{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:43:18Z","timestamp":1781271798469,"version":"3.54.1"},"reference-count":9,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tracheoesophageal fistula (TEF) is frequently congenital and requires surgical correction. TEF can also occur secondary to malignant esophageal tumors or benign diseases and these cases are managed by endoscopic means, such as closing the defect with metallic stents. Although esophageal injury can occur secondary to nonsteroidal anti-inflammatory drugs (NSAIDs), TEF secondary to chronic NSAIDs use has not been described in the literature.<\/jats:p>\n                  <jats:p>We report the case of a male patient with refractory migraine and chronic use of NSAIDs, with a history of esophageal stenosis presenting with acute-onset total dysphagia. Upper gastrointestinal endoscopy and CT-scan revealed TEF located at 25 cm from the incisors. An esophageal stent was placed endoscopically, and 6 weeks a second stent was placed in a stent-in-stent manner to allow removal of both stents. Endoscopic control after the removal of the stents showed the persistence of the fistula, so a third stent was placed as a rescue therapy.<\/jats:p>\n                  <jats:p>Against medical advice, the patient continued to use OTC painkillers and NSAIDs in large doses. Three months later, he was readmitted with total dysphagia and recent-onset dysphonia. CT scan revealed a new fistula above the already placed stent. A second metallic stent was endoscopically placed through the old stent to close the newly developed fistula. The patient was discharged on the third day with no complications and he remains well at 6 months follow-up.<\/jats:p>\n                  <jats:p>Due to small cases studies, recurrent TEF remains a therapeutic challenge. Endoscopic therapy is usually an effective solution, but complex cases might require multiple treatment sessions.<\/jats:p>","DOI":"10.2478\/rjim-2018-0014","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T18:17:01Z","timestamp":1525889821000},"page":"211-215","source":"Crossref","is-referenced-by-count":2,"title":["Endoscopic management of recurrent tracheoesophageal fistula induced by chronic use of nonsteroidal anti-inflammatory drugs: A case report and review of the literature"],"prefix":"10.2478","volume":"56","author":[{"given":"Theodor Alexandru","family":"Voiosu","sequence":"first","affiliation":[{"name":"Gastroenterology Division, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"},{"name":"UMF \u201cCarol Davila\u201d School of Medicine , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrada Viorela","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Gastroenterology Division, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Adrian","family":"Bobeica","sequence":"additional","affiliation":[{"name":"Gastroenterology Division, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei Mihai","family":"Voiosu","sequence":"additional","affiliation":[{"name":"Gastroenterology Division, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Bogdan","family":"Mateescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Division, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"},{"name":"UMF \u201cCarol Davila\u201d School of Medicine , Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"2026042915191697902_j_rjim-2018-0014_ref_001_w2aab3b7c10b1b6b1ab1ab1Aa","unstructured":"1. KE M, WU, ZENG J. The treatment strategy for tracheoesophageal fistula. J Thorac Dis. 2015; 7(Suppl 4):S389-97."},{"key":"2026042915191697902_j_rjim-2018-0014_ref_002_w2aab3b7c10b1b6b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. SHEN KR, ALLEN MS, CASSIVI SD, et al. Surgical management of acquired nonmalignant tracheoesophageal and bronchoesophageal fistulae. Ann Thorac Surg. 2010; 90(3):914-8.10.1016\/j.athoracsur.2010.05.06120732517","DOI":"10.1016\/j.athoracsur.2010.05.061"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_003_w2aab3b7c10b1b6b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. RICHTER JE, CASTELL DO. The esophagus, 5th Edition. Wiley-Blackwell, 2012.10.1002\/9781444346220","DOI":"10.1002\/9781444346220"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_004_w2aab3b7c10b1b6b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. SUGAWA C, TAKEKUMA Y, LUCAS CE, AMAMOTO H. Bleeding esophageal ulcers caused by NSAIDs. Surg Endosc.1997; 11:143-6.10.1007\/s0046499003179069146","DOI":"10.1007\/s004649900317"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_005_w2aab3b7c10b1b6b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. LANAS A, HIRSCHOWITZ BI. Significant role of aspirin use in patients with esophagitis. J Clin Gastroenterology. 1991; 13(6):622-7.10.1097\/00004836-199112000-000051761835","DOI":"10.1097\/00004836-199112000-00005"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_006_w2aab3b7c10b1b6b1ab1ab6Aa","doi-asserted-by":"crossref","unstructured":"6. LIU YH, KO PJ, WU YC, LIU HP, TSAI YH. Silicone airway stent for treating benign tracheoesophageal fistula. Asian Cardiovasc Thorac Ann. 2005; 13(2): 178-80.10.1177\/02184923050130021815905351","DOI":"10.1177\/021849230501300218"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_007_w2aab3b7c10b1b6b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. CHAWLA RK, MADAN A, CHAWLA K. Tracheo-esophageal fistula: Successful palliation after failed esophageal stent. Lung India. 2012; 29(3):289-92.10.4103\/0970-2113.99123342487422919174","DOI":"10.4103\/0970-2113.99123"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_008_w2aab3b7c10b1b6b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. CERNA M., KOCHER M., VALEK V. et al. Covered biodegradable stent: new therapeutic option for the management of esophageal perforation or anastomotic leak. Cardiovasc Intervent Radiol. 2011; 34:1267-71.10.1007\/s00270-010-0059-921213108","DOI":"10.1007\/s00270-010-0059-9"},{"key":"2026042915191697902_j_rjim-2018-0014_ref_009_w2aab3b7c10b1b6b1ab1ab9Aa","doi-asserted-by":"crossref","unstructured":"9. SIGOUNAS DE, SIDDHI S, PLEVRIS JN. Biodegradable esophageal stents in benign and malignant strictures \u2013 a single center experience. Endosc Int Open. 2016; 4(6): E618-E623.10.1055\/s-0042-105433499389527556067","DOI":"10.1055\/s-0042-105433"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/rjim.2018.56.issue-3\/rjim-2018-0014\/rjim-2018-0014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/reference-global.com\/pdf\/10.2478\/rjim-2018-0014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:38:07Z","timestamp":1777487887000},"score":1,"resource":{"primary":{"URL":"https:\/\/reference-global.com\/article\/10.2478\/rjim-2018-0014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,8,29]]},"published-print":{"date-parts":[[2018,9,1]]}},"alternative-id":["10.2478\/rjim-2018-0014"],"URL":"https:\/\/doi.org\/10.2478\/rjim-2018-0014","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]}}}