{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T09:06:53Z","timestamp":1788599213476,"version":"build-2803163510"},"reference-count":36,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_raon-2023-0013_s_006\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thymomas belong to rare tumors giving rise to thymic epithelial tissue. There is a classification of several forms of thymoma: A, AB, B1, B2, B3, thymic carcinoma (TC) and thymic neuroendocrine thymoma. In this meta-analysis study, we have focused on thymoma using articles based on the disease\u2019s next-generation sequencing (NGS) genomic profiling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2023-0013_s_007\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      We conducted a systematic review and meta-analysis of the prevalence of studies that discovered the genes and variants occurring in the less aggressive forms of the thymic epithelial tumors. Studies published before 12\n                      <jats:sup>th<\/jats:sup>\n                      December 2022 were identified through PubMed, Web of Science (WoS), and SCOPUS databases. Two reviewers have searched for the bases and selected the articles for the final analysis, based on well-defined exclusion and inclusion criteria.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2023-0013_s_008\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Finally, 12 publications were included in the qualitative as well as quantitative analysis. The three genes,\n                      <jats:italic>GTF2I<\/jats:italic>\n                      ,\n                      <jats:italic>TP53<\/jats:italic>\n                      , and\n                      <jats:italic>HRAS<\/jats:italic>\n                      , emerged as disease-significant in the observed studies. The Odds Ratio for all three extracted genes\n                      <jats:italic>GTF2I<\/jats:italic>\n                      (OR = 1.58, CI [1.51, 1.66] p &lt; 0.00001)\n                      <jats:italic>, TP53<\/jats:italic>\n                      (OR = 1.36, CI [1.12, 1.65], p &lt; 0.002), and\n                      <jats:italic>HRAS<\/jats:italic>\n                      (OR = 1.02, CI [1.00, 1.04], p &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_raon-2023-0013_s_009\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      According to obtained data, we noticed that the\n                      <jats:italic>GTF2I<\/jats:italic>\n                      gene exhibits a significant prevalence in the cohort of observed thymoma patients. Moreover, analyzing published articles NGS has suggested\n                      <jats:italic>GTF2I, TP53<\/jats:italic>\n                      , and\n                      <jats:italic>HRAS<\/jats:italic>\n                      genes as the most frequently mutated genes in thymoma that have pathogenic single nucleotide variants (SNV) and Insertion\/Deletion (InDel), which contribute to disease development and progression. These variants could be valuable biomarkers and target points specific to thymoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2023-0013","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T07:21:58Z","timestamp":1679383318000},"page":"12-19","source":"Crossref","is-referenced-by-count":8,"title":["Molecular profiling of rare thymoma using next-generation sequencing: meta-analysis"],"prefix":"10.2478","volume":"57","author":[{"given":"Jelena","family":"Kostic Peric","sequence":"first","affiliation":[{"name":"Institute for Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andja","family":"Cirkovic","sequence":"additional","affiliation":[{"name":"Department for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Srzentic Drazilov","sequence":"additional","affiliation":[{"name":"Institute for Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalija","family":"Samardzic","sequence":"additional","affiliation":[{"name":"University Hospital of Pulmonology, Clinical Centre of Serbia , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Skodric Trifunovic","sequence":"additional","affiliation":[{"name":"University Hospital of Pulmonology, Clinical Centre of Serbia , Belgrade , Serbia"},{"name":"Faculty of Medicine, University of Belgrade , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Internal Medicine Clinic \u201cAkta Medica\u201d , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Institute for Molecular Genetics and Genetic Engineering, University of Belgrade , Belgrade , Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"2026080916204971180_j_raon-2023-0013_ref_001","doi-asserted-by":"crossref","unstructured":"Cowen D, Richaud P, Mornex F, Bachelot T, Jung GM, Mirabel X, et al. 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