{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:07:42Z","timestamp":1783901262882,"version":"3.55.0"},"reference-count":35,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While computed tomography (CT)-guided liver biopsies are commonly performed using unenhanced images, contrast-enhanced images are beneficial for challenging puncture pathways and lesion locations. This study aimed to evaluate the accuracy of CT-guided biopsies for intrahepatic lesions using unenhanced, intravenous (IV)-enhanced, or intra-arterial Lipiodol-marked CT for lesion marking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      Six-hundred-seven patients (men: 358 [59.0%], mean age 61 years; SD \u00b112.04) with suspect hepatic lesions and CT-guided liver biopsies were retrospectively evaluated. Successful biopsies were histopathological findings other than typical liver tissue or non-specific findings. Data was ascertained regarding the use of contrast medium for the biopsy-planning CT, unenhanced (group 1)\n                      <jats:italic>vs.<\/jats:italic>\n                      Lipiodol (group 2)\n                      <jats:italic>vs.<\/jats:italic>\n                      IV contrast (group 3). Technical success and influencing factors were insulated. Complications were noted. The results were analyzed using the Wilcoxon-Man-Whitney t-test, Chi-square test, and Spearman-Rho.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall lesion hitting rate was 73.1%, with significantly better rates using Lipiodol-marked lesions (79.3%) compared to group 1 (73.8%) and group 3 (65.2%) (p = 0.037). Smaller lesions (&lt;20 mm diameter) benefited significantly from Lipiodol-marking with 71.2% successful biopsy rate compared to group 1 (65.5%) and group 3 (47.7%) (p = 0.021). Liver cirrhosis (p = 0.94) and entity of parenchymal lesions (p = 0.78) had no impact on the hitting rate between the groups. No major complications occurred during the interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-biopsy Lipiodol marking of suspect hepatic lesions significantly increases the lesion-hitting rate and is especially beneficial for biopsy of smaller targets below 20 mm diameter. Further, Lipiodol marking is superior to IV contrast for non-visible lesions in unenhanced CT. Target lesion entity has no impact on the hitting rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2023-0024","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T07:14:25Z","timestamp":1687331665000},"page":"158-167","source":"Crossref","is-referenced-by-count":2,"title":["CT-guided biopsies of unspecified suspect intrahepatic lesions: pre-procedure Lipiodol-marking improves the biopsy success rate"],"prefix":"10.2478","volume":"57","author":[{"given":"Marcel Christian","family":"Langenbach","sequence":"first","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"},{"name":"Cardiovascular Imaging Research Center, Department of Radiology , Massachusetts General Hospital, Harvard Medical School , Boston , MA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Joseph","family":"Vogl","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Buchinger","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Eichler","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Erik","family":"Scholtz","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Hammerstingl","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Gruber-Rouh","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology , University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"2026071211471532651_j_raon-2023-0024_ref_001","doi-asserted-by":"crossref","unstructured":"Bravo AA, Sheth SG, Chopra S. 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