{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:45:41Z","timestamp":1792665941723,"version":"4.5.0"},"reference-count":83,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_raon-2019-0036_s_011_w2aab3b8c17b1b7b1aab1c16b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood and adult-onset craniopharyngioma is a rare embryogenic tumor of the sellar, suprasellar, and parasellar region. Survival rates are high; however, tumor location and treatment sequalae including endocrine deficits, visual impairment, metabolic complications, cognitive and psychosocial deficits can significantly impair patient\u2019s quality of life. There is considerable controversy regarding the optimal management of craniopharyngiomas. Subtotal resection of the tumor followed by targeted irradiation to avoid further hypothalamic damage is currently indicated. Novel insights in the tumor\u2019s molecular pathology present the possibility for targeted therapy possibly decreasing the rate and severity of treatment-associated morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2019-0036_s_012_w2aab3b8c17b1b7b1aab1c16b2Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Craniopharyngioma should be seen as a chronic disease. To achieve optimal outcomes a multidisciplinary team of specialized neurosurgeons, neuro-radiologists, neuro-oncologists, pathologists and endocrinologists should be involved in the diagnosis, planning of the surgery, irradiation and long-term follow-up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2019-0036","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T05:04:17Z","timestamp":1571979857000},"page":"388-396","source":"Crossref","is-referenced-by-count":70,"title":["Advances in the management of craniopharyngioma in children and adults"],"prefix":"10.2478","volume":"53","author":[{"given":"Mojca","family":"Jensterle","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, University Medical Centre Ljubljana , Ljubljana , Slovenia"},{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soncka","family":"Jazbinsek","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Department of Endocrinology, Diabetes and Metabolism, University Children\u2019s Hospital, University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Bosnjak","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Department of Neurosurgery, University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Popovic","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Institute of Pathology, Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna Zadravec","family":"Zaletel","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Department of Radiotherapy, Institute of Oncology Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Vipotnik","family":"Vesnaver","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Clinical Institute of Radiology, University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Faganel","family":"Kotnik","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Department of Hematology and Oncology, University Children\u2019s Hospital, University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primoz","family":"Kotnik","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Department of Endocrinology, Diabetes and Metabolism, University Children\u2019s Hospital, University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"2026071214204714412_j_raon-2019-0036_ref_001_w2aab3b8c17b1b7b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM. The descriptive epidemiology of craniopharyngioma. J Neurosurg 1998; 89: 547-51. doi: 10.3171\/jns.1998.89.4.0547","DOI":"10.3171\/jns.1998.89.4.0547"},{"key":"2026071214204714412_j_raon-2019-0036_ref_002_w2aab3b8c17b1b7b1ab2ab2Aa","doi-asserted-by":"crossref","unstructured":"Nielsen EH, Feldt-Rasmussen U, Poulsgaard L, Kristensen LO, Astrup J, Jorgensen JO, et al. Incidence of craniopharyngioma in Denmark (n = 189) and estimated world incidence of craniopharyngioma in children and adults. J Neurooncol 2011; 104: 755-63. doi: 10.1007\/s11060-011-0540-6","DOI":"10.1007\/s11060-011-0540-6"},{"key":"2026071214204714412_j_raon-2019-0036_ref_003_w2aab3b8c17b1b7b1ab2ab3Aa","doi-asserted-by":"crossref","unstructured":"Ostrom QT, Gittleman H, Liao P, Vecchione Koval T, Wolinsky Y, Kruchko C, et al. CBTRUS Statistical Report: Primary brain and other central nervous system tumors diagnosed in the United States in 2010\u20132014. Neuro Oncol 2017; 19(Suppl. 