{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:50:05Z","timestamp":1780530605868,"version":"3.54.1"},"reference-count":68,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p><jats:bold>Background.<\/jats:bold> The choice of endoscopic expanded endonasal approach introduces the possibility of improved gross total resection of craniopharyngioma while minimizing surgical morbidity in a significant subset of patients.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Methods. <\/jats:bold>From our trans-sphenoidal surgical series of 331 cases, we retrospectively reviewed visual, endocrine and neuro-cognitive outcomes in the first consecutive eight patients (median age 63 years; range 47-73 years) with newly diagnosed supradiaphragmatic craniopharyngioma (median tumour height 23 mm; range 15-34 mm), removed by expanded endonasal approach (median follow-up 27 months; range 10-69 months). Gross total resection was attempted in all patients.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Results.<\/jats:bold> Gross total resection was achieved in 6 of 8 patients. Visual improvement was present in 6 of 8 patients of patients or in 14 of 16 eyes. New endocrinopathy, including diabetes insipidus, appeared in 5 of 8 patients. Stalk was preserved in 4 patients. Cognitive decline was present in 2 cases. Five of 8 patients retained previous quality of life.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Conclusions.<\/jats:bold> Our early outcome results are comparable to the recent few expanded endonasal approach series, except for the incidence of new endocrinopathy and cerebrospinal fluid leak rate. This was influenced by higher number of transinfundibular tumours in our series, where stalk preservation is less likely, and not using nasoseptal flap or gasket closure in the first half of cases. Including data from the literature and ours, expanded endonasal approach shows a trend for improved gross total resection rate with less morbidity, more obviously for visual outcome and quality of life than for endocrine outcome. However, validity of expanded endonasal approach should be confirmed in a larger number of patients with a longer follow-up period.<\/jats:p>","DOI":"10.2478\/raon-2013-0036","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T14:01:43Z","timestamp":1371477703000},"page":"266-279","source":"Crossref","is-referenced-by-count":27,"title":["Early outcome in endoscopic extended endonasal approach for removal of supradiaphragmatic craniopharyngiomas: a case series and a comprehensive 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craniopharyngiomas report of patients","author":"Shi","year":"2006","journal-title":"Med Engl"},{"key":"ref181","first-page":"111","article-title":"Extended endoscopic endonasal transsphenoidal approach for residual or recurrent craniopharyngiomas","volume":"19","author":"Cavallo","year":"2009","journal-title":"J Neurosurg"},{"key":"ref151","first-page":"37","article-title":"Surgical management of craniopharyngiomas a","volume":"16","author":"Samii","year":"1997","journal-title":"review Neurol Med Chir"},{"key":"ref571","first-page":"144","article-title":"Total removal of craniopharyngiomas Approaches and long - term results in patients","volume":"17","author":"Yasargil","year":"1990","journal-title":"J Neurosurg"},{"key":"ref101","article-title":"Craniopharyngioma a comparison of tumor control with various treatment strategies","volume":"11","author":"Yang","year":"2010","journal-title":"Neurosurg Focus"},{"key":"ref431","first-page":"109","article-title":"Craniopharyngioma 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craniopharyngioma","author":"Tachibana","year":"2005"},{"key":"ref731","first-page":"168","article-title":"Surgical treatment of craniopharyngiomas experience with patients","author":"Fahlbusch","year":"1999","journal-title":"J Neurosurg"},{"key":"ref771","first-page":"37","article-title":"Outcome of endoscopy - assisted microscopic extended transsphenoidal surgery for suprasellar adult craniopharyngiomas Lausanne","author":"Ikeda","year":"2012","journal-title":"Front Endocrinol"},{"key":"ref621","first-page":"109","article-title":"AB CH AH Outcomes following endoscopic expanded endonasal resection of