{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:16:41Z","timestamp":1783613801423,"version":"3.55.0"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma is common in eosinophilic granulomatosis with polyangiitis (EGPA), and the annual incidence of EGPA in patients with asthma is much higher compared with the general population, and the trigger factor for this is unknown. We report a case of a 19-year-old male with a background of severe asthma who presented with eosinophilic lung infiltration after viral infection, which progressed to clinical EGPA. The diagnosis of EGPA was supported by an initial clinical presentation of recurrent cough and wheezing accompanied by a red rash, followed by peripheral eosinophilia, a high eosinophil percentage in bronchoalveolar lavage fluid (BALF), and migratory pulmonary eosinophilic infiltrates. Lung biopsy showed blood vessels with extravascular eosinophils. The patient responded well to high-dose glucocorticoids and cyclophosphamide, and symptoms and biochemical markers improved. Our literature review identified few reports on the triggers of EGPA, which highlights that viral infection may be a risk factor for asthma that progresses to EGPA.<\/jats:p>","DOI":"10.2478\/rir-2021-0034","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:52:06Z","timestamp":1645458726000},"page":"249-254","source":"Crossref","is-referenced-by-count":3,"title":["Severe asthma with viral infection can develop into eosinophilic granulomatosis with polyangiitis"],"prefix":"10.2478","volume":"2","author":[{"given":"Changxing","family":"Ou","sequence":"first","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine , State Key Laboratory of Respiratory Diseases , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine , State Key Laboratory of Respiratory Diseases , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China ."},{"name":"Department of Pediatric Hematology , Affiliated Hospital of Guizhou Medical University , Guiyang , Guizhou Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lai","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine , State Key Laboratory of Respiratory Diseases , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Li","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine , State Key Laboratory of Respiratory Diseases , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Xie","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine , State Key Laboratory of Respiratory Diseases , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, The Second Affiliated Hospital , State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology , Guangzhou Medical University , Guangzhou , Guangdong Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine , State Key Laboratory of Respiratory Diseases , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong Province , China ."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"2026070916003582234_j_rir-2021-0034_ref_001","unstructured":"Churg J, Strauss L. 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