5): 1-88. doi: 10.1093\/neuonc\/nox158","DOI":"10.1093\/neuonc\/nox158"},{"key":"2026071214204714412_j_raon-2019-0036_ref_004_w2aab3b8c17b1b7b1ab2ab4Aa","doi-asserted-by":"crossref","unstructured":"Ostrom QT, Gittleman H, Xu J, Kromer C, Wolinsky Y, Kruchko C, et al. CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013. Neuro Oncol 2016; 18: 1-75. doi: 10.1093\/neuonc\/now207","DOI":"10.1093\/neuonc\/now207"},{"key":"2026071214204714412_j_raon-2019-0036_ref_005_w2aab3b8c17b1b7b1ab2ab5Aa","unstructured":"Thapar, K, Kovacs K. Neoplasms of the sellar region. Russell and Rubinstein\u2019s Pathology of Tumors of the Nervous System, 6th Edn. 1998: 629-80."},{"key":"2026071214204714412_j_raon-2019-0036_ref_006_w2aab3b8c17b1b7b1ab2ab6Aa","doi-asserted-by":"crossref","unstructured":"Zada G, Lin N, Ojerholm E, Ramkissoon S, Laws ER. Craniopharyngioma and other cystic epithelial lesions of the sellar region: a review of clinical, imaging, and histopathological relationships. Neurosurg Focus 2010; 28: E4. doi: 10.3171\/2010.2.FOCUS09318","DOI":"10.3171\/2010.2.FOCUS09318"},{"key":"2026071214204714412_j_raon-2019-0036_ref_007_w2aab3b8c17b1b7b1ab2ab7Aa","doi-asserted-by":"crossref","unstructured":"Pascual JM, Prieto R, Rosdolsky M, Strauss S, Castro I, Verena D. Cystic tumors of the pituitary infundibulum : seminal autopsy specimens (1899 to 1904) that allowed clinical-pathological craniopharyngioma characterization. Pituitary 2018; 21: 393-405. doi:10.1007\/s11102-018-0889-z","DOI":"10.1007\/s11102-018-0889-z"},{"key":"2026071214204714412_j_raon-2019-0036_ref_008_w2aab3b8c17b1b7b1ab2ab8Aa","doi-asserted-by":"crossref","unstructured":"Wijnen M, Van Den Heuvel-Eibrink MM, Janssen JAMJL, Catsman-Berrevoets CE, Michiels EMC, Van Veelen-Vincent MLC, et al. Very long-Term sequelae of craniopharyngioma. Eur J Endocrinol 2017; 176: 755-67. doi: 10.1530\/EJE-17-0044","DOI":"10.1530\/EJE-17-0044"},{"key":"2026071214204714412_j_raon-2019-0036_ref_009_w2aab3b8c17b1b7b1ab2ab9Aa","doi-asserted-by":"crossref","unstructured":"Sterkenburg AS, Hoffmann A, Gebhardt U, Warmuth-Metz M, Daubenb\u00fcchel AMM, M\u00fcller HL. Survival, hypothalamic obesity, and neuropsychological\/psychosocial status after childhood-onset craniopharyngioma: Newly reported long-term outcomes. Neuro Oncol 2015; 17: 1029-38. doi: 10.1093\/neuonc\/nov044","DOI":"10.1093\/neuonc\/nov044"},{"key":"2026071214204714412_j_raon-2019-0036_ref_010_w2aab3b8c17b1b7b1ab2ac10Aa","doi-asserted-by":"crossref","unstructured":"Erfurth EM, Holmer H, Fjalldal SB. Mortality and morbidity in adult craniopharyngioma. Pituitary 2013; 16: 46-55. doi: 10.1007\/s11102-012-0428-2","DOI":"10.1007\/s11102-012-0428-2"},{"key":"2026071214204714412_j_raon-2019-0036_ref_011_w2aab3b8c17b1b7b1ab2ac11Aa","doi-asserted-by":"crossref","unstructured":"M\u00fcller HL, Merchant TE, Puget S, Martinez-Barbera JP. New outlook on the diagnosis, treatment and follow-up of childhood-onset craniopharyngioma. Nat Rev Endocrinol 2017; 13: 299-312. doi: 10.1038\/nrendo.2016.217","DOI":"10.1038\/nrendo.2016.217"},{"key":"2026071214204714412_j_raon-2019-0036_ref_012_w2aab3b8c17b1b7b1ab2ac12Aa","doi-asserted-by":"crossref","unstructured":"Heinks K, Boekhoff S, Hoffmann A, Warmuth-Metz M, Eveslage M, Peng J, et al. Quality of life and growth after childhood craniopharyngioma: results of the multinational trial KRANIOPHARYNGEOM 2007. Endocrine 2018; 59: 364-372. doi: 10.1007\/s12020-017-1489-9","DOI":"10.1007\/s12020-017-1489-9"},{"key":"2026071214204714412_j_raon-2019-0036_ref_013_w2aab3b8c17b1b7b1ab2ac13Aa","doi-asserted-by":"crossref","unstructured":"Karavitaki N, Brufani C, Warner JT, Adams CBT, Richards P, Ansorge O, et al. Craniopharyngiomas in children and adults: Systematic analysis of 121 cases with long-term follow-up. Clin Endocrinol (Oxf) 2005; 62: 397-409. doi: 10.1111\/j.1365-2265.2005.02231.x","DOI":"10.1111\/j.1365-2265.2005.02231.x"},{"key":"2026071214204714412_j_raon-2019-0036_ref_014_w2aab3b8c17b1b7b1ab2ac14Aa","doi-asserted-by":"crossref","unstructured":"Muller HL. Craniopharyngeoma - a chronic disease. Swiss Med Wkly 2018; 148: w14548. doi: 10.4414\/smw.2017.14548","DOI":"10.4414\/smw.2018.14548"},{"key":"2026071214204714412_j_raon-2019-0036_ref_015_w2aab3b8c17b1b7b1ab2ac15Aa","doi-asserted-by":"crossref","unstructured":"Schoenfeld A, Pekmezci M, Barnes MJ, Tihan T, Gupta