{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:09:25Z","timestamp":1783901365424,"version":"3.55.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of the study was to assess the role of diffusion-weighted imaging (DWI) to evaluate treatment response in patients with liver metastases of colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>In this retrospective, observational cohort study, we included 19 patients with 18 responding metastases (R-Mets; follow-up at least one year) and 11 non-responding metastases (NR-Mets; local tumor recurrence within one year) who were treated with high-dose-rate brachytherapy (HDR-BT) and underwent pre- and post-interventional MRI. DWI (qualitatively, mean apparent diffusion coefficient [ADCmean], ADCmin, intraindividual change of ADCmean and ADCmin) were evaluated and compared between pre-interventional MRI, first follow-up after 3 months and second follow-up at the time of the local tumor recurrence (in NR-Mets, mean: 284 \u00b1 122 d) or after 12 months (in R-Mets, mean: 387+\/\u221264 d). Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) for detection of local tumor recurrence were calculated on second follow up, evaluating (1) DWI images only, and (2) DWI with Gd-enhanced T1-weighted images on hepatobiliary phase (contrast-enhanced [CE] T1-weight [T1w] hepatobiliary phase [hb])<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ADCmean significantly increased 3 months after HDR-BT in both groups (R-Mets: 1.48 \u00b1 0.44 and NR-Mets: 1.49 \u00b1 0.19 x 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      ;\/s, p &lt; 0.0001 and p = 0.01), however, intraindividual change of ADCmean (175%\n                      <jats:italic>vs<\/jats:italic>\n                      .127%, p = 0.03) and ADCmin values (0.44 \u00b1 0.24 to 0.82 \u00b1 0.58 x 10\n                      <jats:sup>\u22123<\/jats:sup>\n                      mm\n                      <jats:sup>2<\/jats:sup>\n                      \/s) significantly increased only in R-Mets (p &lt; 0.0001 and p &lt; 0.001). ADCmin was significant higher in R-Mets compared to NR-Mets on first follow-up (p = 0.04). Sensitivity (1\n                      <jats:italic>vs<\/jats:italic>\n                      . 0.72), specificity (0.94\n                      <jats:italic>vs<\/jats:italic>\n                      . 0.72), PPV (0.91\n                      <jats:italic>vs<\/jats:italic>\n                      . 0.61) and NPV (1\n                      <jats:italic>vs<\/jats:italic>\n                      . 0.81) could be improved by combining DWI with CE T1w hb compared to DWI only.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DW-MRI seems to be helpful in the qualitative and quantitative evaluation of treatment response after HDR-BT of colorectal metastases in the liver.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2478\/raon-2024-0017","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T18:47:06Z","timestamp":1708454826000},"page":"33-42","source":"Crossref","is-referenced-by-count":1,"title":["Role of diffusion-weighted imaging in response prediction and evaluation after high dose rate brachytherapy in patients with colorectal liver metastases"],"prefix":"10.2478","volume":"58","author":[{"given":"Salma","family":"Karim","sequence":"first","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricarda","family":"Seidensticker","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Seidensticker","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"},{"name":"ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEntero-Pancreatic System at the University Hospital of Munich (GEPNET KUM), University Hospital of Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Ricke","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"},{"name":"ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEntero-Pancreatic System at the University Hospital of Munich (GEPNET KUM), University Hospital of Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Schinner","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Treitl","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"R\u00fcbenthaler","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"},{"name":"ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEntero-Pancreatic System at the University Hospital of Munich (GEPNET KUM), University Hospital of Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ingenerf","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Schmid-Tannwald","sequence":"additional","affiliation":[{"name":"Department of Radiology , University Hospital , LMU Munich , Germany"},{"name":"ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumours of the GastroEntero-Pancreatic System at the University Hospital of Munich (GEPNET KUM), University Hospital of Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"2026071211371588005_j_raon-2024-0017_ref_001","doi-asserted-by":"crossref","unstructured":"Ricke J, Wust P, Stohlmann A, Beck A, Cho CH, Pech M, et al. 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