{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:24:28Z","timestamp":1783905868241,"version":"3.55.0"},"reference-count":32,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The development of spontaneous bacterial peritonitis (SBP) is a serious and life-threatening condition in patients with cirrhosis and ascites. The aim of this study was to determine the diagnostic potential of calprotectin in ascites, for SBP in patients with liver cirrhosis and ascites before and after antibiotic treatment and to compare the mean values of calprotectin in ascites in patients with and without SBP. This prospective-observational study was comprised of 70 patients with cirrhosis and ascites, divided into two groups, the SBP and the non-SBP group. Quantitative measurements of calprotectin in ascites was completed with the Quantum Blue Calprotectin Ascites test (LF-ASC25), using the Quantum Blue Reader. The average value of calprotectin in the SBP group was 1.5 \u00b1 0.40 \u03bcg \/ mL, and in the non-SBP group it was lower (0.4 \u00b1 0.30). The difference between the mean values was statistically significant with p &lt;0.05. The mean value of calprotectin in ascites before therapy among the SBP group was 1.5 \u00b1 0.4, and after antibiotic therapy, the value decreased significantly to 1.0 \u00b1 0.6; the difference between the mean values was statistically significant with p &lt;0.05. ROC analysis indicated that calprotectin contributed to the diagnosis of SBP with a 94.3% sensitivity rating (to correctly identify positives), and the specificity was 62.5%, which corresponded to the value of 0.275. Our research confirmed that ascitic calprotectin was a good predictor, and is significantly associated with the occurrence of SBP in patients with liver cirrhosis. By monitoring the value of calprotectin in ascites on the 7th day of antibiotic treatment, the effectiveness of antibiotic treatment in patients with SBP can be determined.<\/jats:p>","DOI":"10.2478\/prilozi-2021-0040","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T10:57:33Z","timestamp":1642244253000},"page":"97-106","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Potential of Calprotectin for Spontaneous Bacterial Peritonitis in Patients Withliver Cirrhosis and Ascites"],"prefix":"10.2478","volume":"42","author":[{"given":"Fana Lichoska","family":"Josifovikj","sequence":"first","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalina Grivcheva","family":"Stardelova","sequence":"additional","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beti","family":"Todorovska","sequence":"additional","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena Genadieva","family":"Dimitrova","sequence":"additional","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad","family":"Joksimovikj","sequence":"additional","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Andreevski","sequence":"additional","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meri","family":"Trajkovska","sequence":"additional","affiliation":[{"name":"University Clinical Centre Mother Teresa, Clinic for Gasteroenterohepatology, Faculty of Medicine , Ss. Cyril and Methodius University in Skopje , Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Serafimovski","sequence":"additional","affiliation":[{"name":"Macedonian Academy of Sciences and Arts Skopje R. North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"2026071211065948643_j_prilozi-2021-0040_ref_001","doi-asserted-by":"crossref","unstructured":"1. Rimola A, Garc\u00eda-Tsao G, Navasa M, Piddock LJ, Planas R, Bernard B, et al. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. JHepatol 2000; 32: 142\u201353.10.1016\/S0168-8278(00)80201-9","DOI":"10.1016\/S0168-8278(00)80201-9"},{"key":"2026071211065948643_j_prilozi-2021-0040_ref_002","doi-asserted-by":"crossref","unstructured":"2. European Association for the Study of the Liver. EASL clinical practice guidelines for the management of patients with decompensated cirrhosis. 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Acquired C3 deficiency in patients with alcoholic cirrhosis predisposes to infection and increased mortality. Gut 1997; 40: 544\u2013549.10.1136\/gut.40.4.54410271339176087","DOI":"10.1136\/gut.40.4.544"},{"key":"2026071211065948643_j_prilozi-2021-0040_ref_011","doi-asserted-by":"crossref","unstructured":"11. Homann C, Garred P, Graudal N, Hasselqvist Ph, Christiansen M, Fagerhol K.M, et al. Plasma calprotectin: a new prognostic marker of survival in alcohol-induced cirrhosis. Hepatology 1995; 21: 979\u2013985.10.1002\/hep.1840210415","DOI":"10.1002\/hep.1840210415"},{"key":"2026071211065948643_j_prilozi-2021-0040_ref_012","doi-asserted-by":"crossref","unstructured":"12. Homann C, Christensen E, Schlichting P, Philipsen EK, Graudal NA, Garred P. Ascites fluid and plasma calprotectin concentrations in liver disease. 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Cho JH, Park KH, Kim SH, Bang JH, Park WB, Kim HB, et al. Bacteremia is a prognostic factor for poor outcome in spontaneous bacterial peritonitis. Scand J Infect Dis 2007; 39: 697\u2013702.10.1080\/0036554070129958217654346","DOI":"10.1080\/00365540701299582"}],"container-title":["PRILOZI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/prilozi-2021-0040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:57:10Z","timestamp":1783904230000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/prilozi-2021-0040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,1]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,12,30]]},"published-print":{"date-parts":[[2021,12,31]]}},"alternative-id":["10.2478\/prilozi-2021-0040"],"URL":"https:\/\/doi.org\/10.2478\/prilozi-2021-0040","relation":{},"ISSN":["1857-8985"],"issn-type":[{"value":"1857-8985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,1]]}}}