suprasellar craniopharyngiomas : a case series","volume":"22","author":"Gardner","year":"2008","journal-title":"J Neurosurg"},{"key":"ref201","first-page":"59","article-title":"The endoscopic extended transsphenoidal approach for craniopharyngiomas 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craniopharyngioma","author":"Chakrabarti","year":"2005","journal-title":"J Neurosurg"},{"key":"ref331","first-page":"284","article-title":"treatment of craniopharyngiomas report of patients","author":"Shi","year":"2006","journal-title":"Med Engl"},{"key":"ref241","first-page":"44","article-title":"AB Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap discussion","volume":"25","author":"Kassam","year":"2008","journal-title":"Neurosurgery"},{"key":"ref261","first-page":"1","article-title":"Membranous layers of the pituitary gland : histological anatomic study and related clinical issues discussion","volume":"9","author":"Songtao","year":"2009","journal-title":"Neurosurgery"},{"key":"ref461","first-page":"58","article-title":"Steno Tumor - third ventricular relationships in supradiaphragmatic craniopharyngiomas : correlation of morphological magnetic resonance imaging and operative findings discussion","author":"Malacek","year":"2004","journal-title":"Neurosurgery"},{"key":"ref121","first-page":"1","article-title":"Surgical management of craniopharyngioma PediatrNeurosurg","volume":"13","author":"Hoffman","year":"1994"},{"key":"ref541","first-page":"283","article-title":"Surgical management of craniopharyngiomas","volume":"14","author":"Komotar","year":"2009"},{"key":"ref381","first-page":"39","article-title":"Surgical treatment of craniopharyngiomas endocrinological results","author":"Honegger","year":"1999","journal-title":"J Neurosurg"},{"key":"ref301","first-page":"122","article-title":"Craniopharyngioma in adults and children a study of surgical cases","volume":"31","author":"Van Effenterre","year":"2002","journal-title":"J Neurosurg"},{"key":"ref471","first-page":"628","article-title":"Origin of craniopharyngiomas implication on the growth pattern Nerv","volume":"21","author":"Wang","year":"2005","journal-title":"Syst"},{"key":"ref191","first-page":"219","article-title":"de de Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas discussion","volume":"20","author":"Divitiis","year":"2007","journal-title":"Neurosurgery"},{"key":"ref801","first-page":"567","article-title":"increased REM sleep with low cerebrospinal fluid hypocretin level in a patient after removal of craniopharyngioma","author":"Tachibana","year":"2005"},{"key":"ref611","first-page":"59","article-title":"The endoscopic extended transsphenoidal approach for craniopharyngiomas discussion","volume":"21","author":"Frank","year":"2006","journal-title":"Neurosurgery"},{"key":"ref531","first-page":"1","article-title":"Surgical management of craniopharyngioma PediatrNeurosurg","volume":"13","author":"Hoffman","year":"1994"},{"key":"ref61","first-page":"628","article-title":"Origin of craniopharyngiomas implication on the growth pattern Nerv","volume":"21","author":"Wang","year":"2005","journal-title":"Syst"},{"key":"ref791","first-page":"39","article-title":"Surgical treatment of craniopharyngiomas endocrinological results","author":"Honegger","year":"1999","journal-title":"J Neurosurg"},{"key":"ref11","first-page":"108","article-title":"AB PA CH AH DM Expanded endonasal approach a fully endoscopic transnasal approach for the resection of midline suprasellar craniopharyngiomas : a new classification based on the infundibulum","volume":"28","author":"Kassam","year":"2008","journal-title":"J Neurosurg"},{"key":"ref41","first-page":"153","article-title":"Anatomic relations of the arachnoidea around the pituitary stalk : relevance for surgical removal of craniopharyngiomas Wien","author":"Lu","year":"2011","journal-title":"Acta Neurochir"},{"key":"ref641","first-page":"70","article-title":"endonasal resection of craniopharyngiomas : analysis of outcome including extent of resection cerebrospinal fluid leak return to preoperative productivity and body mass index discussion","volume":"24","author":"Leng","year":"2012","journal-title":"Neurosurgery"}],"container-title":["Radiology and 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