{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:13:28Z","timestamp":1779106408971,"version":"3.51.4"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"Abstract<\/jats:title>\n \n Background.<\/jats:bold>\n Helicobacter pylori<\/jats:italic>\n infection is the main cause of gastric cancer. The disease progression is influenced by the host inflammatory responses, and cytokine single nucleotide polymorphisms (SNPs) may have a role in the course of the disease. The aim of our study was to investigate proinflammatory cytokine polymorphisms, previously associated with the development of gastric cancer, in a Slovenian population.\n <\/jats:p>\n \n Patients and methods.<\/jats:bold>\n In total 318 patients and controls were selected for the study and divided into three groups: (i) patients with gastric cancer (n = 58), (ii) patients with chronic gastritis (n = 60) and (iii) healthy control group (n = 200).\n H. pylori<\/jats:italic>\n infection in patient groups was determined by serology, histology and culture. Four proinflammatory gene polymorphisms were determined (IL-1\u03b2, IL-1r\u03b1, TNF-\u03b1, TLR-4) in all subjects.\n <\/jats:p>\n \n Results.<\/jats:bold>\n We found a statistically significant difference between males and females for the groups (p = 0.025). Odds ratio (OR) for gastric cancer risk for females was 0.557 (95% confidence interval [CI]: 0.233\u20151.329) and for chronic gastritis 2.073 (95% CI: 1.005\u20154.277).\n IL-1B-<\/jats:italic>\n 511*T\/T homozygous allele for cancer group had OR = 2.349 (95% CI: 0.583\u20159.462), heterozygous\n IL-1B-<\/jats:italic>\n 511*T had OR = 1.470 (95% CI: 0.583\u20153.709) and heterozygotes in\n TNF-A<\/jats:italic>\n -308 genotype for chronic gastritis had OR = 1.402 (95% CI: 0.626\u20153.139). Other alleles had OR less than 1.\n <\/jats:p>\n \n Conclusions.<\/jats:bold>\n We could not prove association between gastric cancer and chronic gastritis due to\n H. pylori<\/jats:italic>\n in any cytokine SNPs studied in Slovenian population. Other SNPs might be responsible besides infection with\n H. pylori<\/jats:italic>\n for the progression from atrophy to neoplastic transformation.\n <\/jats:p>","DOI":"10.2478\/raon-2014-0041","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T05:45:51Z","timestamp":1416203151000},"page":"256-264","source":"Crossref","is-referenced-by-count":15,"title":["The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infection"],"prefix":"10.2478","volume":"49","author":[{"given":"David","family":"Stubljar","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Immunology, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samo","family":"Jeverica","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomislav","family":"Jukic","sequence":"additional","affiliation":[{"name":"Medical faculty of Osijek, Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miha","family":"Skvarc","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeja","family":"Pintar","sequence":"additional","affiliation":[{"name":"Department of Abdominal Surgery, University Clinical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Tepes","sequence":"additional","affiliation":[{"name":"Abacus Medico Diagnostic Centre Rogaska, Rogaska Slatina, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajko","family":"Kavalar","sequence":"additional","affiliation":[{"name":"Department of Pathology, University medical Centre Maribor, Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borut","family":"Stabuc","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borut","family":"Peterlin","sequence":"additional","affiliation":[{"name":"Clinical Institute of Medical Genetics, University Clinical Centre Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alojz","family":"Ihan","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,8,21]]},"container-title":["Radiology and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/raon\/49\/3\/article-p256.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/raon-2014-0041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:24:10Z","timestamp":1779103450000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/raon-2014-0041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,21]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,8,21]]},"published-print":{"date-parts":[[2015,9,1]]}},"alternative-id":["10.2478\/raon-2014-0041"],"URL":"https:\/\/doi.org\/10.2478\/raon-2014-0041","relation":{},"ISSN":["1581-3207"],"issn-type":[{"value":"1581-3207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,21]]}}}