{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:09:42Z","timestamp":1783901382000,"version":"3.55.0"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_raon-2019-0014_s_006_w2aab3b7b1b1b6b1aab1c18b1Aa\">\n                    <jats:title id=\"d2965566e12393_w2aab3b7b1b1b6b1aab1c18b1aAa\">Background<\/jats:title>\n                    <jats:p>Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a solid tumor of extramedullary localization composed of malignant primitive myeloid cells. The purpose of the study was to identify clinical and imaging features in a large patient sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2019-0014_s_007_w2aab3b7b1b1b6b1aab1c18b2Aa\">\n                    <jats:title id=\"d2965566e12401_w2aab3b7b1b1b6b1aab1c18b2aAa\">Patients and methods<\/jats:title>\n                    <jats:p>Overall, 71 cases (34 females (47.9%) and 37 males (52.1%) with a median age of 56 (\u00b1 16 years) of histopathologically confirmed myeloid sarcoma were included into this study. The underlying hematological disease, occurrence, localizations and clinical symptoms as well as imaging features on computed tomography and magnetic resonance imaging were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2019-0014_s_008_w2aab3b7b1b1b6b1aab1c18b3Aa\">\n                    <jats:title id=\"d2965566e12409_w2aab3b7b1b1b6b1aab1c18b3aAa\">Results<\/jats:title>\n                    <jats:p>In 4 cases (5.63%) the manifestation of MS preceded the systemic hematological disease by a mean value of 3.8 \u00b1 2.1 months. In 13 cases, first presentation of MS occurred simultaneously with the initial diagnosis of leukemia, and 51 patients presented MS after the initial diagnosis of the underlying malignancy with a mean latency of 39.8 \u00b1 44.9 SD months. The visceral soft tissue was affected in 26 cases, followed by the cutis\/subcutis was affected in 21 cases. Further localizations were bones (n = 13), central nervous system (n = 9), lymph nodes (n = 4) and visceral organs (n = 9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2019-0014_s_009_w2aab3b7b1b1b6b1aab1c18b4Aa\">\n                    <jats:title id=\"d2965566e12417_w2aab3b7b1b1b6b1aab1c18b4aAa\">Conclusions<\/jats:title>\n                    <jats:p>MS is a rare complication of several hematological malignancies, predominantly of acute myeloid leukemia, which can affect any part of the body. In most cases it occurs after the diagnosis of the underlying malignancy, and affects frequently the cutis and subcutis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2019-0014","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T05:11:10Z","timestamp":1553058670000},"page":"213-218","source":"Crossref","is-referenced-by-count":25,"title":["Radiological and clinical patterns of myeloid sarcoma"],"prefix":"10.2478","volume":"53","author":[{"given":"Hans-Jonas","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Beimler","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Borte","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"P\u00f6nisch","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University Hospital Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Leipzig , Leipzig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"2026071214254923502_j_raon-2019-0014_ref_001_w2aab3b7b1b1b6b1ab1b5b1Aa","doi-asserted-by":"crossref","unstructured":"Liu PI, Ishimaru T, McGregor DH, Okada H, Steer Al. 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