N, Lamborn KR, et al. The superiority of conservative resection and adjuvant radiation for craniopharyngiomas. J Neurooncol 2012; 8: 133-9. doi: 10.1007\/s11060-012-0806-7","DOI":"10.1007\/s11060-012-0806-7"},{"key":"2026071214204714412_j_raon-2019-0036_ref_016_w2aab3b8c17b1b7b1ab2ac16Aa","doi-asserted-by":"crossref","unstructured":"Hoffmann A, Warmuth-Metz M, Gebhardt U, M\u00fcller H. Childhood Craniopharyngioma \u2013 Changes of Treatment Strategies in the Trials KRANIOPHARYNGEOM 2000\/2007. Klin Padiatr 2014; 226: 161-8. doi:10.1055\/s-0034-1368785","DOI":"10.1055\/s-0034-1368785"},{"key":"2026071214204714412_j_raon-2019-0036_ref_017_w2aab3b8c17b1b7b1ab2ac17Aa","doi-asserted-by":"crossref","unstructured":"Ajithkumar T, Mazhari AL, Stickan-Verf\u00fcrth M, Kramer PH, Fuentes CS, Lambert J, et al. Proton Therapy for Craniopharyngioma \u2014 An Early Report from a Single European Centre. Clin Oncol 2018; 30: 307-16. doi: 10.1016\/j. clon.2018.01.012","DOI":"10.1016\/j.clon.2018.01.012"},{"key":"2026071214204714412_j_raon-2019-0036_ref_018_w2aab3b8c17b1b7b1ab2ac18Aa","doi-asserted-by":"crossref","unstructured":"Kendall-Taylor P, J\u00f6nsson PJ, Abs R, Erfurth EM, Koltowska-H\u00e4ggstr\u00f6m M, Price DA, et al. The clinical, metabolic and endocrine features and the quality of life in adults with childhood-onset craniopharyngioma compared with adult-onset craniopharyngioma. Eur J Endocrinol 2005; 152: 557-67. doi: 10.1530\/eje.1.01877","DOI":"10.1530\/eje.1.01877"},{"key":"2026071214204714412_j_raon-2019-0036_ref_019_w2aab3b8c17b1b7b1ab2ac19Aa","doi-asserted-by":"crossref","unstructured":"Wijnen M, Olsson DS, Van Den Heuvel-Eibrink MM, Hammarstrand C, Janssen JAMJL, Van Der Lely AJ, et al. The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up. Eur J Endocrinol 2018; 178: 11-22. doi: 10.1530\/EJE-17-0387","DOI":"10.1530\/EJE-17-0387"},{"key":"2026071214204714412_j_raon-2019-0036_ref_020_w2aab3b8c17b1b7b1ab2ac20Aa","doi-asserted-by":"crossref","unstructured":"Andereggen L, Hess B, Andres RH, El-Koussy M, Mariani L, Raabe A, et al. A ten-year follow-up study of treatment outcome of craniopharyngiomas. Swiss Med Wkly 2018; 148: 1-8. doi: 10.4414\/smw.2017.14521","DOI":"10.4414\/smw.2018.14521"},{"key":"2026071214204714412_j_raon-2019-0036_ref_021_w2aab3b8c17b1b7b1ab2ac21Aa","doi-asserted-by":"crossref","unstructured":"Tan TSE, Patel L, Gopal-Kothandapani JS, Ehtisham S, Ikazoboh EC, Hayward R, et al. The neuroendocrine sequelae of paediatric craniopharyngioma: A 40-year meta-data analysis of 185 cases from three UK centres. Eur J Endocrinol 2017; 176: 359-69. doi: 10.1530\/EJE-16-0812","DOI":"10.1530\/EJE-16-0812"},{"key":"2026071214204714412_j_raon-2019-0036_ref_022_w2aab3b8c17b1b7b1ab2ac22Aa","doi-asserted-by":"crossref","unstructured":"Bosnjak R, Benedicic M, Vittori A. Early outcome in endoscopic extended endonasal approach for removal of supradiaphragmatic craniopharyngiomas: A case series and a comprehensive review. Radiol Oncol 2013; 47: 266-79. doi: 10.2478\/raon-2013-0036","DOI":"10.2478\/raon-2013-0036"},{"key":"2026071214204714412_j_raon-2019-0036_ref_023_w2aab3b8c17b1b7b1ab2ac23Aa","doi-asserted-by":"crossref","unstructured":"Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka, DJ, et al. Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. J Natl Cancer Inst 2016; 108: 1-5. doi: 10.1093\/jnci\/djv310","DOI":"10.1093\/jnci\/djv310"},{"key":"2026071214204714412_j_raon-2019-0036_ref_024_w2aab3b8c17b1b7b1ab2ac24Aa","doi-asserted-by":"crossref","unstructured":"Himes BT, Ruff MW, Gompel JJ Van, Park SS, Galanis E, Kaufmann TJ, et al. Recurrent papillary craniopharyngioma with Dabrafenib: case report. J Neurosurg 2018; 1: 1-5. doi: 10.3171\/2017.11.JNS172373","DOI":"10.1055\/s-0038-1633655"},{"key":"2026071214204714412_j_raon-2019-0036_ref_025_w2aab3b8c17b1b7b1ab2ac25Aa","doi-asserted-by":"crossref","unstructured":"Hoffmann A, Boekhoff S, Gebhardt U, Sterkenburg AS, Daubenb\u00fcchel AMM, Eveslage M, et al. History before diagnosis in childhood craniopharyngioma: Associations with initial presentation and long-term prognosis. Eur J Endocrinol 2015; 173: 853-62. doi: 10.1530\/EJE-15-0709","DOI":"10.1530\/EJE-15-0709"},{"key":"2026071214204714412_j_raon-2019-0036_ref_026_w2aab3b8c17b1b7b1ab2ac26Aa","doi-asserted-by":"crossref","unstructured":"Mortini P, Losa M, Pozzobon G, Barzaghi R, Riva M, Acerno S, et al. Neurosurgical