{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:20:36Z","timestamp":1791159636477,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2014,11,5]],"date-time":"2014-11-05T00:00:00Z","timestamp":1415145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background. Many pathways seem to be involved in the regulation of the intra-S-phase checkpoint after exposure to ionizing radiation, but the role of p53 has proven to be rather elusive. Here we have a closer look at the progression of irradiated cells through S-phase in dependence of their p53 status.<\/jats:p>\n                  <jats:p>Materials and methods. Three pairs of tumour cell lines were used, each consisting of one p53 functional and one p53 non-functional line. Cells were labelled with bromodeoxyuridine(BrdU) immediately after irradiation, they were then incubated in label-free medium, and at different times afterwards their position within the S-phase was determined by means of flow cytometry.<\/jats:p>\n                  <jats:p>Results. While in the p53 deficient cells progression through S-phase was slowed significantly over at least a few hours, it was halted for just about an hour in the p53 proficient cells and then proceeded without further delay or even at a slightly accelerated pace.<\/jats:p>\n                  <jats:p>Conclusions. It is clear from the experiments presented here that p53 does play a role for the progress of cells through the S-phase after X-ray exposure, but the exact mechanisms by which replicon initiation and elongation is controlled in irradiated cells remain to be elucidated.<\/jats:p>","DOI":"10.2478\/raon-2014-0032","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T11:33:32Z","timestamp":1410262412000},"page":"354-360","source":"Crossref","is-referenced-by-count":3,"title":["Differential S-phase progression after irradiation of p53 functional versus non-functional tumour cells"],"prefix":"10.2478","volume":"48","author":[{"given":"Friedo","family":"Z\u00f6lzer","sequence":"first","affiliation":[{"name":"Institute of Medical Radiobiology, Medical Faculty, University Duisburg-Essen, Germany \/ Department of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia in \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamare","family":"Mu\u00dffeldt","sequence":"additional","affiliation":[{"name":"Institute of Medical Radiobiology, Medical Faculty, University Duisburg-Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Streffer","sequence":"additional","affiliation":[{"name":"Institute of Medical Radiobiology, Medical Faculty, University Duisburg-Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,11,5]]},"container-title":["Radiology and Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/raon\/48\/4\/article-p354.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/raon-2014-0032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:02:58Z","timestamp":1777485778000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/raon-2014-0032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,5]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,11,5]]},"published-print":{"date-parts":[[2014,12,1]]}},"alternative-id":["10.2478\/raon-2014-0032"],"URL":"https:\/\/doi.org\/10.2478\/raon-2014-0032","relation":{},"ISSN":["1581-3207"],"issn-type":[{"value":"1581-3207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,5]]}}}