","article-title":"Differential expression of prostaglandin synthesis enzymes in conceptus during peri - implantation period and endometrial expression of carbonyl reductase ketoreductase in the pig","author":"Waclawik","year":"2007","journal-title":"J Endocrinol"},{"key":"ref531","first-page":"15","article-title":"The role of hormones in the relaxation of the uterine portion of the cervix in swine","volume":"19","author":"Smith","year":"1958","journal-title":"Am J Vet Res"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.2527\/jas1986.6341208x","article-title":"First NL Dose - response shift in the ability of gilts to remain pregnant following exogenous estradiol exposure","volume":"17","author":"Pope","year":"1986","journal-title":"J Anim Sci"},{"key":"ref441","first-page":"293","article-title":"Embryonic steroids and the establishment of pregnancy in pigs","author":"Geisert","year":"1990","journal-title":"J Reprod Fertil"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1095\/biolreprod21.3.617","article-title":"Blood flow to uteri of sows during the estrous cycle and early pregnancy : local effect of the conceptus on the uterine blood supply","volume":"21","author":"Ford","year":"1979","journal-title":"Biol Reprod"},{"key":"ref61","first-page":"87","article-title":"Direct luteotrophic effect of oestradiol \u03b2 on pig corpora lutea","volume":"17","author":"Conley","year":"1989","journal-title":"J Reprod Fertil"},{"key":"ref481","first-page":"261","article-title":"Normal cyclical morphology of the endometrium and ovary of swine","volume":"16","author":"Leiser","year":"1988","journal-title":"Tierarztl Prax"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0090-6980(86)90132-2","article-title":"Sparing effects of intrauterine treatment with prostaglandin on luteal function in cycling gilts","author":"Akinlosotu","year":"1986","journal-title":"Prostaglandins"},{"key":"ref111","first-page":"11","article-title":"Uterine blood flow and uterine arterial venous and luminal concentrations of oestrogens on days after oestrus in pregnant and non - 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and progesterone - induced estrogen receptor depletion and subsequent replenishment","author":"Rosser","year":"1993","journal-title":"Biol Reprod"},{"key":"ref181","first-page":"168","article-title":"The oestrous cycle and early pregnancy - a new concept of local endocrine regulation","author":"Krzymowski","year":"2004","journal-title":"Vet J"},{"key":"ref221","first-page":"39","article-title":"Effect of the suppository base on progesterone delivery from the vagina","author":"Price","year":"1983","journal-title":"Fertil Steril"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1530\/jrf.0.0790163","article-title":"Length of pseudopregnancy and pattern of uterine protein release as influenced by time and duration of oestrogen administration in the pig","author":"Geisert","year":"1987","journal-title":"J Reprod Fertil"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/BF03548217","article-title":"Einer Rapid absorption and local redistribution of progesterone after vaginal application in gilts","volume":"34","author":"Jensen","year":"1993","journal-title":"Acta Vet Scand"},{"key":"ref471","first-page":"168","article-title":"The oestrous cycle and early pregnancy - 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Morphological changes and infiltration of immune cells during oestrus and dioestrus in the sow","author":"Edstrom","year":"2009"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2527\/jas1982.553657x","article-title":"Orden Local and systemic effects of intrauterine estradiol beta on luteal function of nonpregnant sows","volume":"17","author":"Ford","year":"1982","journal-title":"J Anim Sci"}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/pjvs\/17\/1\/article-p123.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/view\/j\/pjvs.2014.17.issue-1\/pjvs-2014-0016\/pjvs-2014-0016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T14:03:32Z","timestamp":1679493812000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.pan.pl\/dlibra\/publication\/114190\/edition\/99244\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,1]]},"references-count":54,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2478\/pjvs-2014-0016","relation":{},"ISSN":["2300-2557"],"issn-type":[{"value":"2300-2557","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,1]]}}}