treatment of craniopharyngioma in adults and children: early and long-term results in a large case series. J Neurosurg 2011; 114: 1350-9. doi: 10.3171\/2010.11.JNS10670","DOI":"10.3171\/2010.11.JNS10670"},{"key":"2026071214204714412_j_raon-2019-0036_ref_027_w2aab3b8c17b1b7b1ab2ac27Aa","doi-asserted-by":"crossref","unstructured":"Crotty TB, Scheithauer BW, Young WF, Davis DH, Shaw EG, Miller GM, et al. Papillary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg 1995; 83: 206-14. doi: 10.3171\/jns.1995.83.2.0206","DOI":"10.3171\/jns.1995.83.2.0206"},{"key":"2026071214204714412_j_raon-2019-0036_ref_028_w2aab3b8c17b1b7b1ab2ac28Aa","doi-asserted-by":"crossref","unstructured":"M\u00fcller HL. Hypothalamic involvement in craniopharyngioma\u2014Implications for surgical, radiooncological, and molecularly targeted treatment strategies. Pediatr Blood Cancer 2018; 65: e26936. doi: 10.1002\/pbc.26936","DOI":"10.1002\/pbc.26936"},{"key":"2026071214204714412_j_raon-2019-0036_ref_029_w2aab3b8c17b1b7b1ab2ac29Aa","doi-asserted-by":"crossref","unstructured":"Roth CL, Eslamy H, Werny D, Elfers C, Shaffer ML, Pihoker C, et al. Semiquantitative analysis of hypothalamic damage on MRI predicts risk for hypothalamic obesity. Obesity 2015; 23: 1226-33. doi: 10.1002\/oby.21067","DOI":"10.1002\/oby.21067"},{"key":"2026071214204714412_j_raon-2019-0036_ref_030_w2aab3b8c17b1b7b1ab2ac30Aa","doi-asserted-by":"crossref","unstructured":"Mortini P, Gagliardi F, Bailo M, Spina A, Parlangeli A, Falini A, et al. Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas. Endocrine 2016; 51: 148-62. doi: 10.1007\/s12020-015-0683-x","DOI":"10.1007\/s12020-015-0683-x"},{"key":"2026071214204714412_j_raon-2019-0036_ref_031_w2aab3b8c17b1b7b1ab2ac31Aa","doi-asserted-by":"crossref","unstructured":"M\u00fcller HL. Craniopharyngioma and hypothalamic injury: Latest insights into consequent eating disorders and obesity. Curr Opin Endocrinol Diabetes Obes 2016; 23: 81-9. doi: 10.1097\/MED.0000000000000214","DOI":"10.1097\/MED.0000000000000214"},{"key":"2026071214204714412_j_raon-2019-0036_ref_032_w2aab3b8c17b1b7b1ab2ac32Aa","doi-asserted-by":"crossref","unstructured":"Pascual JM, Prieto R, Carrasco R, Barrios L. Displacement of mammillary bodies by craniopharyngiomas involving the third ventricle: surgical-MRI correlation and use in topographical diagnosis. J Neurosurg 2013; 119: 381-405. doi: 10.3171\/2013.1.JNS111722","DOI":"10.3171\/2013.1.JNS111722"},{"key":"2026071214204714412_j_raon-2019-0036_ref_033_w2aab3b8c17b1b7b1ab2ac33Aa","doi-asserted-by":"crossref","unstructured":"Zoicas F, Sch\u00f6fl C. Craniopharyngioma in Adults. Front Endocrinol (Lausanne) 2012; 3: 46. doi: 10.3389\/fendo.2012.00046","DOI":"10.3389\/fendo.2012.00046"},{"key":"2026071214204714412_j_raon-2019-0036_ref_034_w2aab3b8c17b1b7b1ab2ac34Aa","doi-asserted-by":"crossref","unstructured":"Amelot A, Borha A, Calmon R, Barbet P, Puget S. Child dermoid cyst mimicking a craniopharyngioma: the benefit of MRI T2-weighted diffusion sequence. Child\u2019s Nerv Syst 2018; 34: 359-62. doi: 10.1007\/s00381-017-3602-z","DOI":"10.1007\/s00381-017-3602-z"},{"key":"2026071214204714412_j_raon-2019-0036_ref_035_w2aab3b8c17b1b7b1ab2ac35Aa","doi-asserted-by":"crossref","unstructured":"Puget S, Garnett M, Wray A, Grill J, Habrand JL, Bodaert N, et al. Pediatric craniopharyngiomas: classification and treatment according to the degree of hypothalamic involvement. J Neurosurg Pediatr 2007; 106: 3-12. doi: 10.3171\/ped.2007.106.1.3","DOI":"10.3171\/ped.2007.106.1.3"},{"key":"2026071214204714412_j_raon-2019-0036_ref_036_w2aab3b8c17b1b7b1ab2ac36Aa","doi-asserted-by":"crossref","unstructured":"Elowe-Gruau E, Beltrand J, Brauner R, Pinto G, Samara-Boustani D, Thalassinos C, et al. Childhood craniopharyngioma: Hypothalamus-sparing surgery decreases the risk of obesity. J Clin Endocrinol Metab 2013; 98: 2376-82. doi: 10.1210\/jc.2012-3928","DOI":"10.1210\/jc.2012-3928"},{"key":"2026071214204714412_j_raon-2019-0036_ref_037_w2aab3b8c17b1b7b1ab2ac37Aa","doi-asserted-by":"crossref","unstructured":"Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, et al. Craniopharyngiomas: A Clinicopathological Analysis of Factors Predictive of Recurrence and Functional Outcome. Neurosurgery 1994; 35: 1001-11. http:\/\/dx.doi.org\/10.1227\/00006123-199412000-00001","DOI":"10.1097\/00006123-199412000-00001"},{"key":"2026071214204714412_j_raon-2019-0036_ref_038_w2aab3b8c17b1b7b1ab2ac38Aa","doi-asserted-by":"crossref","unstructured":"M\u00fcller HL, Gebhardt U, Teske C, Faldum A, Zwiener I, Warmuth-Metz M, et al. Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: Results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol 2011; 165: 17-24. doi: 10.1530\/EJE-11-0158","DOI":"10.1530\/EJE-11-0158"},{"key":"2026071214204714412_j_raon-2019-0036_ref_039_w2aab3b8c17b1b7b1ab2ac39Aa","doi-asserted-by":"crossref","unstructured":"Gu Y, Zhang X. Letter to the Editor: Mammillary body angle and craniopharyngioma. J Neurosurg 2014; 120: 1241-5. doi: 10.3171\/2013.11.JNS132343","DOI":"10.3171\/2013.11.JNS132343"},{"key":"2026071214204714412_j_raon-2019-0036_ref_040_w2aab3b8c17b1b7b1ab2ac40Aa","doi-asserted-by":"crossref","unstructured":"Coury JR, Davis BN, Koumas CP, Manzano GS, Dehdashti AR. Histopathological and molecular predictors of growth patterns and recurrence in craniopharyngiomas: a systematic review. Neurosurg Rev 2018. doi: 10.1007\/s10143-018-0978-5","DOI":"10.1007\/s10143-018-0978-5"},{"key":"2026071214204714412_j_raon-2019-0036_ref_041_w2aab3b8c17b1b7b1ab2ac41Aa","doi-asserted-by":"crossref","unstructured":"Karavitaki N, Cudlip S, Adams CB, and Wass JA. Craniopharyngiomas. Endocr Rev 2006; 27: 371-97. doi: 10.1210\/er.2006-0002","DOI":"10.1210\/er.2006-0002"},{"key":"2026071214204714412_j_raon-2019-0036_ref_042_w2aab3b8c17b1b7b1ab2ac42Aa","doi-asserted-by":"crossref","unstructured":"Clark AJ, Cage TA, Aranda D, Parsa AT, Sun PP, Auguste KI, et al. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Child\u2019s Nerv Syst 2013; 29: 231-8. doi: 10.1007\/s00381-012-1926-2","DOI":"10.1007\/s00381-012-1926-2"},{"key":"2026071214204714412_j_raon-2019-0036_ref_043_w2aab3b8c17b1b7b1ab2ac43Aa","doi-asserted-by":"crossref","unstructured":"Kiehna EN, Merchant TE. Radiation therapy for pediatric craniopharyngioma. Neurosurg Focus 2010; 28: E10. doi: 10.3171\/2010.1.FOCUS09297","DOI":"10.3171\/2010.1.FOCUS09297"},{"key":"2026071214204714412_j_raon-2019-0036_ref_044_w2aab3b8c17b1b7b1ab2ac44Aa","doi-asserted-by":"crossref","unstructured":"O\u2019steen L, Indelicato DJ. Advances in the management of craniopharyngioma. F1000Research 2018; 7: 1632. doi:10.12688\/f1000research.15834.1","DOI":"10.12688\/f1000research.15834.1"},{"key":"2026071214204714412_j_raon-2019-0036_ref_045_w2aab3b8c17b1b7b1ab2ac45Aa","doi-asserted-by":"crossref","unstructured":"Kortmann RD. Different Approaches in Radiation Therapy of Craniopharyngioma. Front Endocrinol (Lausanne) 2011; 2: 100. doi: 10.3389\/fendo.2011.00100","DOI":"10.3389\/fendo.2011.00100"},{"key":"2026071214204714412_j_raon-2019-0036_ref_046_w2aab3b8c17b1b7b1ab2ac46Aa","doi-asserted-by":"crossref","unstructured":"Bishop AJ, Greenfield B, Mahajan A, Paulino AC, Okcu MF, Allen, PK, et al. Proton beam therapy versus conformal photon radiation therapy for childhood craniopharyngioma: Multi-institutional analysis of outcomes, cyst dynamics, and toxicity. Int J Radiat Oncol Biol Phys 2014; 90: 354-61. doi: 10.1016\/j.ijrobp.2014.05.051","DOI":"10.1016\/j.ijrobp.2014.05.051"},{"key":"2026071214204714412_j_raon-2019-0036_ref_047_w2aab3b8c17b1b7b1ab2ac47Aa","doi-asserted-by":"crossref","unstructured":"Harrabi SB, Adeberg S, Welzel T, Rieken S, Habermehl D, Debus J, et al. Long term results after fractionated stereotactic radiotherapy (FSRT) in patients with craniopharyngioma: maximal tumor control with minimal side effects. Radiat Oncol 2014; 9: 203. doi: 10.1186\/1748-717X-9-203","DOI":"10.1186\/1748-717X-9-203"},{"key":"2026071214204714412_j_raon-2019-0036_ref_048_w2aab3b8c17b1b7b1ab2ac48Aa","doi-asserted-by":"crossref","unstructured":"Beltran C, Roca M, Merchant TE. On the Benefits and Risks of Proton Therapy in Pediatric Craniopharyngioma. Int J Radiat Oncol 2012; 82: 281-7. doi: 10.1016\/j.ijrobp.2011.01.005","DOI":"10.1016\/j.ijrobp.2011.01.005"},{"key":"2026071214204714412_j_raon-2019-0036_ref_049_w2aab3b8c17b1b7b1ab2ac49Aa","doi-asserted-by":"crossref","unstructured":"Regine WF, Kramer S. Pediatric craniopharyngiomas: Long term results of combined treatment with surgery and radiation. Int J Radiat Oncol 1992; 24: 611-17. doi: 10.1016\/0360-3016(92)90705-M","DOI":"10.1016\/0360-3016(92)90705-M"},{"key":"2026071214204714412_j_raon-2019-0036_ref_050_w2aab3b8c17b1b7b1ab2ac50Aa","doi-asserted-by":"crossref","unstructured":"Winkfield KM, Linsenmeier C, Yock TI, Grant PE, Yeap