{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:10:33Z","timestamp":1783901433522,"version":"3.55.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction<\/jats:bold>\n                    : Studies determined that age and associated comorbidities are associated with worse outcomes for COVID-19 patients. The aim of the present study is to examine previous electronic health records of SARS-CoV-2 patients to identify which chronic conditions are associated with in-hospital mortality in a nationally representative sample.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods<\/jats:bold>\n                    : The actual study is a cross-sectional analysis of SARS-CoV-2 infected patients who were treated in repurposed hospitals. The study includes a cohort of patients treated from 06-11-2020 to 15-03-2021 for COVID-19 associated pneumonia. To examine the presence of comorbidities, electronic health records were examined and analyzed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : A total of 1486 in-patients were treated in the specified period, out of which 1237 met the criteria for case. The median age of the sample was 65 years. The overall in-hospital mortality in the sample was 25.5%, while the median length of stay was 11 days. From whole sample, 16.0% of the patients did not have established diagnoses in their electronic records, while the most prevalent coexisting condition was arterial hypertension (62.7%), followed by diabetes mellitus (27.3%). The factors of age, male gender, and the number of diagnoses showed a statistically significant increase in odds ratio (OR) for in-hospital mortality. The presence of chronic kidney injury was associated with the highest increase of OR (by 3.37) for in-hospital mortality in our sample.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : The study reaffirms the findings that age, male gender, and the presence of comorbidities are associated with in-hospital mortality in COVID-19 treated and unvaccinated patients. Our study suggests that chronic kidney injury showed strongest association with the outcome, when adjusted for age, gender, and coexisting comorbidities.\n                  <\/jats:p>","DOI":"10.2478\/prilozi-2023-0044","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T14:48:18Z","timestamp":1702910898000},"page":"27-39","source":"Crossref","is-referenced-by-count":1,"title":["Comorbid Conditions in a Cohort of Inpatients with SARS-CoV-2 and their Association with In-Hospital Mortality During the Early Phases of the Pandemic"],"prefix":"10.2478","volume":"44","author":[{"given":"Dejan","family":"Dokic","sequence":"first","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"PHI University Clinic for Pulmonology and Allergology , Skopje , RN Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Cibrev","sequence":"additional","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"PHI University Clinic for Neurology , Skopje , RN Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Danilovski","sequence":"additional","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"Institute for Epidemiology, Biostatistics and Medical informatics , Skopje , RN Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Chamurovski","sequence":"additional","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"Institute for Tuberculosis and Respiratory Diseases , Skopje , RN 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Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"Klenkoski","sequence":"additional","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"PHI University Clinic for Eye Diseases , Skopje , RN Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdanka","family":"Arnautovska","sequence":"additional","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"PHI University Clinic for ORL , Skopje , RN Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Barbov","sequence":"additional","affiliation":[{"name":"Medical Faculty, Saints Cyril and Methodius University in Skopje , Skopje , RN Macedonia"},{"name":"PHI University Clinic for Neurology , Skopje , RN 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