{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T02:08:20Z","timestamp":1783908500431,"version":"3.55.0"},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Introduction<\/jats:bold>\n                    : Hypoxemia that occurs during one-lung ventilation (OLV) in thoracic surgery increases the risk of perioperative and postoperative complications, affecting mortality and morbidity. The aim of this study is to analyze the occurrence of perioperative hypoxemia (SpO\u2082 \u2264 90%) and to determine whether preoperative spirometry results and arterial blood gas analyses influence its development.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Materials and Methods<\/jats:bold>\n                    : In this retrospective study, we evaluated 80 elective patients who underwent lung resection (segmentectomy, lobectomy, bilobectomy, pneumonectomy) due to malignancy under one-lung ventilation. The patients had ASA I-III, EF &gt;50%, FEV\u2081 &gt;40%, and PaO\u2082 &gt;60 mmHg. We administered anesthesia in accordance with a standard protocol. We excluded patients under the age of 18, those with pathological arrhythmias, metastatic changes in the contralateral lung, endocrine disorders, renal or hepatic dysfunction, coagulation disorders, or those who had previously undergone radiotherapy or chemotherapy. We evaluated demographic, clinical, and surgical data, with a special focus on the results of preoperative spirometry and blood gas analyses and their correlation with the occurrence of desaturation (SpO2 \u2264 90%), which was measured every 10 minutes from the start of OLV.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Desaturation had the highest percentage of occurrences 20 minutes after the initiation of OLV (27.5%). It was more common in patients with right-sided surgery, patients with FEV\u2081% \u2265 70 and FVC%\u226570, and in overweight patients (BMI \u2265 25).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion<\/jats:bold>\n                    : The risk factors for hypoxemia during one-lung ventilation in thoracic surgery include right-sided surgery, which poses higher anatomical challenges for oxygenation, and pulmonary function values such as FEV and FVC at or above 70 percent. Additionally, a higher body mass index (BMI) is a key predictor of oxygen saturation drops. These factors highlight the need for careful preoperative assessment to manage oxygenation effectively.\n                  <\/jats:p>","DOI":"10.2478\/prilozi-2025-0028","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:41:41Z","timestamp":1765287701000},"page":"113-120","source":"Crossref","is-referenced-by-count":0,"title":["Factors Affecting the Occurrence of Hypoxemia During One-Lung Ventilation"],"prefix":"10.2478","volume":"46","author":[{"given":"Marija","family":"Jovanovski-Srceva","sequence":"first","affiliation":[{"name":"University Clinic for Traumatology, Orthopedic Diseases, Anesthesiology, Reanimation and Intensive Care Medicine and Emergency Department , Clinical Center \u201cMother Theresa\u201d Faculty of Medicine, \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kokareva","sequence":"additional","affiliation":[{"name":"University Clinic for Traumatology, Orthopedic Diseases, Anesthesiology, Reanimation and Intensive Care Medicine and Emergency Department , Clinical Center \u201cMother Theresa\u201d Faculty of Medicine, \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Brzanov-Gavrilovska","sequence":"additional","affiliation":[{"name":"University Clinic for Traumatology, Orthopedic Diseases, Anesthesiology, Reanimation and Intensive Care Medicine and Emergency Department , Clinical Center \u201cMother Theresa\u201d Faculty of Medicine, \u201cSs. Cyril and Methodius\u201d University , Skopje , Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"key":"2026071215563937809_j_prilozi-2025-0028_ref_001","doi-asserted-by":"crossref","unstructured":"Walsh AM., Lohser J. Arterial oxygenation and management of hypoxemia during VATS. Curr Anesthesiol Rep. 2014; 4: 170\u20136.","DOI":"10.1007\/s40140-014-0051-z"},{"key":"2026071215563937809_j_prilozi-2025-0028_ref_002","doi-asserted-by":"crossref","unstructured":"Lumb AB., Slinger P. Hypoxic pulmonary vasoconstriction: physiology and anesthetic implications. Anesthesiology. 2015 Apr; 122(4): 932\u201346.","DOI":"10.1097\/ALN.0000000000000569"},{"key":"2026071215563937809_j_prilozi-2025-0028_ref_003","doi-asserted-by":"crossref","unstructured":"Karzai W., Schwarzkopf K. Hypoxemia during one-lung ventilation. Prediction, prevention and treatment. Anesthesiology. 2009; 110: 1402\u201311.","DOI":"10.1097\/ALN.0b013e31819fb15d"},{"key":"2026071215563937809_j_prilozi-2025-0028_ref_004","doi-asserted-by":"crossref","unstructured":"Ishikawa S., Lohser J. One-lung ventilation and arterial oxygenation. Curr Opin Anesth. 2011; 24: 24\u201331.","DOI":"10.1097\/ACO.0b013e3283415659"},{"key":"2026071215563937809_j_prilozi-2025-0028_ref_005","doi-asserted-by":"crossref","unstructured":"Campos JH., Feider A. Hypoxia during one- lung ventilation\u2014 a review and update. J Cardiothor Vasc Anesth. 2018; 32(5): 2330\u20132338.","DOI":"10.1053\/j.jvca.2017.12.026"},{"key":"2026071215563937809_j_prilozi-2025-0028_ref_006","doi-asserted-by":"crossref","unstructured":"Bickler P., Feiner J., Lipnick S., et al. Effects of acute, profound hypoxia on healthy humans: Implications for safety of tests evaluating pulse oximetry or tissue oximetry performance. 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