BY, Butler WE, et al. Surveillance of Craniopharyngioma Cyst Growth in Children Treated With Proton Radiotherapy Int J Radiat Oncol 2009; 73: 716-21. doi: https:\/\/doi.org\/10.1016\/j.ijrobp.2008.05.010","DOI":"10.1016\/j.ijrobp.2008.05.010"},{"key":"2026071214204714412_j_raon-2019-0036_ref_051_w2aab3b8c17b1b7b1ab2ac51Aa","doi-asserted-by":"crossref","unstructured":"Losa M, Pieri V, Bailo M, Gagliardi F, Barzaghi LR, Gioia L, et al. Single fraction and multisession Gamma Knife radiosurgery for craniopharyngioma. Pituitary 2018; 21: 499-506. doi: 10.1007\/s11102-018-0903-5","DOI":"10.1007\/s11102-018-0903-5"},{"key":"2026071214204714412_j_raon-2019-0036_ref_052_w2aab3b8c17b1b7b1ab2ac52Aa","doi-asserted-by":"crossref","unstructured":"Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnr\u00fcbl F, et al. Common mutations of \u03b2-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region. Acta Neuropathol 2005; 109: 589-97. doi: 10.1007\/s00401-005-1004-x","DOI":"10.1007\/s00401-005-1004-x"},{"key":"2026071214204714412_j_raon-2019-0036_ref_053_w2aab3b8c17b1b7b1ab2ac53Aa","doi-asserted-by":"crossref","unstructured":"Pekmezci M, Louie J, Gupta N, Bloomer MM, Tihan T. Clinicopathological characteristics of adamantinomatous and papillary craniopharyngiomas: University of California, San Francisco experience 1985-2005. Neurosurgery 2010; 67: 1341-9. doi: 10.1227\/NEU.0b013e3181f2b583","DOI":"10.1227\/NEU.0b013e3181f2b583"},{"key":"2026071214204714412_j_raon-2019-0036_ref_054_w2aab3b8c17b1b7b1ab2ac54Aa","doi-asserted-by":"crossref","unstructured":"Prieto R, Pascual JM. Can tissue biomarkers reliably predict the biological behavior of craniopharyngiomas? A comprehensive overview. Pituitary 2018; 21: 431-42. doi: 10.1007\/s11102-018-0890-6","DOI":"10.1007\/s11102-018-0890-6"},{"key":"2026071214204714412_j_raon-2019-0036_ref_055_w2aab3b8c17b1b7b1ab2ac55Aa","doi-asserted-by":"crossref","unstructured":"Apps JR, Martinez-Barbera JP. Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice. Neurosurg Focus 2016; 41: E4. doi: 10.3171\/2016.8.FOCUS16307","DOI":"10.3171\/2016.8.FOCUS16307"},{"key":"2026071214204714412_j_raon-2019-0036_ref_056_w2aab3b8c17b1b7b1ab2ac56Aa","doi-asserted-by":"crossref","unstructured":"Brastianos PK, Taylor-Weiner A, Manley PE, Robert T, Dias-Santagata D, Thorner AR, et al. Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. Nat Genet 2014; 46: 161-5. doi: 10.1038\/ng.2868","DOI":"10.1038\/ng.2868"},{"key":"2026071214204714412_j_raon-2019-0036_ref_057_w2aab3b8c17b1b7b1ab2ac57Aa","doi-asserted-by":"crossref","unstructured":"Apps JR, Carreno G, Gonzalez-Meljem JM, Haston S, Guiho R, Cooper JE, et al. Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK\/ERK pathway as a novel therapeutic target. Acta Neuropathol 2018; 135: 757-77. doi: 10.1007\/s00401-018-1830-2","DOI":"10.1007\/s00401-018-1830-2"},{"key":"2026071214204714412_j_raon-2019-0036_ref_058_w2aab3b8c17b1b7b1ab2ac58Aa","doi-asserted-by":"crossref","unstructured":"Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949. doi: 10.1038\/nature00766","DOI":"10.1038\/nature00766"},{"key":"2026071214204714412_j_raon-2019-0036_ref_059_w2aab3b8c17b1b7b1ab2ac59Aa","doi-asserted-by":"crossref","unstructured":"Larkin SJ, Preda V, Karavitaki N, Grossman A, Ansorge O. BRAF V600E mutations are characteristic for papillary craniopharyngioma and may coexist with CTNNB1-mutated adamantinomatous craniopharyngioma. Acta Neuropathol 2014; 127: 927-9. doi: 10.1007\/s00401-014-1270-6","DOI":"10.1007\/s00401-014-1270-6"},{"key":"2026071214204714412_j_raon-2019-0036_ref_060_w2aab3b8c17b1b7b1ab2ac60Aa","doi-asserted-by":"crossref","unstructured":"Bi WL, Larsen AG, Dunn IF. Genomic Alterations in Sporadic Pituitary Tumors. Curr Neurol Neurosci Rep 2018; 18: 4. doi:10.1007\/s11910-018-0811-0","DOI":"10.1007\/s11910-018-0811-0"},{"key":"2026071214204714412_j_raon-2019-0036_ref_061_w2aab3b8c17b1b7b1ab2ac61Aa","doi-asserted-by":"crossref","unstructured":"Aylwin SJB, Bodi I, Beaney R. Pronounced response of papillary craniopharyngioma to treatment with vemurafenib, a BRAF inhibitor. Pituitary 2016; 19: 544-6. doi: 10.1007\/s11102-015-0663-4","DOI":"10.1007\/s11102-015-0663-4"},{"key":"2026071214204714412_j_raon-2019-0036_ref_062_w2aab3b8c17b1b7b1ab2ac62Aa","doi-asserted-by":"crossref","unstructured":"Roque A, Odia Y. BRAF-V600E mutant papillary craniopharyngioma dramatically responds to