{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:20:45Z","timestamp":1783905645017,"version":"3.55.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_raon-2018-0038_s_006_w2aab3b7b5b1b6b1aab1c18b1Aa\">\n                    <jats:title id=\"d2367800e35931_w2aab3b7b5b1b6b1aab1c18b1aAa\">Background<\/jats:title>\n                    <jats:p>Locoregional recurrence is common in patients with locally advanced differentiated thyroid carcinoma (DTC). Our aim was to find out the rate of locoregional control of the disease after external beam radiotherapy (EBRT) of the neck and mediastinum in patients with DTC and pT4 tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2018-0038_s_007_w2aab3b7b5b1b6b1aab1c18b2Aa\">\n                    <jats:title id=\"d2367800e35940_w2aab3b7b5b1b6b1aab1c18b2aAa\">Patients and methods<\/jats:title>\n                    <jats:p>Altogether 91 patients (47 males, 44 females, median age 61 years) with DTC had EBRT of the neck and mediastinum as part of the multimodal treatment of pT4 tumor (63 cases pT4a, 28 cases pT4b) from the year 1973 to 2015. Data on clinical factors, histopathology and recurrence were collected. Disease-free, disease-specific and overall survival was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2018-0038_s_008_w2aab3b7b5b1b6b1aab1c18b3Aa\">\n                    <jats:title id=\"d2367800e35949_w2aab3b7b5b1b6b1aab1c18b3aAa\">Results<\/jats:title>\n                    <jats:p>Median tumor size was 5 cm (range 1\u201330 cm). Out of 91 patients, 23 had distant and 38 regional metastases. A total or near-total thyroidectomy, lobectomy, subtotal thyroidectomy and lymph node dissection was performed in 70%, 14%, 2% and 30% of cases, respectively. Thirteen percent of patients were not treated with surgery. All patients had EBRT and 39 had chemotherapy. Radioiodine (RAI) ablation of thyroid remnant and RAI therapy was applied in 90% and 40% of cases, respectively. Recurrence was diagnosed in 29\/64 patients without a persistent disease: locoregional and distant in 16 and 13 cases, respectively. Five-year and ten-year disease-free survival rate was 64% and 48%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2018-0038_s_009_w2aab3b7b5b1b6b1aab1c18b4Aa\">\n                    <jats:title id=\"d2367800e35957_w2aab3b7b5b1b6b1aab1c18b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>The majority of patients with DTC and pT4 tumors who were treated with EBRT of the neck and mediastinum region as part of multimodal treatment have long-lasting locoregional control of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2018-0038","type":"journal-article","created":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T05:07:57Z","timestamp":1537679277000},"page":"453-460","source":"Crossref","is-referenced-by-count":5,"title":["Locoregional disease control after external beam radiotherapy in 91 patients with differentiated thyroid carcinoma and pT4 tumor stage - a single institution experience"],"prefix":"10.2478","volume":"52","author":[{"given":"Nikola","family":"Besic","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology , Institute of Oncology Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Dremelj","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy , Institute of Oncology Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gasper","family":"Pilko","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology , Institute of Oncology Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"2026071214591311566_j_raon-2018-0038_ref_001_w2aab3b7b5b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Schlumberger MJ. 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