{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:34:45Z","timestamp":1784770485060,"version":"3.55.0"},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_rir-2023-0030_s_012\">\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Recently, the role of long non-coding RNA (lncRNA) in rheumatic immune diseases has attracted widespread attention. However, knowledge of lncRNA in connective tissue disease-associated interstitial lung disease (CTD-ILD) is limited. This study explored the expression profile and possible mechanisms of lncRNA and mRNA in peripheral blood mononuclear cells (PBMCs) of CTD-ILD patients, especially systemic sclerosis (SSc)-ILD and rheumatoid arthritis (RA)-ILD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_rir-2023-0030_s_013\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>LncRNA microarray analysis identified 240 diferentially expressed lncRNAs and 218 diferentially expressed mRNA in the CTD-ILD group and the connective tissue disease without associated interstitial lung disease (CTD-NILD) group. The bioinformatics analysis of diferential genes has identified several important biological processes and signal pathways, including nuclear factor kappa B (NF-kappa B) signaling pathway, interleukin 17 (IL-17) signaling pathway, B cell receptor signaling pathway. Relative expression levels of five diferentially expressed lncRNAs and one mRNA in 120 SSc and RA patients with or without ILD were detected by quantitative reverse-transcription (PCR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_rir-2023-0030_s_014\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The <jats:italic>ENST00000604692<\/jats:italic> expression level was significantly higher in the ILD than the without interstitial lung disease (NILD) group; <jats:italic>T311354<\/jats:italic> and arginase-1 were significantly higher in SSc than RA group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_rir-2023-0030_s_015\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These data suggest that the specific profile of lncRNA in PBMCs of CTD-ILD patients and the potential signal pathways related to the pathogenesis of CTD-ILD, which may provide newfound insights for the diagnosis and treatment of CTD-ILD patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.2478\/rir-2023-0030","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T10:21:13Z","timestamp":1702981273000},"page":"204-215","source":"Crossref","is-referenced-by-count":2,"title":["Identification and functional prediction of long non-coding RNA and mRNA related to connective tissue disease-associated interstitial lung diseases"],"prefix":"10.2478","volume":"4","author":[{"given":"Fei","family":"Dai","sequence":"first","affiliation":[{"name":"Research Center of Hyperuricemia and Gout, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"},{"name":"Department of Rheumatology and Immunology, the Affiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixi","family":"He","sequence":"additional","affiliation":[{"name":"Research Center of Hyperuricemia and Gout, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"},{"name":"Department of Rheumatology and Immunology, the Affiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Lei","sequence":"additional","affiliation":[{"name":"Research Center of Hyperuricemia and Gout, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"},{"name":"Department of Rheumatology and Immunology, the Affiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Research Center of Hyperuricemia and Gout, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"},{"name":"Department of Rheumatology and Immunology, the Affiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-1927","authenticated-orcid":false,"given":"Quanbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Hyperuricemia and Gout, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"},{"name":"Department of Geriatrics, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6709-7570","authenticated-orcid":false,"given":"Yufeng","family":"Qing","sequence":"additional","affiliation":[{"name":"Research Center of Hyperuricemia and Gout, the Afiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"},{"name":"Department of Rheumatology and Immunology, the Affiliated Hospital of North Sichuan Medical College , Nanchong 637000 , Sichuan Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"2023121910210657159_j_rir-2023-0030_ref_001","doi-asserted-by":"crossref","unstructured":"Mathai SC, Danoff SK. 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