combination BRAF and MEK inhibitors. CNS Oncol 2017; 6: 95-9. doi: 10.2217\/cns-2016-0034","DOI":"10.2217\/cns-2016-0034"},{"key":"2026071214204714412_j_raon-2019-0036_ref_063_w2aab3b8c17b1b7b1ab2ac63Aa","doi-asserted-by":"crossref","unstructured":"Rostami E, Witt Nystr\u00f6m P, Libard S, Wikstr\u00f6m J, Casar-Borota O, Gudjonsson O. Recurrent papillary craniopharyngioma with BRAFV600E mutation treated with neoadjuvant-targeted therapy. Acta Neurochir (Wien) 2017; 159: 2217-21. doi: 10.1007\/s00701-017-3311-0","DOI":"10.1007\/s00701-017-3311-0"},{"key":"2026071214204714412_j_raon-2019-0036_ref_064_w2aab3b8c17b1b7b1ab2ac64Aa","doi-asserted-by":"crossref","unstructured":"Caldarelli M, Massimi L, Tamburrini G, Cappa M, Di Rocco C. Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome. Child\u2019s Nerv Syst 2005; 21: 747-57. doi: 10.1007\/s00381-005-1186-5","DOI":"10.1007\/s00381-005-1186-5"},{"key":"2026071214204714412_j_raon-2019-0036_ref_065_w2aab3b8c17b1b7b1ab2ac65Aa","doi-asserted-by":"crossref","unstructured":"M\u00fcller HL. Childhood craniopharyngioma. Pituitary 2013; 16: 56-67. doi: 10.1007\/s11102-012-0401-0","DOI":"10.1007\/s11102-012-0401-0"},{"key":"2026071214204714412_j_raon-2019-0036_ref_066_w2aab3b8c17b1b7b1ab2ac66Aa","doi-asserted-by":"crossref","unstructured":"Boekhoff S, Bogusz A, Sterkenburg AS, Eveslage M, M\u00fcller HL. Long-term effects of growth hormone replacement therapy in childhood-onset craniopharyngioma: results of the German Craniopharyngioma Registry (HIT-Endo). Eur J Endocrinol 2018; 179: 331-41. doi: 10.1530\/EJE-18-0505.","DOI":"10.1530\/EJE-18-0505"},{"key":"2026071214204714412_j_raon-2019-0036_ref_067_w2aab3b8c17b1b7b1ab2ac67Aa","doi-asserted-by":"crossref","unstructured":"Geffner ME. The growth without growth hormone syndrome. Endocrinol Metab Clin 1996; 25: 649-63. doi: 10.1016\/S0889-8529(05)70345-5","DOI":"10.1016\/S0889-8529(05)70345-5"},{"key":"2026071214204714412_j_raon-2019-0036_ref_068_w2aab3b8c17b1b7b1ab2ac68Aa","doi-asserted-by":"crossref","unstructured":"Holmer H, Pozarek G, Wirf\u00e4lt E, Popovic V, Ekman B, Bj\u00f6rk J, et al. Reduced energy expenditure and impaired feeding-related signals but not high energy intake reinforces hypothalamic obesity in adults with childhood onset craniopharyngioma J Clin Endocrinol Metab 2010; 95: 5395-402. doi: 10.1210\/jc.2010-0993","DOI":"10.1210\/jc.2010-0993"},{"key":"2026071214204714412_j_raon-2019-0036_ref_069_w2aab3b8c17b1b7b1ab2ac69Aa","doi-asserted-by":"crossref","unstructured":"Bereket A, Kiess W, Lustig RH, M\u00fcller HL, Goldstone AP, Weiss R, et al. Hypothalamic obesity in children. Obes Rev 2012; 13: 780-98. doi: 10.1111\/j.1467-789X.2012.01004","DOI":"10.1111\/j.1467-789X.2012.01004.x"},{"key":"2026071214204714412_j_raon-2019-0036_ref_070_w2aab3b8c17b1b7b1ab2ac70Aa","doi-asserted-by":"crossref","unstructured":"Hoffmann A, Bootsveld K, Gebhardt U, Daubenb\u00fcchel AMM, Sterkenburg AS, M\u00fcller HL. Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma. Eur J Endocrinol 2015; 173: 389-97. doi: 10.1530\/EJE-15-0422","DOI":"10.1530\/EJE-15-0422"},{"key":"2026071214204714412_j_raon-2019-0036_ref_071_w2aab3b8c17b1b7b1ab2ac71Aa","doi-asserted-by":"crossref","unstructured":"Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, et al. Association between premature mortality and hypopituitarism. Lancet 2001; 357: 425-31. doi: 10.1016\/S0140-6736(00)04006-X","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"2026071214204714412_j_raon-2019-0036_ref_072_w2aab3b8c17b1b7b1ab2ac72Aa","doi-asserted-by":"crossref","unstructured":"Ros\u00e9n T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990; 336: 285-8. doi: 10.1016\/0140-6736(90)91812-O","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"2026071214204714412_j_raon-2019-0036_ref_073_w2aab3b8c17b1b7b1ab2ac73Aa","doi-asserted-by":"crossref","unstructured":"B\u00fclow B, Attewell R, Hagmar L, Malmstr\u00f6m P, Nordstr\u00f6m CH, Erfurth EM. Postoperative prognosis in craniopharyngioma with respect to cardiovascular mortality, survival, and tumor recurrence. J Clin Endocrinol Metab 1998; 83: 3897-904. doi: 10.1210\/jc.83.11.3897","DOI":"10.1210\/jcem.83.11.5240"},{"key":"2026071214204714412_j_raon-2019-0036_ref_074_w2aab3b8c17b1b7b1ab2ac74Aa","doi-asserted-by":"crossref","unstructured":"Holmer H, Ekman B, Bj\u00f6rk J, Nordst\u00f6m CH, Popovic V, Siversson AB, et al. Hypothalamic involvement