{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:49:06Z","timestamp":1782524946745,"version":"3.54.5"},"reference-count":59,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_raon-2020-0057_s_005_w2aab3b7d133b1b6b1aab1c16b1Aa\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Asbestos exposure is associated with the development of pleural plaques as well as malignant mesothelioma (MM). Asbestos fibres activate macrophages, leading to the release of inflammatory mediators including interleukin 1 beta (IL-1\u03b2). The expression of IL-1\u03b2 may be influenced by genetic variability of\n                      <jats:italic>IL1B<\/jats:italic>\n                      gene or regulatory microRNAs (miRNAs). This study investigated the effect of polymorphisms in\n                      <jats:italic>IL1B<\/jats:italic>\n                      and\n                      <jats:italic>MIR146A<\/jats:italic>\n                      genes on the risk of developing pleural plaques and MM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2020-0057_s_006_w2aab3b7d133b1b6b1aab1c16b2Aa\">\n                    <jats:title>Subjects and methods<\/jats:title>\n                    <jats:p>\n                      In total, 394 patients with pleural plaques, 277 patients with MM, and 175 healthy control subjects were genotyped for\n                      <jats:italic>IL1B<\/jats:italic>\n                      and\n                      <jats:italic>MIR146A<\/jats:italic>\n                      polymorphisms. Logistic regression was used in statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2020-0057_s_007_w2aab3b7d133b1b6b1aab1c16b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found no association between\n                      <jats:italic>MIR146A<\/jats:italic>\n                      and\n                      <jats:italic>IL1B<\/jats:italic>\n                      genotypes, and the risk of pleural plaques.\n                      <jats:italic>MIR146A<\/jats:italic>\n                      rs2910164 was significantly associated with a decreased risk of MM (OR = 0.31, 95% CI = 0.13\u20130.73, p = 0.008). Carriers of two polymorphic alleles had a lower risk of developing MM, even after adjustment for gender and age (OR = 0.34, 95% CI = 0.14\u20130.85, p = 0.020). Among patients with known asbestos exposure, carriers of at least one polymorphic\n                      <jats:italic>IL1B<\/jats:italic>\n                      rs1143623 allele also had a lower risk of MM in multivariable analysis (OR = 0.50, 95% CI = 0.28\u20130.92, p = 0.025). The interaction between\n                      <jats:italic>IL1B<\/jats:italic>\n                      rs1143623 and\n                      <jats:italic>IL1B<\/jats:italic>\n                      rs1071676 was significantly associated with an increased risk of MM (p = 0.050).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2020-0057_s_008_w2aab3b7d133b1b6b1aab1c16b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that genetic variability of inflammatory mediator IL-1\u03b2 could contribute to the risk of developing MM, but not pleural plaques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2020-0057","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T01:27:08Z","timestamp":1603502828000},"page":"429-436","source":"Crossref","is-referenced-by-count":7,"title":["The influence of genetic variability in\n                    <i>IL1B<\/i>\n                    and\n                    <i>MIR146A<\/i>\n                    on the risk of pleural plaques and malignant mesothelioma"],"prefix":"10.2478","volume":"54","author":[{"given":"Petra","family":"Piber","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neza","family":"Vavpetic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Goricar","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Dolzan","sequence":"additional","affiliation":[{"name":"Pharmacogenetics Laboratory, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viljem","family":"Kovac","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Institute of Oncology Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alenka","family":"Franko","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana , Ljubljana , Slovenia"},{"name":"Clinical Institute of Occupational Medicine, University Medical Centre Ljubljana , Ljubljana , Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"2026042913142225789_j_raon-2020-0057_ref_001_w2aab3b7d133b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Kovac V, Dodic-Fikfak M, Arneric N, Dolzan V, Franko A. 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