predicts cardiovascular risk in adults with childhood onset craniopharyngioma on long-term GH therapy. Eur J Endocrinol 2009; 161: 671-9. doi: 10.1530\/EJE-09-0449","DOI":"10.1530\/EJE-09-0449"},{"key":"2026071214204714412_j_raon-2019-0036_ref_075_w2aab3b8c17b1b7b1ab2ac75Aa","unstructured":"Defoort-Dhellemmes S, Moritz F, Bouacha I, Vinchon M. Craniopharyngioma: ophthalmological aspects at diagnosis. J Pediatr Endocrinol Metab 2006; 19(Suppl 1): 321-4. http:\/\/europepmc.org\/abstract\/MED\/16700306"},{"key":"2026071214204714412_j_raon-2019-0036_ref_076_w2aab3b8c17b1b7b1ab2ac76Aa","doi-asserted-by":"crossref","unstructured":"Pierre-Kahn A, Recassens C, Pinto G, Thalassinos C, Chokron S, Soubervielle JC, et al. Social and psycho-intellectual outcome following radical removal of craniopharyngiomas in childhood. A prospective series. Child\u2019s Nerv Syst 2005; 21: 817-24. doi: 10.1007\/s00381-005-1205-6","DOI":"10.1007\/s00381-005-1205-6"},{"key":"2026071214204714412_j_raon-2019-0036_ref_077_w2aab3b8c17b1b7b1ab2ac77Aa","doi-asserted-by":"crossref","unstructured":"Riva D, Pantaleoni C, Devoti M, Saletti V, Nichelli F, Giorgi C. Late neuropsychological and behavioural outcome of children surgically treated for craniopharyngioma. Child\u2019s Nerv Syst 1998; 14: 179-84. doi: 10.1007\/s003810050207","DOI":"10.1007\/s003810050207"},{"key":"2026071214204714412_j_raon-2019-0036_ref_078_w2aab3b8c17b1b7b1ab2ac78Aa","doi-asserted-by":"crossref","unstructured":"\u00d6zyurt J, M\u00fcller HL, Warmuth-Metz M, Thiel CM. Hypothalamic tumors impact gray and white matter volumes in fronto-limbic brain areas. Cortex 2017; 89: 98-110. doi: 10.1016\/j.cortex.2017.01.017","DOI":"10.1016\/j.cortex.2017.01.017"},{"key":"2026071214204714412_j_raon-2019-0036_ref_079_w2aab3b8c17b1b7b1ab2ac79Aa","doi-asserted-by":"crossref","unstructured":"Poretti A, Grotzer MA, Ribi K, Schonle E, Boltshauser E. Outcome of craniopharyngioma in complications and quality of life. Dev Med Child Neurol 2004; 46: 220-9. doi: 10.1111\/j.1469-8749.2004.tb00476.x","DOI":"10.1111\/j.1469-8749.2004.tb00476.x"},{"key":"2026071214204714412_j_raon-2019-0036_ref_080_w2aab3b8c17b1b7b1ab2ac80Aa","doi-asserted-by":"crossref","unstructured":"Dekkers OM, Biermasz NR, Smith JWA, Groot LE, Roelfsema F, Romijn, JA, et al. Quality of life in treated adult craniopharyngioma patients. Eur J Endocrinol 2006; 154: 483-9. doi: 10.1530\/eje.1.02114","DOI":"10.1530\/eje.1.02114"},{"key":"2026071214204714412_j_raon-2019-0036_ref_081_w2aab3b8c17b1b7b1ab2ac81Aa","doi-asserted-by":"crossref","unstructured":"Gautier A, Godbout A, Grosheny C, Tejedor I, Coudert M, Courtillot C, et al. Markers of recurrence and long-term morbidity in craniopharyngioma: a systematic analysis of 171 patients. J Clin Endocrinol Metab 2012; 97: 1258-67. doi:10.1210\/jc.2011-2817","DOI":"10.1210\/jc.2011-2817"},{"key":"2026071214204714412_j_raon-2019-0036_ref_082_w2aab3b8c17b1b7b1ab2ac82Aa","doi-asserted-by":"crossref","unstructured":"van Iersel L, Meijneke RWH, Schouten-van Meeteren AYN, Reneman L, de Win MM, van Trotsenburg ASP, et al. The development of hypothalamic obesity in craniopharyngioma patients: a risk factor analysis in a well-defined cohort. Pediatr Blood Cancer 2018; 65: e26911. doi: 10.1002\/pbc.26911","DOI":"10.1002\/pbc.26911"},{"key":"2026071214204714412_j_raon-2019-0036_ref_083_w2aab3b8c17b1b7b1ab2ac83Aa","doi-asserted-by":"crossref","unstructured":"Borrill R, Cheesman E, Stivaros S, Kamaly-Asl ID, Gnanalingham K, Kilday J-P. Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature. Child\u2019s Nerv Syst 2019; 35: 169-73. doi:10.1007\/s00381-018-3925-4.","DOI":"10.1007\/s00381-018-3925-4"}],"container-title":["Radiology and Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/raon\/53\/4\/article-p388.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/raon-2019-0036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T23:13:33Z","timestamp":1783898013000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/raon-2019-0036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":83,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,10,25]]},"published-print":{"date-parts":[[2019,10,25]]}},"alternative-id":["10.2478\/raon-2019-0036"],"URL":"https:\/\/doi.org\/10.2478\/raon-2019-0036","relation":{},"ISSN":["1581-3207"],"issn-type":[{"value":"1581-3207","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,25]]}}}